SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4uer EIF3A
(Lachancea
kluyveri) 		3 / 3 ASP a 231
ARG a 235
ILE a 177
 None
 0.86A 1a4gB-4uera:
undetectable		 1a4gB-4uera:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4uer EIF3B
(Lachancea
kluyveri) 		3 / 3 TRP b 642
ARG b 688
THR b 641
 None
 0.98A 1df7A-4uerb:
undetectable		 1df7A-4uerb:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4uer EIF3B
(Lachancea
kluyveri) 		4 / 8 SER b 266
SER b 305
TYR b 271
PHE b 273
 None
 1.22A 1eqbA-4uerb:
undetectable
1eqbB-4uerb:
undetectable		 1eqbA-4uerb:
19.21
1eqbB-4uerb:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4uer EIF3B
(Lachancea
kluyveri) 		4 / 8 TYR b 271
PHE b 273
SER b 266
SER b 305
 None
 1.21A 1eqbA-4uerb:
undetectable
1eqbB-4uerb:
undetectable		 1eqbA-4uerb:
19.21
1eqbB-4uerb:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4uer EIF3B
(Lachancea
kluyveri) 		4 / 8 SER b 266
SER b 305
TYR b 271
PHE b 273
 None
 1.23A 1eqbC-4uerb:
undetectable
1eqbD-4uerb:
undetectable		 1eqbC-4uerb:
19.21
1eqbD-4uerb:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4uer EIF3B
(Lachancea
kluyveri) 		4 / 8 TYR b 271
PHE b 273
SER b 266
SER b 305
 None
 1.22A 1eqbC-4uerb:
undetectable
1eqbD-4uerb:
undetectable		 1eqbC-4uerb:
19.21
1eqbD-4uerb:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4uer EIF3B
(Lachancea
kluyveri) 		3 / 4 VAL b 529
TRP b 565
TRP b 581
 None
 1.14A 1gmkA-4uerb:
undetectable
1gmkB-4uerb:
undetectable		 1gmkA-4uerb:
2.02
1gmkB-4uerb:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4uer EIF3B
(Lachancea
kluyveri) 		3 / 4 VAL b 529
TRP b 565
TRP b 581
 None
 0.58A 1gmkC-4uerb:
undetectable
1gmkD-4uerb:
undetectable		 1gmkC-4uerb:
2.02
1gmkD-4uerb:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 7 VAL c 717
VAL c 709
ILE c 560
LEU c 703
 None
 0.82A 1iepB-4uerc:
2.4		 1iepB-4uerc:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 6 GLU c 416
LEU c 429
LEU c 486
GLY c 485
 None
 0.88A 1n13H-4uerc:
undetectable
1n13K-4uerc:
undetectable		 1n13H-4uerc:
8.26
1n13K-4uerc:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 7 LEU c 429
LEU c 486
GLY c 485
GLU c 416
 None
 0.81A 1n13G-4uerc:
undetectable
1n13J-4uerc:
undetectable		 1n13G-4uerc:
6.41
1n13J-4uerc:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 8 GLU c 657
GLN c 683
SER c 648
TYR c 647
 None
 1.25A 1nx9C-4uerc:
undetectable		 1nx9C-4uerc:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 8 GLU c 657
GLN c 683
SER c 648
TYR c 647
 None
 1.26A 1nx9D-4uerc:
undetectable		 1nx9D-4uerc:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4uer EIF3B
(Lachancea
kluyveri) 		5 / 11 LEU b 567
ILE b 531
THR b 530
THR b 574
GLN b 604
 None
 1.25A 1tw4A-4uerb:
2.0		 1tw4A-4uerb:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 4uer EIF3B
(Lachancea
kluyveri) 		5 / 10 LEU b 567
ILE b 531
THR b 530
THR b 574
GLN b 604
 None
 1.25A 1tw4B-4uerb:
0.9		 1tw4B-4uerb:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4uer EIF3B
(Lachancea
kluyveri) 		5 / 10 PHE b 408
ALA b 447
LEU b 400
ALA b 397
VAL b 385
 None
 1.16A 2bxeA-4uerb:
undetectable		 2bxeA-4uerb:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4uer EIF3C
(Lachancea
kluyveri) 		5 / 12 LEU c 713
LEU c 557
ALA c 554
LEU c 616
THR c 623
 None
 1.27A 2oaxB-4uerc:
undetectable		 2oaxB-4uerc:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 8 GLU c 416
LEU c 429
LEU c 486
GLY c 485
 None
 0.77A 2qqdB-4uerc:
undetectable
2qqdC-4uerc:
undetectable		 2qqdB-4uerc:
8.26
2qqdC-4uerc:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4uer EIF3A
(Lachancea
kluyveri) 		5 / 11 SER a 369
ILE a 370
ALA a 332
THR a 335
LEU a 297
 None
 1.18A 2v0mD-4uera:
undetectable		 2v0mD-4uera:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 8 ILE a  58
GLY a  59
LEU a  68
LEU a  72
 None
 0.88A 2vctC-4uera:
4.1		 2vctC-4uera:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4uer EIF3B
(Lachancea
kluyveri) 		4 / 6 THR b 638
VAL b 594
GLU b 661
SER b 601
 None
 1.25A 3b6rB-4uerb:
undetectable		 3b6rB-4uerb:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 5 VAL a 182
VAL a 183
THR a 158
THR a 178
 None
 1.23A 3bjwG-4uera:
undetectable		 3bjwG-4uera:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 5 VAL a 182
VAL a 183
THR a 158
THR a 178
 None
 1.23A 3bjwD-4uera:
undetectable		 3bjwD-4uera:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4uer EIF3B
(Lachancea
kluyveri) 		3 / 3 GLU b 522
SER b 623
VAL b 622
 None
 0.80A 3eeoA-4uerb:
undetectable		 3eeoA-4uerb:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4uer EIF3C
(Lachancea
kluyveri) 		3 / 3 ASP c 618
PHE c 621
SER c 573
 None
 0.95A 3i5uB-4uerc:
2.6		 3i5uB-4uerc:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4uer EIF3B
(Lachancea
kluyveri) 		5 / 12 TYR b 664
GLY b 663
SER b 655
ASP b 677
ILE b 678
 None
 1.02A 3id6C-4uerb:
undetectable		 3id6C-4uerb:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4uer EIF3A
(Lachancea
kluyveri) 		5 / 11 ILE a 465
LEU a 448
LEU a 451
THR a 453
ALA a 452
 None
 1.11A 3kw2B-4uera:
undetectable		 3kw2B-4uera:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4uer EIF3C
(Lachancea
kluyveri) 		3 / 3 LYS c 382
ARG c 603
ASP c 305
 None
 1.04A 3o7wA-4uerc:
undetectable		 3o7wA-4uerc:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4uer EIF3C
(Lachancea
kluyveri) 		3 / 3 PHE c 304
SER c 307
GLN c 313
 None
 1.00A 3smtA-4uerc:
undetectable		 3smtA-4uerc:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_SAMA1000_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4uer EIF3B
(Lachancea
kluyveri) 		5 / 10 GLU b 535
PHE b 492
THR b 530
ARG b 549
PHE b 517
 None
 1.38A 3smtA-4uerb:
0.0		 3smtA-4uerb:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 5 HIS a 484
THR a 481
GLU a 466
ASP a 464
 None
 1.42A 3tm4A-4uera:
undetectable		 3tm4A-4uera:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 5 HIS a 484
THR a 481
GLU a 466
ASP a 464
 None
 1.44A 3tm4B-4uera:
undetectable		 3tm4B-4uera:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 8 TYR c 442
HIS c 611
TYR c 394
LEU c 385
 None
 1.38A 3uzzB-4uerc:
undetectable		 3uzzB-4uerc:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4uer EIF3C
(Lachancea
kluyveri) 		5 / 12 GLN c 412
LEU c 482
LEU c 486
GLU c 452
SER c 469
 None
 1.37A 4aqlA-4uerc:
undetectable		 4aqlA-4uerc:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4uer EIF3C
(Lachancea
kluyveri) 		3 / 3 ARG c 436
THR c 453
TRP c 456
 None
 0.95A 4d7hA-4uerc:
2.7		 4d7hA-4uerc:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4uer EIF3A
(Lachancea
kluyveri) 		5 / 12 MET a 187
PHE a 199
ASN a 281
SER a 259
ARG a 207
 None
 1.37A 4djeB-4uera:
undetectable		 4djeB-4uera:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 7 GLN c 757
PHE c 776
ASN c 770
ASP c 771
 None
 1.43A 4kcnB-4uerc:
undetectable		 4kcnB-4uerc:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4uer EIF3C
(Lachancea
kluyveri) 		3 / 3 LEU c 258
ILE c 262
ARG c 265
 None
 0.67A 4mk4B-4uerc:
undetectable		 4mk4B-4uerc:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 8 LEU a 286
LYS a 288
VAL a 248
TYR a 257
 None
 1.07A 4q0bA-4uera:
undetectable		 4q0bA-4uera:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 8 PRO a 457
PHE a 417
LEU a 424
LEU a 408
 None
 0.66A 4qopC-4uera:
undetectable		 4qopC-4uera:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4uer EIF3C
(Lachancea
kluyveri) 		3 / 3 ARG c 436
THR c 453
TRP c 456
 None
 0.97A 4uglA-4uerc:
2.8		 4uglA-4uerc:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4uer EIF3B
(Lachancea
kluyveri) 		5 / 11 LEU b 603
ALA b 651
VAL b 649
LYS b 665
ILE b 640
 None
 0.92A 4x20D-4uerb:
undetectable		 4x20D-4uerb:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 8 GLU a 198
ARG a 156
HIS a 209
LEU a 206
 None
 1.26A 5dxeA-4uera:
undetectable		 5dxeA-4uera:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4uer EIF3C
(Lachancea
kluyveri) 		3 / 3 ARG c 436
THR c 453
TRP c 456
 None
 0.99A 5g6cA-4uerc:
3.0		 5g6cA-4uerc:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4uer EIF3B
(Lachancea
kluyveri) 		5 / 12 THR b 530
PHE b 528
ILE b 497
PHE b 519
ASN b 480
 None
 1.35A 5hgcA-4uerb:
undetectable		 5hgcA-4uerb:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4uer EIF3A
(Lachancea
kluyveri) 		5 / 12 ASP a 338
GLU a 339
LEU a 330
LEU a 424
LEU a 387
 None
 1.19A 5hnwB-4uera:
undetectable		 5hnwB-4uera:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4uer EIF3A
(Lachancea
kluyveri) 		5 / 12 ASP a 338
GLU a 339
LEU a 330
LEU a 424
LEU a 387
 None
 1.19A 5hnyB-4uera:
undetectable		 5hnyB-4uera:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 6 VAL c 498
LYS c 500
ALA c 502
VAL c 434
 None
 1.07A 5i8fA-4uerc:
undetectable		 5i8fA-4uerc:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4uer EIF3C
(Lachancea
kluyveri) 		4 / 5 VAL c 675
LEU c 627
CYH c 624
ASP c 618
 None
 1.37A 5vcvA-4uerc:
2.9		 5vcvA-4uerc:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_C_9F2C302_1
(BETA-LACTAMASE)		 4uer EIF3C
(Lachancea
kluyveri) 		5 / 10 ARG c 436
ILE c 459
TYR c 414
THR c 418
ASP c 471
 None
 1.44A 6b5yC-4uerc:
undetectable
6b5yD-4uerc:
undetectable		 6b5yC-4uerc:
6.90
6b5yD-4uerc:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4uer EIF3A
(Lachancea
kluyveri) 		4 / 8 GLU a 198
ARG a 156
HIS a 209
LEU a 206
 None
 1.27A 6cbzA-4uera:
undetectable		 6cbzA-4uera:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4uer EIF1A
(Lachancea
kluyveri) 		4 / 5 GLY 0  54
ASN 0  55
ASP 0  53
ARG 0  57
 None
 1.37A 6dwdB-4uer0:
undetectable
6dwdD-4uer0:
undetectable		 6dwdB-4uer0:
11.43
6dwdD-4uer0:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4uer EIF3B
(Lachancea
kluyveri) 		3 / 3 TRP b 521
GLU b 522
GLU b 475
 None
 1.01A 6fhwA-4uerb:
undetectable		 6fhwA-4uerb:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4uer EIF3A
EIF3C
(Lachancea
kluyveri;
Lachancea
kluyveri) 		4 / 8 TRP a 154
ASP c 388
ARG a 156
GLU a 198
 None
 1.22A 6mn4A-4uera:
undetectable		 6mn4A-4uera:
14.18