SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ufs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 343
LEU A 359
THR A 393
PHE A 394
LEU A 403
 None
 1.10A 1bzfA-4ufsA:
undetectable		 1bzfA-4ufsA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 217
LEU A 246
LEU A 212
LEU A 188
 None
 0.93A 1errA-4ufsA:
undetectable		 1errA-4ufsA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 8 HIS A 128
TYR A 152
LEU A 126
GLU A 132
 None
 1.05A 1i7zA-4ufsA:
undetectable		 1i7zA-4ufsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 9 LEU A 381
LEU A 367
VAL A 347
LEU A 354
PHE A 370
 None
 1.18A 1tbfA-4ufsA:
undetectable		 1tbfA-4ufsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 7 PHE A 249
PHE A 288
LEU A 307
PHE A 264
 None
 1.15A 1wrlE-4ufsA:
undetectable		 1wrlE-4ufsA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 PHE A 206
LEU A 241
ILE A 198
LEU A 225
LEU A 239
 None
 1.01A 1xdkF-4ufsA:
undetectable		 1xdkF-4ufsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
R-SPONDIN-2
(Homo
sapiens) 		4 / 6 ALA B  87
HIS A 265
ASP A 290
TYR A 289
 None
 1.12A 2dpzA-4ufsB:
undetectable		 2dpzA-4ufsB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 9 LEU A 236
LEU A 256
ILE A 253
PHE A 230
LEU A 241
 None
 1.15A 2f7aB-4ufsA:
undetectable		 2f7aB-4ufsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 11 LEU A  97
LEU A  95
PRO A  83
ASN A  84
LEU A 126
 None
 1.15A 2ft9A-4ufsA:
undetectable		 2ft9A-4ufsA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 314
ALA A 315
ILE A 272
PRO A 322
ILE A 318
 None
 0.96A 2hs1A-4ufsA:
undetectable		 2hs1A-4ufsA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 THR A 334
ASP A 380
ASN A 404
ASP A 428
 None
 1.28A 2okcA-4ufsA:
undetectable		 2okcA-4ufsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 452
LEU A 456
PRO A 474
SER A 435
ALA A 406
 None
 1.14A 3i5uB-4ufsA:
undetectable		 3i5uB-4ufsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
R-SPONDIN-2
(Homo
sapiens) 		4 / 4 ARG A 165
ASP B 102
GLY B 116
THR B 138
 None
 1.27A 3k4vB-4ufsA:
undetectable		 3k4vB-4ufsA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 236
LEU A 262
THR A 255
ILE A 253
ALA A 252
 None
 0.84A 3mdvB-4ufsA:
undetectable		 3mdvB-4ufsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		3 / 3 TYR A 361
HIS A 383
ARG A 382
 None
 0.99A 4e7bC-4ufsA:
undetectable		 4e7bC-4ufsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 PHE A 288
ILE A 293
PRO A 292
PHE A 264
 None
 1.27A 4fgkA-4ufsA:
undetectable		 4fgkA-4ufsA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 PHE A 182
MET A 191
ILE A 177
VAL A 129
 None
 1.41A 4mk4B-4ufsA:
undetectable		 4mk4B-4ufsA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 256
ASN A 280
LEU A 241
ILE A 286
 None
 1.10A 4okxA-4ufsA:
undetectable		 4okxA-4ufsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 8 PHE A 230
ILE A 253
GLY A 263
ILE A 286
 None
 0.98A 4qogA-4ufsA:
undetectable
4qogB-4ufsA:
undetectable		 4qogA-4ufsA:
17.17
4qogB-4ufsA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 4 SER A  74
GLU A  94
SER A  69
ASP A  51
 None
 1.27A 4xucA-4ufsA:
undetectable		 4xucA-4ufsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 ILE A 460
PHE A 418
LEU A 429
LEU A 434
LEU A 456
 None
 1.21A 4xumA-4ufsA:
undetectable		 4xumA-4ufsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 343
LEU A 403
ILE A 379
LEU A 376
PRO A 352
 None
 1.11A 5ienA-4ufsA:
undetectable		 5ienA-4ufsA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
R-SPONDIN-2
(Homo
sapiens) 		4 / 5 PRO B  88
HIS A 216
LEU A 246
TYR A 289
 None
 1.43A 5igjA-4ufsB:
undetectable		 5igjA-4ufsB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
R-SPONDIN-2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG A 144
PHE B  60
ARG B  86
 None
 1.23A 5y9yA-4ufsA:
undetectable		 5y9yA-4ufsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 11 ILE A 410
ALA A 406
ASP A 428
LEU A 367
ILE A 386
 None
 1.04A 5z6mA-4ufsA:
undetectable		 5z6mA-4ufsA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 217
LEU A 193
ALA A 252
LEU A 241
LEU A 259
 None
 1.10A 6ew0B-4ufsA:
undetectable		 6ew0B-4ufsA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 217
LEU A 193
ALA A 252
LEU A 241
LEU A 259
 None
 1.10A 6ew0D-4ufsA:
undetectable		 6ew0D-4ufsA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 217
LEU A 193
ALA A 252
LEU A 241
LEU A 259
 None
 1.10A 6ew0H-4ufsA:
undetectable		 6ew0H-4ufsA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 217
LEU A 193
ALA A 252
LEU A 241
LEU A 259
 None
 1.09A 6ew0I-4ufsA:
undetectable		 6ew0I-4ufsA:
11.21