SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ued'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 7 THR A  68
PHE A  66
ARG A  42
LYS A  65
 None
 1.24A 2kotA-4uedA:
undetectable		 2kotA-4uedA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		5 / 10 GLU A 132
GLY A 180
VAL A 176
ALA A 175
PHE A 142
 None
 1.14A 3a3yA-4uedA:
undetectable		 3a3yA-4uedA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		5 / 10 GLU A 132
GLY A 180
VAL A 176
PHE A 142
THR A 167
 None
 1.08A 3a3yA-4uedA:
undetectable		 3a3yA-4uedA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 4 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.32A 3sudA-4uedA:
0.7		 3sudA-4uedA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		3 / 3 ASN A  41
TRP A  43
ASP A 147
 None
 1.27A 4a7tA-4uedA:
undetectable
4a7tF-4uedA:
undetectable		 4a7tA-4uedA:
20.77
4a7tF-4uedA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 7 LEU A  93
LYS A  95
LEU A 137
GLU A 140
 None
 1.03A 5t7bA-4uedA:
undetectable		 5t7bA-4uedA:
11.50