SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ueu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		3 / 3 TRP A 171
VAL A 188
TRP A 189
 None
 1.16A 1gmkC-4ueuA:
undetectable
1gmkD-4ueuA:
undetectable		 1gmkC-4ueuA:
9.09
1gmkD-4ueuA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 LEU A 237
GLY A 192
ALA A 110
LEU A 107
PHE A 199
 None
 1.17A 1gs4A-4ueuA:
undetectable		 1gs4A-4ueuA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.15A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
MET A  56
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 1.05A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
MET A  56
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.14A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.14A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
MET A  56
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.96A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
MET A  56
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.11A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LYS A  37
VAL A  65
ILE A  79
ARG A 128
 None
 0.85A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 VAL A  65
ILE A  79
MET A  84
ARG A 128
 None
 0.58A 1iepA-4ueuA:
32.8		 1iepA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 7 VAL A  65
ILE A  79
MET A  84
LEU A 136
 None
None
None
ACP  A1264 ( 4.8A)
 0.62A 1iepB-4ueuA:
32.9		 1iepB-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 8 LEU A  93
VAL A 137
CYH A 135
GLY A  87
 None
None
None
ACP  A1264 (-3.5A)
 1.02A 1jlfA-4ueuA:
undetectable
1jlfB-4ueuA:
undetectable		 1jlfA-4ueuA:
20.26
1jlfB-4ueuA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
THR A  81
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.52A 1m17A-4ueuA:
32.4		 1m17A-4ueuA:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
GLY A  15
VAL A  22
ALA A  35
LEU A 136
TYR A  83
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.8A)
ACP  A1264 ( 4.5A)
 1.18A 1muoA-4ueuA:
12.1		 1muoA-4ueuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
GLY A  15
VAL A  22
ALA A  35
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.93A 1muoA-4ueuA:
12.1		 1muoA-4ueuA:
28.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 LEU A  14
VAL A  22
VAL A  65
THR A  81
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
 0.69A 1opjA-4ueuA:
32.3		 1opjA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
VAL A  65
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 0.67A 1opjA-4ueuA:
32.3		 1opjA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
VAL A  65
THR A  81
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
 0.62A 1opjA-4ueuA:
32.3		 1opjA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
None
 1.03A 1opjB-4ueuA:
32.3		 1opjB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
MET A  56
VAL A  65
THR A  81
GLY A  87
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.99A 1opjB-4ueuA:
32.3		 1opjB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  14
ILE A  79
MET A  84
ARG A 128
 ACP  A1264 ( 4.5A)
None
None
None
 0.62A 1opjB-4ueuA:
32.2		 1opjB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  14
LYS A  37
ILE A  79
ARG A 128
 ACP  A1264 ( 4.5A)
None
None
None
 0.90A 1opjB-4ueuA:
32.2		 1opjB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.86A 1t46A-4ueuA:
31.5		 1t46A-4ueuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
THR A  81
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
 0.79A 1t46A-4ueuA:
31.5		 1t46A-4ueuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
LYS A  37
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 0.83A 1uwhB-4ueuA:
28.4		 1uwhB-4ueuA:
36.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 0.85A 1uwjA-4ueuA:
11.4		 1uwjA-4ueuA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 0.85A 1uwjB-4ueuA:
11.5		 1uwjB-4ueuA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 9 LEU A  14
VAL A  22
ALA A  35
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.35A 1xbbA-4ueuA:
34.3		 1xbbA-4ueuA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
THR A  81
GLY A  87
LEU A  90
ASP A  91
ARG A  94
LEU A 136
 ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
None
ACP  A1264 ( 4.8A)
 0.72A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
THR A  81
LEU A  90
ARG A  94
LEU A 136
PHE A 148
 ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
None
None
ACP  A1264 ( 4.8A)
None
 0.97A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 GLY A  87
LEU A  90
ASP A  91
ARG A  94
LEU A 136
ASP A 147
 ACP  A1264 (-3.5A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.76A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.49A 2gqgA-4ueuA:
35.8		 2gqgA-4ueuA:
65.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.64A 2gqgB-4ueuA:
35.9		 2gqgB-4ueuA:
65.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.50A 2gqgB-4ueuA:
35.9		 2gqgB-4ueuA:
65.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  14
LYS A  37
VAL A  65
ILE A  79
 ACP  A1264 ( 4.5A)
None
None
None
 0.80A 2hyyB-4ueuA:
33.0		 2hyyB-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  14
VAL A  65
ILE A  79
MET A  84
 ACP  A1264 ( 4.5A)
None
None
None
 0.68A 2hyyB-4ueuA:
33.0		 2hyyB-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
ILE A  55
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 1.23A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
ILE A  55
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.18A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
VAL A  65
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.58A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.76A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
ILE A  79
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 0.94A 2hyyD-4ueuA:
32.6		 2hyyD-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.08A 2hyyD-4ueuA:
32.6		 2hyyD-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
ILE A  55
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.11A 2hyyD-4ueuA:
32.6		 2hyyD-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.78A 2itoA-4ueuA:
32.3		 2itoA-4ueuA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.74A 2itoA-4ueuA:
32.3		 2itoA-4ueuA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
GLY A  15
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.69A 2ityA-4ueuA:
32.4		 2ityA-4ueuA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
GLY A  15
VAL A  22
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.59A 2ityA-4ueuA:
32.4		 2ityA-4ueuA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
GLY A  15
VAL A  22
LYS A  37
GLU A  52
MET A  56
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.71A 2ityA-4ueuA:
32.4		 2ityA-4ueuA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.84A 2itzA-4ueuA:
32.0		 2itzA-4ueuA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
GLY A  15
VAL A  22
LYS A  37
GLU A  52
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.56A 2ivuA-4ueuA:
34.0		 2ivuA-4ueuA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.87A 2oiqA-4ueuA:
34.2		 2oiqA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
 0.67A 2oiqA-4ueuA:
34.2		 2oiqA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
MET A  56
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.76A 2oiqA-4ueuA:
34.2		 2oiqA-4ueuA:
62.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 LEU A 237
GLY A 192
ALA A 110
LEU A 107
PHE A 199
 None
 1.15A 2oz7A-4ueuA:
undetectable		 2oz7A-4ueuA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
TYR A  83
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
None
 0.93A 2pl0A-4ueuA:
33.3		 2pl0A-4ueuA:
55.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
TYR A  83
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
None
 0.76A 2pl0A-4ueuA:
33.3		 2pl0A-4ueuA:
55.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
TYR A  83
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
 0.92A 2pl0A-4ueuA:
33.3		 2pl0A-4ueuA:
55.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
TYR A  83
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
 0.79A 2pl0A-4ueuA:
33.3		 2pl0A-4ueuA:
55.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
MET A  56
VAL A  65
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.05A 2pl0A-4ueuA:
33.3		 2pl0A-4ueuA:
55.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
VAL A  65
ILE A  79
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.87A 2pl0A-4ueuA:
33.3		 2pl0A-4ueuA:
55.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 GLY A  15
VAL A  22
ALA A  35
TYR A  83
MET A  84
GLY A  87
ALA A 146
 ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
None
 0.64A 2wgjA-4ueuA:
31.1		 2wgjA-4ueuA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
TYR A  83
MET A  84
GLY A  87
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
None
None
 0.65A 2wgjA-4ueuA:
31.1		 2wgjA-4ueuA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 9 LEU A  14
VAL A  22
ALA A  35
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.44A 2xp2A-4ueuA:
32.7		 2xp2A-4ueuA:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.54A 2y6oA-4ueuA:
33.7		 2y6oA-4ueuA:
45.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.74A 2y6oA-4ueuA:
33.7		 2y6oA-4ueuA:
45.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 VAL A  22
ALA A  35
MET A  84
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.54A 2y7jC-4ueuA:
27.0		 2y7jC-4ueuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 VAL A  22
ALA A  35
MET A  84
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.55A 2y7jD-4ueuA:
27.2		 2y7jD-4ueuA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		12 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
MET A  84
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.48A 2zvaA-4ueuA:
37.8		 2zvaA-4ueuA:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 10 ARG A  12
LEU A  14
ALA A  35
LYS A  37
VAL A  65
MET A  84
GLY A  87
LEU A 136
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.65A 3aoxA-4ueuA:
31.3		 3aoxA-4ueuA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
GLY A  15
GLU A  24
ALA A  35
LYS A  37
VAL A  65
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
None
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.89A 3c7qA-4ueuA:
30.0		 3c7qA-4ueuA:
39.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 LEU A  14
VAL A  22
LYS A  37
VAL A  65
ILE A  79
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.70A 3cs9A-4ueuA:
32.6		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 LEU A  14
VAL A  22
VAL A  65
ILE A  79
VAL A 145
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.67A 3cs9A-4ueuA:
32.6		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
ILE A  55
THR A  81
GLY A  87
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 1.45A 3cs9A-4ueuA:
32.8		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
LEU A  64
THR A  81
GLY A  87
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.45A 3cs9A-4ueuA:
32.8		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
MET A  56
LEU A  64
THR A  81
HIS A 127
LEU A 136
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
 0.81A 3cs9A-4ueuA:
32.8		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
ILE A  55
THR A  81
GLY A  87
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
 1.45A 3cs9B-4ueuA:
32.8		 3cs9B-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
LEU A  64
THR A  81
GLY A  87
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
 0.42A 3cs9B-4ueuA:
32.8		 3cs9B-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
VAL A  22
LYS A  37
VAL A  65
ILE A  79
PHE A 125
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.69A 3cs9B-4ueuA:
32.8		 3cs9B-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 9 LEU A  14
VAL A  22
VAL A  65
ILE A  79
PHE A 125
LEU A 136
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.71A 3cs9B-4ueuA:
32.8		 3cs9B-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
GLU A  52
MET A  56
LEU A  64
THR A  81
HIS A 127
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
None
 1.22A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
MET A  56
LEU A  64
THR A  81
HIS A 127
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
None
 1.09A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
VAL A  22
LYS A  37
VAL A  65
ILE A  79
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.72A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
VAL A  22
VAL A  65
ILE A  79
MET A  84
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.66A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
LEU A  64
THR A  81
GLY A  87
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
 0.32A 3cs9D-4ueuA:
31.7		 3cs9D-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  14
VAL A  22
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 ( 4.8A)
None
 0.83A 3cs9D-4ueuA:
31.7		 3cs9D-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 11 LEU A  14
VAL A  22
ALA A  35
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.73A 3g0eA-4ueuA:
29.7		 3g0eA-4ueuA:
35.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 11 VAL A  22
ALA A  35
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.75A 3g0eA-4ueuA:
29.7		 3g0eA-4ueuA:
35.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 11 LEU A  14
VAL A  22
ALA A  35
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.76A 3g0fA-4ueuA:
30.7		 3g0fA-4ueuA:
35.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 10 LEU A  14
VAL A  22
ALA A  35
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.67A 3g0fB-4ueuA:
31.0		 3g0fB-4ueuA:
35.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.66A 3g5dA-4ueuA:
35.3		 3g5dA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.53A 3g5dA-4ueuA:
35.3		 3g5dA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.65A 3g5dB-4ueuA:
35.5		 3g5dB-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.56A 3g5dB-4ueuA:
35.5		 3g5dB-4ueuA:
62.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
GLU A  52
THR A  81
HIS A 127
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 1.15A 3gp0A-4ueuA:
21.8		 3gp0A-4ueuA:
27.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.02A 3gvuA-4ueuA:
32.9		 3gvuA-4ueuA:
62.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
LEU A  64
VAL A  65
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.48A 3ik3A-4ueuA:
32.2		 3ik3A-4ueuA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
LEU A  64
VAL A  65
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.52A 3ik3B-4ueuA:
31.9		 3ik3B-4ueuA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.55A 3k54A-4ueuA:
32.8		 3k54A-4ueuA:
47.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.53A 3k54A-4ueuA:
32.8		 3k54A-4ueuA:
47.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.09A 3k5vA-4ueuA:
22.5		 3k5vA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  14
LYS A  37
VAL A  65
ILE A  79
 ACP  A1264 ( 4.5A)
None
None
None
 0.71A 3k5vA-4ueuA:
22.5		 3k5vA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  14
VAL A  65
ILE A  79
MET A  84
 ACP  A1264 ( 4.5A)
None
None
None
 0.65A 3k5vA-4ueuA:
22.5		 3k5vA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.11A 3k5vB-4ueuA:
32.2		 3k5vB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 11 ALA A  35
LYS A  37
VAL A  65
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.61A 3miyA-4ueuA:
33.1		 3miyA-4ueuA:
48.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 9 ALA A  35
LYS A  37
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.58A 3miyB-4ueuA:
33.1		 3miyB-4ueuA:
48.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.09A 3ms9A-4ueuA:
32.3		 3ms9A-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LYS A  37
VAL A  65
ILE A  79
ARG A 128
 None
 1.12A 3ms9A-4ueuA:
32.3		 3ms9A-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 VAL A  65
ILE A  79
MET A  84
ARG A 128
 None
 0.94A 3ms9A-4ueuA:
32.3		 3ms9A-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.11A 3ms9B-4ueuA:
32.3		 3ms9B-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
 1.09A 3mssA-4ueuA:
32.5		 3mssA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LYS A  37
VAL A  65
ILE A  79
ARG A 128
 None
 1.09A 3mssA-4ueuA:
32.6		 3mssA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 VAL A  65
ILE A  79
MET A  84
ARG A 128
 None
 0.94A 3mssA-4ueuA:
32.6		 3mssA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 7 LYS A  37
VAL A  65
ILE A  79
ARG A 128
 None
 0.76A 3mssB-4ueuA:
32.5		 3mssB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 7 VAL A  65
ILE A  79
MET A  84
ARG A 128
 None
 0.58A 3mssB-4ueuA:
32.5		 3mssB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
 1.11A 3mssC-4ueuA:
32.4		 3mssC-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LYS A  37
VAL A  65
ILE A  79
ARG A 128
 None
 1.13A 3mssC-4ueuA:
32.4		 3mssC-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 VAL A  65
ILE A  79
MET A  84
ARG A 128
 None
 0.98A 3mssC-4ueuA:
32.4		 3mssC-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.16A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 VAL A  22
LYS A  37
VAL A  65
ILE A  79
 ACP  A1264 (-4.7A)
None
None
None
 0.67A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 VAL A  22
VAL A  65
ILE A  79
MET A  84
 ACP  A1264 (-4.7A)
None
None
None
 0.66A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.86A 3octA-4ueuA:
32.4		 3octA-4ueuA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.52A 3octA-4ueuA:
32.4		 3octA-4ueuA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
MET A  56
VAL A  65
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.91A 3oezA-4ueuA:
34.0		 3oezA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
TYR A  83
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
 0.70A 3oezA-4ueuA:
34.0		 3oezA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
MET A  56
VAL A  65
THR A  81
TYR A  83
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
 0.73A 3oezA-4ueuA:
34.0		 3oezA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.54A 3oezA-4ueuA:
34.0		 3oezA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.82A 3oezB-4ueuA:
34.0		 3oezB-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
LYS A  37
MET A  56
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.99A 3oezB-4ueuA:
34.0		 3oezB-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 VAL A  22
ALA A  35
LYS A  37
THR A  81
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
 0.71A 3og7A-4ueuA:
27.9		 3og7A-4ueuA:
35.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 GLY A  15
VAL A  22
ALA A  35
LYS A  37
THR A  81
LEU A 136
 ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
 1.02A 3ohtA-4ueuA:
17.2		 3ohtA-4ueuA:
23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 ALA A  35
GLU A  52
LEU A  64
VAL A  65
THR A  81
GLY A  87
HIS A 127
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
None
 0.92A 3oxzA-4ueuA:
32.2		 3oxzA-4ueuA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 ALA A  35
GLU A  52
MET A  56
LEU A  64
THR A  81
GLY A  87
HIS A 127
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
None
 1.05A 3oxzA-4ueuA:
32.2		 3oxzA-4ueuA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
ILE A  79
MET A  84
ARG A 128
LEU A 136
VAL A 145
 ACP  A1264 ( 4.5A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.86A 3oxzA-4ueuA:
32.2		 3oxzA-4ueuA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
LYS A  37
ILE A  79
ARG A 128
LEU A 136
VAL A 145
 ACP  A1264 ( 4.5A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.99A 3oxzA-4ueuA:
32.2		 3oxzA-4ueuA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
THR A  81
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
 1.08A 3pyyA-4ueuA:
32.8		 3pyyA-4ueuA:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.05A 3pyyB-4ueuA:
32.1		 3pyyB-4ueuA:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		12 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.69A 3qlgA-4ueuA:
34.9		 3qlgA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.63A 3qlgB-4ueuA:
35.4		 3qlgB-4ueuA:
62.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
TYR A  83
LEU A 120
HIS A 127
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
None
None
None
 1.03A 3rgfA-4ueuA:
21.5		 3rgfA-4ueuA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
MET A  56
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.53A 3sxrA-4ueuA:
33.7		 3sxrA-4ueuA:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
MET A  56
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.57A 3sxrB-4ueuA:
33.3		 3sxrB-4ueuA:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
ALA A  35
LYS A  37
VAL A  65
ILE A  79
THR A  81
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.49A 3ue4A-4ueuA:
34.8		 3ue4A-4ueuA:
64.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
MET A  56
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.66A 3ue4B-4ueuA:
34.9		 3ue4B-4ueuA:
64.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.33A 3ue4B-4ueuA:
34.9		 3ue4B-4ueuA:
64.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.63A 3ug2A-4ueuA:
31.9		 3ug2A-4ueuA:
35.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 8 TYR A 222
TRP A 242
ARG A 226
MET A 238
 None
 1.27A 3wipB-4ueuA:
undetectable
3wipC-4ueuA:
undetectable		 3wipB-4ueuA:
21.40
3wipC-4ueuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 8 TYR A 222
TRP A 242
ARG A 226
MET A 238
 None
 1.32A 3wipC-4ueuA:
undetectable
3wipD-4ueuA:
undetectable		 3wipC-4ueuA:
21.40
3wipD-4ueuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 8 TRP A 242
ARG A 226
MET A 238
TYR A 222
 None
 1.28A 3wipA-4ueuA:
undetectable
3wipE-4ueuA:
undetectable		 3wipA-4ueuA:
21.40
3wipE-4ueuA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 5 LYS A  37
ILE A  55
VAL A  65
ASP A 147
 None
 1.18A 3wzdA-4ueuA:
30.8		 3wzdA-4ueuA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 5 LYS A  37
ILE A  55
VAL A  65
LEU A 136
 None
None
None
ACP  A1264 ( 4.8A)
 0.79A 3wzdA-4ueuA:
30.8		 3wzdA-4ueuA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 LEU A  14
ALA A  35
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.51A 3zbfA-4ueuA:
33.3		 3zbfA-4ueuA:
41.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.96A 3zosA-4ueuA:
30.1		 3zosA-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
LYS A  37
GLU A  52
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.94A 3zosB-4ueuA:
30.1		 3zosB-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.88A 4ag8A-4ueuA:
31.2		 4ag8A-4ueuA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 11 LEU A  14
ALA A  35
LYS A  37
VAL A  65
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.77A 4agdA-4ueuA:
30.2		 4agdA-4ueuA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 9 LEU A  14
VAL A  22
ALA A  35
MET A  84
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 0.48A 4anqA-4ueuA:
32.3		 4anqA-4ueuA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 9 LEU A  14
VAL A  22
ALA A  35
MET A  84
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 0.48A 4ansA-4ueuA:
32.2		 4ansA-4ueuA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
GLU A  52
ILE A  55
MET A  56
THR A  81
TYR A  83
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
 1.01A 4bkjA-4ueuA:
29.8		 4bkjA-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
ILE A  55
MET A  56
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.07A 4bkjA-4ueuA:
29.8		 4bkjA-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 4 LYS A  37
LEU A  59
MET A  84
ARG A 128
 None
 1.20A 4bkjA-4ueuA:
29.8		 4bkjA-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
ILE A  55
MET A  56
THR A  81
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
 1.11A 4bkjB-4ueuA:
29.8		 4bkjB-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
ILE A  55
MET A  56
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.11A 4bkjB-4ueuA:
29.8		 4bkjB-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 5 LYS A  37
LEU A  59
TYR A  83
MET A  84
ARG A 128
 None
None
ACP  A1264 ( 4.5A)
None
None
 1.28A 4bkjB-4ueuA:
29.8		 4bkjB-4ueuA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.85A 4c8bA-4ueuA:
27.2		 4c8bA-4ueuA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
LYS A  37
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.75A 4c8bB-4ueuA:
27.0		 4c8bB-4ueuA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 VAL A  22
ALA A  35
GLU A  52
ILE A  55
MET A  56
VAL A  65
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.89A 4csvA-4ueuA:
35.8		 4csvA-4ueuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
THR A  81
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.64A 4hjoA-4ueuA:
29.7		 4hjoA-4ueuA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
GLY A  15
VAL A  22
ALA A  35
LYS A  37
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.71A 4i22A-4ueuA:
28.5		 4i22A-4ueuA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
GLY A  87
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.66A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
 0.57A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
GLY A  87
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.65A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
GLY A  87
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
 0.53A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.63A 4mxoB-4ueuA:
36.8		 4mxoB-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.58A 4mxoB-4ueuA:
36.8		 4mxoB-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.68A 4mxoB-4ueuA:
36.8		 4mxoB-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.60A 4mxoB-4ueuA:
36.8		 4mxoB-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.66A 4mxxA-4ueuA:
36.4		 4mxxA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
VAL A  65
THR A  81
TYR A  83
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.56A 4mxxB-4ueuA:
34.1		 4mxxB-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
TYR A  83
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.67A 4mxyA-4ueuA:
36.1		 4mxyA-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
LYS A  37
GLU A  52
ILE A  79
TYR A  83
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.77A 4mxyA-4ueuA:
36.1		 4mxyA-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
TYR A  83
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 0.67A 4mxyB-4ueuA:
36.8		 4mxyB-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
TYR A  83
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 0.59A 4mxyB-4ueuA:
36.8		 4mxyB-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
TYR A  83
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.67A 4mxzA-4ueuA:
36.1		 4mxzA-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
LYS A  37
GLU A  52
ILE A  79
TYR A  83
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.77A 4mxzA-4ueuA:
36.1		 4mxzA-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
TYR A  83
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 0.67A 4mxzB-4ueuA:
36.8		 4mxzB-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
TYR A  83
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 0.59A 4mxzB-4ueuA:
36.8		 4mxzB-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
LYS A  37
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.67A 4otwA-4ueuA:
28.5		 4otwA-4ueuA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 0.92A 4otwA-4ueuA:
28.5		 4otwA-4ueuA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
LYS A  37
GLU A  52
ILE A  79
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.91A 4qmnA-4ueuA:
28.7		 4qmnA-4ueuA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 11 ALA A  35
LYS A  37
ILE A  79
TYR A  83
LEU A 136
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
 0.67A 4qmsA-4ueuA:
28.4		 4qmsA-4ueuA:
28.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 ALA A  35
GLU A  52
MET A  56
LEU A 120
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
None
 1.02A 4qrcA-4ueuA:
30.9		 4qrcA-4ueuA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
LEU A 136
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
 0.89A 4r7iA-4ueuA:
31.4		 4r7iA-4ueuA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 5 LEU A  14
VAL A  65
TYR A  83
ARG A 128
 ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.5A)
None
 1.02A 4r7iA-4ueuA:
31.4		 4r7iA-4ueuA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 ALA A  35
LYS A  37
ILE A  79
THR A  81
SER A  88
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-4.3A)
 0.58A 4rzvA-4ueuA:
11.4		 4rzvA-4ueuA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 ALA A  35
LYS A  37
THR A  81
SER A  88
PHE A 148
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-4.3A)
None
 0.92A 4rzvA-4ueuA:
11.4		 4rzvA-4ueuA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
LYS A  37
THR A  81
SER A  88
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-4.3A)
None
 1.02A 4rzvB-4ueuA:
26.5		 4rzvB-4ueuA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.57A 4twpA-4ueuA:
34.5		 4twpA-4ueuA:
66.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.70A 4twpA-4ueuA:
34.5		 4twpA-4ueuA:
66.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.65A 4twpA-4ueuA:
34.5		 4twpA-4ueuA:
66.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.62A 4twpB-4ueuA:
35.1		 4twpB-4ueuA:
66.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.74A 4twpB-4ueuA:
35.1		 4twpB-4ueuA:
66.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
GLU A  52
MET A  56
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
None
 1.04A 4tyjA-4ueuA:
31.4		 4tyjA-4ueuA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 LEU A  14
VAL A  22
GLU A  52
LEU A  59
VAL A  65
TYR A  83
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 ( 4.5A)
 0.83A 4u0iA-4ueuA:
31.4		 4u0iA-4ueuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 LEU A  14
VAL A  22
GLU A  52
VAL A  65
TYR A  83
ARG A 128
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
None
 0.86A 4u0iA-4ueuA:
31.4		 4u0iA-4ueuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
LYS A  37
THR A  81
GLY A  87
HIS A 127
LEU A 136
ASP A 147
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.78A 4u0iA-4ueuA:
31.4		 4u0iA-4ueuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 11 LEU A  14
VAL A  22
ALA A  35
TYR A  83
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.53A 4u5jA-4ueuA:
36.6		 4u5jA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 9 LEU A  14
VAL A  22
ALA A  35
TYR A  83
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.50A 4u5jB-4ueuA:
35.5		 4u5jB-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 ALA A  35
LEU A 120
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.8A)
None
 0.57A 4uxqA-4ueuA:
31.2		 4uxqA-4ueuA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
GLU A  52
MET A  56
LEU A 120
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
None
None
 1.07A 4v01A-4ueuA:
30.1		 4v01A-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
VAL A  22
LYS A  37
TYR A  83
ARG A 128
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
 0.96A 4v01A-4ueuA:
30.1		 4v01A-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
GLU A  52
MET A  56
HIS A 127
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
None
None
 1.06A 4v01B-4ueuA:
30.8		 4v01B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
GLU A  52
MET A  56
LEU A 120
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
None
None
 0.94A 4v01B-4ueuA:
30.8		 4v01B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
VAL A  22
LYS A  37
ILE A  55
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 1.09A 4v01B-4ueuA:
30.8		 4v01B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 9 LEU A  14
VAL A  22
LYS A  37
TYR A  83
ARG A 128
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
 0.59A 4v01B-4ueuA:
30.8		 4v01B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
GLU A  52
HIS A 127
ALA A 146
ASP A 147
GLY A 149
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
None
 1.36A 4v04A-4ueuA:
30.3		 4v04A-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 8 LYS A  37
MET A  56
TYR A  83
LEU A 136
 None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.73A 4v04A-4ueuA:
30.3		 4v04A-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 LEU A  14
VAL A  22
LYS A  37
MET A  56
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.88A 4v04B-4ueuA:
30.7		 4v04B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 LEU A  14
VAL A  22
LYS A  37
TYR A  83
ARG A 128
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
 1.06A 4v04B-4ueuA:
30.7		 4v04B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
GLU A  52
HIS A 127
ALA A 146
ASP A 147
GLY A 149
 ACP  A1264 (-2.9A)
None
None
None
None
None
 1.38A 4v04B-4ueuA:
30.7		 4v04B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 11 LEU A  14
ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.99A 4wa9A-4ueuA:
29.9		 4wa9A-4ueuA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 11 LEU A  14
ALA A  35
THR A  81
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.48A 4wa9A-4ueuA:
29.9		 4wa9A-4ueuA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
LYS A  37
THR A  81
MET A  84
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
 0.82A 4wa9B-4ueuA:
33.7		 4wa9B-4ueuA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
THR A  81
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.65A 4wa9B-4ueuA:
33.7		 4wa9B-4ueuA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 6 ARG A  12
LEU A  14
ALA A  35
MET A  84
LEU A 136
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.8A)
 0.93A 4wboC-4ueuA:
23.6		 4wboC-4ueuA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.72A 4wkqA-4ueuA:
32.1		 4wkqA-4ueuA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.72A 4wkqA-4ueuA:
32.1		 4wkqA-4ueuA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.76A 4xeyA-4ueuA:
34.4		 4xeyA-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.57A 4xeyA-4ueuA:
34.4		 4xeyA-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
ILE A  79
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.53A 4xeyB-4ueuA:
33.6		 4xeyB-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.74A 4xeyB-4ueuA:
33.6		 4xeyB-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
ALA A  35
LYS A  37
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.45A 4xeyB-4ueuA:
33.6		 4xeyB-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
ILE A  79
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.49A 4xeyB-4ueuA:
33.6		 4xeyB-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
MET A  56
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.75A 4xeyB-4ueuA:
33.6		 4xeyB-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.35A 4xeyB-4ueuA:
33.6		 4xeyB-4ueuA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		11 / 12 LEU A  14
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
TYR A  83
MET A  84
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.61A 4xliA-4ueuA:
36.1		 4xliA-4ueuA:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
TYR A  83
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.68A 4xliA-4ueuA:
36.1		 4xliA-4ueuA:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		12 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.54A 4xliB-4ueuA:
36.2		 4xliB-4ueuA:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 9 LEU A  14
VAL A  22
ALA A  35
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.43A 5aaaA-4ueuA:
32.5		 5aaaA-4ueuA:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 10 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.56A 5aabA-4ueuA:
32.5		 5aabA-4ueuA:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 10 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.63A 5aacA-4ueuA:
32.2		 5aacA-4ueuA:
40.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
ALA A  35
LYS A  37
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 1.01A 5ajqA-4ueuA:
24.0		 5ajqA-4ueuA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
GLY A  15
ALA A  35
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-2.9A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 1.04A 5ajqA-4ueuA:
24.0		 5ajqA-4ueuA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.90A 5bvwA-4ueuA:
30.2		 5bvwA-4ueuA:
39.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.85A 5bvwA-4ueuA:
30.2		 5bvwA-4ueuA:
39.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ARG A  12
LEU A  14
VAL A  22
ALA A  35
THR A  81
GLY A  87
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
 0.72A 5h2uA-4ueuA:
30.2		 5h2uA-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 LEU A  14
VAL A  22
ALA A  35
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.58A 5h2uA-4ueuA:
30.2		 5h2uA-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ARG A  12
LEU A  14
ALA A  35
ILE A  79
GLY A  87
LEU A 136
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.64A 5h2uC-4ueuA:
30.3		 5h2uC-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ARG A  12
LEU A  14
ALA A  35
THR A  81
GLY A  87
LEU A 136
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.67A 5h2uC-4ueuA:
30.3		 5h2uC-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 LEU A  14
VAL A  22
ALA A  35
ILE A  79
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.43A 5h2uD-4ueuA:
30.5		 5h2uD-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 LEU A  14
VAL A  22
ALA A  35
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.52A 5h2uD-4ueuA:
30.5		 5h2uD-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
ILE A  79
THR A  81
TYR A  83
ASP A  91
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
 0.61A 5hesA-4ueuA:
14.0		 5hesA-4ueuA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
THR A  81
TYR A  83
ASP A  91
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
None
 0.91A 5hesA-4ueuA:
14.0		 5hesA-4ueuA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
TYR A  83
ASP A  91
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
None
 0.78A 5hesB-4ueuA:
26.7		 5hesB-4ueuA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
LYS A  37
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 0.81A 5hi2A-4ueuA:
28.5		 5hi2A-4ueuA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
 0.45A 5hieA-4ueuA:
26.4		 5hieA-4ueuA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
 0.46A 5hieB-4ueuA:
26.6		 5hieB-4ueuA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 GLY A  15
VAL A  22
ALA A  35
LYS A  37
THR A  81
 ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
 0.52A 5hieC-4ueuA:
26.9		 5hieC-4ueuA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
 0.45A 5hieD-4ueuA:
26.7		 5hieD-4ueuA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
GLU A  52
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.48A 5i9xA-4ueuA:
33.5		 5i9xA-4ueuA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
TYR A  83
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.72A 5i9xA-4ueuA:
33.5		 5i9xA-4ueuA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.53A 5i9yA-4ueuA:
32.9		 5i9yA-4ueuA:
44.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 PHE A 199
ILE A 198
LEU A 194
ALA A 258
LEU A 107
 None
 1.24A 5km9B-4ueuA:
undetectable		 5km9B-4ueuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 GLY A  15
VAL A  22
ALA A  35
LYS A  37
GLU A  52
TYR A  83
GLY A  87
 ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
 0.72A 5mafA-4ueuA:
26.5		 5mafA-4ueuA:
15.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 10 LEU A  14
VAL A  22
ILE A  79
MET A  84
GLY A  87
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 (-3.5A)
 0.63A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 10 LEU A  14
VAL A  22
LYS A  37
GLU A  52
ILE A  79
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
 0.58A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 ALA A  35
LEU A  64
VAL A  65
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.46A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 10 LEU A  14
VAL A  22
ALA A  35
VAL A  65
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.59A 5n3hA-4ueuA:
24.7		 5n3hA-4ueuA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
ILE A  79
THR A  81
GLY A  87
LEU A 136
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.93A 5p9iA-4ueuA:
31.7		 5p9iA-4ueuA:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
 0.93A 5p9iA-4ueuA:
31.7		 5p9iA-4ueuA:
48.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
THR A  81
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
 0.78A 5vcyA-4ueuA:
25.2		 5vcyA-4ueuA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 LEU A  14
GLY A  15
VAL A  22
ALA A  35
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
 0.49A 5xv7A-4ueuA:
23.3		 5xv7A-4ueuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		5 / 12 LEU A  14
GLY A  15
VAL A  22
GLY A  87
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-3.5A)
None
 0.60A 5xv7A-4ueuA:
23.3		 5xv7A-4ueuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		6 / 12 LEU A  14
GLY A  15
VAL A  22
ALA A  35
LYS A  37
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.8A)
 0.65A 5yu9A-4ueuA:
28.3		 5yu9A-4ueuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
GLY A  15
ALA A  35
GLU A  52
MET A  56
TYR A  83
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
None
 1.25A 5zv2A-4ueuA:
30.5		 5zv2A-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
TYR A  83
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
None
 0.76A 5zv2A-4ueuA:
30.5		 5zv2A-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
MET A  56
TYR A  83
GLY A  87
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
None
 0.85A 5zv2A-4ueuA:
30.5		 5zv2A-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
 0.80A 5zv2B-4ueuA:
30.5		 5zv2B-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  56
GLY A  87
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
 0.91A 5zv2B-4ueuA:
30.5		 5zv2B-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.92A 6bsdA-4ueuA:
29.9		 6bsdA-4ueuA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
THR A  81
TYR A  83
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.86A 6bsdA-4ueuA:
29.9		 6bsdA-4ueuA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
TYR A  83
MET A  84
LEU A 136
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
None
 1.32A 6bsdA-4ueuA:
29.9		 6bsdA-4ueuA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  90
LEU A  93
ARG A  94
HIS A  99
 None
 1.01A 6e43A-4ueuA:
undetectable		 6e43A-4ueuA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  90
LEU A  93
ARG A  94
HIS A  99
 None
 1.01A 6e43B-4ueuA:
undetectable		 6e43B-4ueuA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  90
LEU A  93
ARG A  94
HIS A  99
 None
 1.00A 6e43C-4ueuA:
undetectable		 6e43C-4ueuA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 6 LEU A  90
LEU A  93
ARG A  94
HIS A  99
 None
 0.96A 6e43D-4ueuA:
undetectable		 6e43D-4ueuA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		10 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.65A 6fnmA-4ueuA:
34.0		 6fnmA-4ueuA:
41.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.07A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.88A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
ILE A  55
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.17A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
None
None
 1.04A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
None
None
 0.86A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.10A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.91A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 VAL A  22
ALA A  35
ILE A  55
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.19A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
 0.95A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
 0.80A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.07A 6hd6A-4ueuA:
22.4		 6hd6A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		9 / 12 VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.87A 6hd6A-4ueuA:
22.4		 6hd6A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
 0.87A 6hd6A-4ueuA:
22.4		 6hd6A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		7 / 12 VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
 0.71A 6hd6A-4ueuA:
22.4		 6hd6A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		4 / 5 LEU A  14
ILE A  55
MET A  84
GLY A  87
 ACP  A1264 ( 4.5A)
None
None
ACP  A1264 (-3.5A)
 0.84A 6hd6A-4ueuA:
22.4		 6hd6A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
 1.04A 6hd6B-4ueuA:
32.0		 6hd6B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
 0.91A 6hd6B-4ueuA:
32.0		 6hd6B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL
(synthetic
construct) 		8 / 12 LEU A  14
VAL A  22
ALA A  35
MET A  56
VAL A  65
THR A  81
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
 1.05A 6hd6B-4ueuA:
32.0		 6hd6B-4ueuA:
30.86