SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ug4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 SER A  60
PHE A  61
LEU A 346
TYR A  86
LEU A 321
 None
 1.37A 1p33B-4ug4A:
undetectable		 1p33B-4ug4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 11 THR A  70
SER A  68
PHE A 454
SER A  60
PHE A 312
 None
 1.45A 1q23G-4ug4A:
undetectable		 1q23G-4ug4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A  69
VAL A 357
TRP A 360
 None
 1.25A 1qw6A-4ug4A:
undetectable		 1qw6A-4ug4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A  69
VAL A 357
TRP A 360
 None
 1.23A 1qwcA-4ug4A:
undetectable		 1qwcA-4ug4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A  69
VAL A 357
TRP A 360
 None
 1.24A 1vagA-4ug4A:
undetectable		 1vagA-4ug4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A 445
SER A 338
TYR A  48
 None
 0.76A 1x70A-4ug4A:
undetectable		 1x70A-4ug4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A  69
VAL A 357
TRP A 360
 None
 1.19A 1zviA-4ug4A:
undetectable		 1zviA-4ug4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  53
SER A 242
ILE A 239
ALA A 387
ALA A 385
 None
 1.27A 2japC-4ug4A:
2.1		 2japC-4ug4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A 510
ARG A 507
PRO A 509
 None
 1.05A 2wljA-4ug4A:
undetectable		 2wljA-4ug4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 8 TYR A 123
ASN A  75
PRO A  52
PHE A 312
 None
 1.46A 3bjwD-4ug4A:
undetectable		 3bjwD-4ug4A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 GLY A 363
ASP A 341
SER A 338
 None
 0.61A 3brfA-4ug4A:
undetectable		 3brfA-4ug4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 289
LEU A 276
ILE A 277
LEU A 346
TYR A  86
 None
 1.37A 3gwxB-4ug4A:
undetectable		 3gwxB-4ug4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  83
ALA A  57
SER A  60
GLY A  64
LEU A 340
 None
 0.88A 3hs6B-4ug4A:
undetectable		 3hs6B-4ug4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 295
GLY A 315
GLU A 223
GLU A 303
 None
 1.27A 3raeB-4ug4A:
undetectable
3raeD-4ug4A:
1.7		 3raeB-4ug4A:
21.80
3raeD-4ug4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 5 THR A   2
GLY A   4
PRO A   6
TYR A  95
 None
 1.24A 3u8qA-4ug4A:
undetectable		 3u8qA-4ug4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 10 THR A  70
SER A  68
PHE A 454
SER A  60
PHE A 312
 None
 1.34A 3u9fD-4ug4A:
undetectable
3u9fF-4ug4A:
undetectable		 3u9fD-4ug4A:
16.54
3u9fF-4ug4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 THR A  70
SER A  68
PHE A 454
SER A  60
PHE A 312
 None
 1.45A 3u9fH-4ug4A:
undetectable
3u9fI-4ug4A:
undetectable		 3u9fH-4ug4A:
16.54
3u9fI-4ug4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 5 TYR A 204
VAL A 150
SER A 258
GLY A 302
 None
 1.43A 3v4tA-4ug4A:
undetectable
3v4tD-4ug4A:
2.1		 3v4tA-4ug4A:
22.00
3v4tD-4ug4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 10 HIS A 297
ASP A  14
PRO A 124
HIS A 104
TYR A 123
 MN  A1513 (-3.5A)
MN  A1513 (-2.4A)
None
None
None
 1.38A 4bz6A-4ug4A:
undetectable		 4bz6A-4ug4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A 297
ASP A  14
PRO A 124
HIS A 104
TYR A 123
 MN  A1513 (-3.5A)
MN  A1513 (-2.4A)
None
None
None
 1.38A 4bz6A-4ug4A:
undetectable
4bz6B-4ug4A:
undetectable		 4bz6A-4ug4A:
22.57
4bz6B-4ug4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 10 HIS A 297
ASP A  14
PRO A 124
HIS A 104
TYR A 123
 MN  A1513 (-3.5A)
MN  A1513 (-2.4A)
None
None
None
 1.36A 4bz6D-4ug4A:
undetectable		 4bz6D-4ug4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 420
GLN A 232
ASP A 299
MET A 300
GLY A 302
 None
 1.50A 4j7xA-4ug4A:
2.9		 4j7xA-4ug4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 420
GLN A 232
ASP A 299
MET A 300
GLY A 302
 None
 1.48A 4j7xF-4ug4A:
2.3		 4j7xF-4ug4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 8 HIS A 297
LYS A 309
TYR A 262
ASP A  14
 MN  A1513 (-3.5A)
None
None
MN  A1513 (-2.4A)
 0.88A 4k0bB-4ug4A:
undetectable		 4k0bB-4ug4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 8 HIS A 297
LYS A 309
TYR A 262
ASP A  14
 MN  A1513 (-3.5A)
None
None
MN  A1513 (-2.4A)
 0.89A 4l7iB-4ug4A:
undetectable		 4l7iB-4ug4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 7 PHE A 313
LEU A 306
MET A 240
ALA A 387
 None
 0.84A 4rjdB-4ug4A:
undetectable		 4rjdB-4ug4A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 4 ALA A 347
VAL A 342
GLY A  64
THR A 361
 None
 1.11A 4ubeA-4ug4A:
undetectable		 4ubeA-4ug4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 242
ARG A 304
GLY A 302
GLU A 303
 None
 1.20A 5btiA-4ug4A:
undetectable
5btiB-4ug4A:
undetectable		 5btiA-4ug4A:
22.13
5btiB-4ug4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 242
ARG A 304
GLY A 302
GLU A 303
 None
 1.18A 5btiC-4ug4A:
undetectable
5btiD-4ug4A:
undetectable		 5btiC-4ug4A:
22.13
5btiD-4ug4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A  69
VAL A 357
TRP A 360
 None
 1.25A 5fvoA-4ug4A:
undetectable		 5fvoA-4ug4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A  36
LEU A  34
ILE A 291
ALA A 324
ILE A  11
 None
 1.22A 5nm5B-4ug4A:
undetectable		 5nm5B-4ug4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		5 / 9 VAL A 273
LEU A  34
VAL A  13
HIS A 199
ILE A  11
 None
 1.18A 5om2A-4ug4A:
undetectable
5om2B-4ug4A:
undetectable		 5om2A-4ug4A:
11.02
5om2B-4ug4A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 5 VAL A 168
HIS A 482
LEU A 193
ASP A 121
 None
 1.37A 5vcvA-4ug4A:
undetectable		 5vcvA-4ug4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A  13
LEU A 306
PHE A 308
LEU A 301
 None
 1.06A 6aycA-4ug4A:
undetectable		 6aycA-4ug4A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		3 / 3 TYR A 245
ASP A 244
GLN A 246
 None
 0.96A 6g1pA-4ug4A:
undetectable		 6g1pA-4ug4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 5 GLY A 107
HIS A 112
SER A  82
SER A  81
 None
 1.06A 6jmjA-4ug4A:
undetectable		 6jmjA-4ug4A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ug4 CHOLINE SULFATASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 107
HIS A 112
SER A  82
SER A  81
 None
 1.04A 6jogA-4ug4A:
undetectable		 6jogA-4ug4A:
14.65