SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 8 TYR A 308
TYR A 387
LEU A  96
GLU A  91
 None
 1.11A 1i7zA-4uf4A:
undetectable		 1i7zA-4uf4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 9 ASP A  44
GLU A  46
SER A 272
SER A 268
THR A 274
 None
 1.00A 1m4gB-4uf4A:
undetectable		 1m4gB-4uf4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 8 ASP A  44
GLU A  46
SER A 272
THR A 274
 None
 0.88A 1m4iA-4uf4A:
undetectable		 1m4iA-4uf4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 7 SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
O2V  A1419 (-1.8A)
 1.26A 2c8aA-4uf4A:
undetectable		 2c8aA-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 7 GLY A 388
SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
None
O2V  A1419 (-1.8A)
 1.42A 2c8aB-4uf4A:
undetectable		 2c8aB-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 6 SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
O2V  A1419 (-1.8A)
 1.32A 2c8aC-4uf4A:
undetectable		 2c8aC-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 7 GLY A 388
SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
None
O2V  A1419 (-1.8A)
 1.46A 2c8aD-4uf4A:
undetectable		 2c8aD-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 8 ILE A 303
SER A 304
ASP A 175
SER A 188
 None
 0.81A 2cdqA-4uf4A:
2.1		 2cdqA-4uf4A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 5 SER A 307
LEU A 390
GLY A 388
ARG A 234
 None
 0.94A 2j2pA-4uf4A:
undetectable
2j2pB-4uf4A:
undetectable		 2j2pA-4uf4A:
19.51
2j2pB-4uf4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 6 ARG A 234
SER A 307
LEU A 390
GLY A 388
 None
 1.01A 2j2pA-4uf4A:
undetectable
2j2pC-4uf4A:
undetectable		 2j2pA-4uf4A:
19.51
2j2pC-4uf4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 6 ARG A 234
SER A 307
LEU A 390
GLY A 388
 None
 0.98A 2j2pD-4uf4A:
undetectable
2j2pF-4uf4A:
undetectable		 2j2pD-4uf4A:
19.51
2j2pF-4uf4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFT_A_SORA1419_0
(XYLITOL OXIDASE)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 12 VAL A 143
PHE A 131
GLN A 198
GLU A 138
THR A 197
 None
 1.37A 2vftA-4uf4A:
1.1		 2vftA-4uf4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		3 / 3 GLU A 380
HIS A 179
GLU A 182
 O2V  A1419 (-1.8A)
ZN  A1420 ( 3.1A)
ZN  A1420 (-1.9A)
 0.83A 2x45B-4uf4A:
undetectable		 2x45B-4uf4A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		3 / 3 GLU A 380
HIS A 179
GLU A 182
 O2V  A1419 (-1.8A)
ZN  A1420 ( 3.1A)
ZN  A1420 (-1.9A)
 0.86A 2x45C-4uf4A:
undetectable		 2x45C-4uf4A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 11 ALA A 339
LEU A 332
ILE A 303
PHE A 379
THR A 338
 None
 1.26A 3jw5A-4uf4A:
undetectable		 3jw5A-4uf4A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 5 THR A 239
GLY A 225
PRO A 223
ASN A 222
 None
 0.87A 3u8qA-4uf4A:
undetectable		 3u8qA-4uf4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 6 THR A 239
GLY A 225
ASN A 222
GLY A 154
 None
 0.88A 4fjpA-4uf4A:
undetectable		 4fjpA-4uf4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 6 THR A 239
GLY A 225
PRO A 223
ASN A 222
 None
 0.87A 4fjpA-4uf4A:
undetectable		 4fjpA-4uf4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		3 / 3 ARG A  66
ASP A  51
TRP A  53
 None
 0.84A 4xdqA-4uf4A:
undetectable		 4xdqA-4uf4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 6 PHE A 379
LEU A 311
SER A 333
GLY A 351
 None
 1.12A 5o4yF-4uf4A:
undetectable		 5o4yF-4uf4A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 12 GLY A 260
GLY A 265
GLY A 262
ALA A 360
TYR A 358
 None
None
None
O2V  A1419 ( 3.7A)
O2V  A1419 (-4.6A)
 0.81A 5x7fA-4uf4A:
undetectable		 5x7fA-4uf4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 8 HIS A  23
ARG A 181
ASP A  51
GLU A 273
 None
 1.13A 6mn4A-4uf4A:
undetectable		 6mn4A-4uf4A:
20.75