SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 198
ALA A 201
LEU A 174
THR A 236
ILE A 191
 None
 1.13A 1crbA-4uekA:
undetectable		 1crbA-4uekA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 5 HIS A  59
GLU A 144
ALA A  82
SER A  62
 ZN  A1347 ( 3.4A)
TRS  A1350 (-2.6A)
None
None
 1.33A 1errA-4uekA:
undetectable
1errB-4uekA:
undetectable		 1errA-4uekA:
22.53
1errB-4uekA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ALA A 152
GLY A 173
THR A 236
ILE A 166
 None
 0.68A 1gtnI-4uekA:
undetectable
1gtnJ-4uekA:
undetectable		 1gtnI-4uekA:
15.16
1gtnJ-4uekA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 5 PRO A 136
LEU A 131
THR A 301
ARG A 304
 None
 1.23A 1i2wA-4uekA:
undetectable		 1i2wA-4uekA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 6 LEU A 344
PHE A 323
TYR A 120
VAL A   4
 None
 1.24A 1ibgH-4uekA:
undetectable		 1ibgH-4uekA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 5 PRO A  43
ILE A  45
ARG A  44
ASP A  41
 None
None
TRS  A1350 ( 4.1A)
None
 1.29A 2rhmB-4uekA:
2.7		 2rhmB-4uekA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A 254
GLN A 208
THR A 189
PHE A 210
ILE A 249
 None
 1.34A 2v95A-4uekA:
undetectable		 2v95A-4uekA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 212
GLU A 235
ASP A 192
 None
 0.80A 2zthA-4uekA:
7.5		 2zthA-4uekA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 212
GLU A 235
ASP A 192
 None
 0.86A 3bwmA-4uekA:
6.6		 3bwmA-4uekA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ALA A 334
ILE A 333
ASN A 336
PRO A 339
 None
 0.98A 3fxrA-4uekA:
undetectable		 3fxrA-4uekA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 4 PRO A 240
THR A 242
GLY A 170
THR A 171
 None
 1.00A 3ib1A-4uekA:
undetectable		 3ib1A-4uekA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 7 GLN A 297
ARG A 304
GLU A 300
PRO A 132
 None
 1.23A 3ql6A-4uekA:
undetectable		 3ql6A-4uekA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 7 LEU A  86
SER A 101
GLU A 298
HIS A 151
 None
 1.23A 4aq7A-4uekA:
undetectable		 4aq7A-4uekA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 7 GLU A 196
LYS A 197
LEU A 200
LEU A 174
 None
 0.73A 4wg0B-4uekA:
undetectable
4wg0C-4uekA:
undetectable		 4wg0B-4uekA:
3.00
4wg0C-4uekA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 212
GLU A 235
ASP A 192
 None
 0.81A 4xudA-4uekA:
6.6		 4xudA-4uekA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 5 THR A  56
GLY A  58
HIS A  51
ASP A 114
 None
 1.16A 5c0oH-4uekA:
6.9		 5c0oH-4uekA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  98
PHE A  61
ILE A 121
GLY A 116
GLY A 110
 None
 1.00A 5eqbA-4uekA:
undetectable		 5eqbA-4uekA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 GLU A 144
GLY A 296
TYR A 106
PHE A 108
 TRS  A1350 (-2.6A)
None
None
None
 0.86A 5flcB-4uekA:
undetectable		 5flcB-4uekA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 GLU A 144
GLY A 296
TYR A 106
PHE A 108
 TRS  A1350 (-2.6A)
None
None
None
 0.85A 5flcF-4uekA:
undetectable		 5flcF-4uekA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ILE A 345
PHE A 326
PHE A 142
THR A 171
 None
 1.33A 5g08A-4uekA:
undetectable		 5g08A-4uekA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ALA A 206
ALA A 190
ILE A 177
LEU A 174
 None
 0.60A 5jncD-4uekA:
undetectable		 5jncD-4uekA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.10A 5n0oA-4uekA:
2.9		 5n0oA-4uekA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.11A 5n0oB-4uekA:
3.1		 5n0oB-4uekA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.10A 5n0rA-4uekA:
2.2		 5n0rA-4uekA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.11A 5n0wA-4uekA:
2.3		 5n0wA-4uekA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.14A 5n0xA-4uekA:
2.9		 5n0xA-4uekA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.15A 5n0xB-4uekA:
2.9		 5n0xB-4uekA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 7 ILE A 233
GLN A 231
VAL A 164
ALA A 180
 None
 0.98A 6cduC-4uekA:
undetectable
6cduD-4uekA:
undetectable		 6cduC-4uekA:
21.31
6cduD-4uekA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ILE A 233
GLN A 231
VAL A 164
ILE A 166
 None
 0.95A 6cduG-4uekA:
undetectable
6cduH-4uekA:
undetectable		 6cduG-4uekA:
21.31
6cduH-4uekA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE
(Escherichia
coli) 		4 / 6 TYR A 106
ASN A 289
TYR A 290
GLU A  60
 None
TRS  A1350 ( 4.5A)
None
ZN  A1347 ( 4.6A)
 1.43A 6gneA-4uekA:
3.6		 6gneA-4uekA:
21.99