SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uhh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		5 / 10 GLY A  34
PHE A  35
SER A 101
MET A 102
HIS A 250
 None
None
CAD  A1275 (-3.6A)
None
None
 0.72A 1a8uA-4uhhA:
32.4		 1a8uA-4uhhA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		5 / 10 GLY A  34
PHE A  35
SER A 101
MET A 102
HIS A 250
 None
None
CAD  A1275 (-3.6A)
None
None
 0.72A 1a8uB-4uhhA:
32.3		 1a8uB-4uhhA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 4 VAL A  32
ALA A 107
LEU A 118
PHE A 110
 None
 1.23A 1q97B-4uhhA:
undetectable		 1q97B-4uhhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		6 / 12 LEU A 100
GLY A 103
VAL A  57
LEU A  31
GLY A  98
GLY A  99
 None
 1.43A 1uakA-4uhhA:
undetectable		 1uakA-4uhhA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		5 / 12 PHE A 168
GLY A 219
THR A 167
GLY A  34
LEU A 100
 None
 0.99A 2hw2A-4uhhA:
undetectable		 2hw2A-4uhhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ILE A   7
ARG A 117
ILE A  56
PHE A  20
 None
 1.11A 2q72A-4uhhA:
undetectable		 2q72A-4uhhA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 5 LEU A  82
ARG A 117
ALA A  79
ILE A  95
 None
 1.03A 2qhfA-4uhhA:
undetectable		 2qhfA-4uhhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  98
ILE A  95
LEU A 100
ASP A 125
LEU A 217
 None
 1.19A 3q87B-4uhhA:
undetectable		 3q87B-4uhhA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 7 LEU A  31
GLY A 104
ALA A 107
PHE A 108
 None
 0.79A 3tehB-4uhhA:
undetectable		 3tehB-4uhhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		5 / 12 ILE A 224
LEU A 251
LEU A  37
ILE A 182
MET A 197
 CAD  A1275 (-4.3A)
None
None
None
CAD  A1275 ( 4.2A)
 0.78A 3uvvA-4uhhA:
undetectable		 3uvvA-4uhhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 7 ILE A 154
ASP A  38
LEU A  37
PHE A  35
 None
 0.74A 4iqqC-4uhhA:
undetectable		 4iqqC-4uhhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.34A 4w5qA-4uhhA:
4.0		 4w5qA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.36A 4w5rA-4uhhA:
3.9		 4w5rA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.35A 4w5tA-4uhhA:
2.2		 4w5tA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.35A 4z4cA-4uhhA:
2.2		 4z4cA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.33A 4z4fA-4uhhA:
2.1		 4z4fA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 5 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.36A 4z4gA-4uhhA:
undetectable		 4z4gA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.36A 4z4iA-4uhhA:
3.9		 4z4iA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		6 / 9 ALA A 128
LEU A 207
LEU A 210
ALA A 111
LEU A 121
LEU A 123
 None
 0.95A 4z91F-4uhhA:
undetectable
4z91G-4uhhA:
undetectable
4z91H-4uhhA:
undetectable
4z91I-4uhhA:
undetectable
4z91J-4uhhA:
undetectable		 4z91F-4uhhA:
21.22
4z91G-4uhhA:
21.22
4z91H-4uhhA:
21.22
4z91I-4uhhA:
21.22
4z91J-4uhhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		6 / 9 LEU A 121
ALA A 107
ALA A 128
LEU A 207
LEU A 210
ALA A 111
 None
 0.92A 4z91F-4uhhA:
undetectable
4z91G-4uhhA:
undetectable
4z91H-4uhhA:
undetectable
4z91I-4uhhA:
undetectable
4z91J-4uhhA:
undetectable		 4z91F-4uhhA:
21.22
4z91G-4uhhA:
21.22
4z91H-4uhhA:
21.22
4z91I-4uhhA:
21.22
4z91J-4uhhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		6 / 9 LEU A 121
ALA A 107
LEU A 123
LEU A 207
LEU A 210
ALA A 111
 None
 0.88A 4z91F-4uhhA:
undetectable
4z91G-4uhhA:
undetectable
4z91H-4uhhA:
undetectable
4z91I-4uhhA:
undetectable
4z91J-4uhhA:
undetectable		 4z91F-4uhhA:
21.22
4z91G-4uhhA:
21.22
4z91H-4uhhA:
21.22
4z91I-4uhhA:
21.22
4z91J-4uhhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		6 / 9 LEU A 123
ALA A 128
LEU A 207
LEU A 210
LEU A 121
ALA A 107
 None
 0.98A 4z91F-4uhhA:
undetectable
4z91G-4uhhA:
undetectable
4z91H-4uhhA:
undetectable
4z91I-4uhhA:
undetectable
4z91J-4uhhA:
undetectable		 4z91F-4uhhA:
21.22
4z91G-4uhhA:
21.22
4z91H-4uhhA:
21.22
4z91I-4uhhA:
21.22
4z91J-4uhhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		7 / 9 LEU A 207
LEU A 210
ALA A 111
LEU A 121
ALA A 107
LEU A 123
ALA A 128
 None
 0.94A 4z91F-4uhhA:
undetectable
4z91G-4uhhA:
undetectable
4z91H-4uhhA:
undetectable
4z91I-4uhhA:
undetectable
4z91J-4uhhA:
undetectable		 4z91F-4uhhA:
21.22
4z91G-4uhhA:
21.22
4z91H-4uhhA:
21.22
4z91I-4uhhA:
21.22
4z91J-4uhhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		6 / 9 LEU A 210
ALA A 111
LEU A 121
ALA A 107
LEU A 123
LEU A 207
 None
 0.66A 4z91F-4uhhA:
undetectable
4z91G-4uhhA:
undetectable
4z91H-4uhhA:
undetectable
4z91I-4uhhA:
undetectable
4z91J-4uhhA:
undetectable		 4z91F-4uhhA:
21.22
4z91G-4uhhA:
21.22
4z91H-4uhhA:
21.22
4z91I-4uhhA:
21.22
4z91J-4uhhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		5 / 10 ILE A  95
GLY A 120
THR A 214
LEU A 118
LEU A 123
 None
 1.08A 5fhzC-4uhhA:
undetectable		 5fhzC-4uhhA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		4 / 7 ILE A 154
ASP A  38
LEU A  37
PHE A  35
 None
 0.87A 5nooB-4uhhA:
undetectable		 5nooB-4uhhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4uhh ESTERASE
(Thermogutta
terrifontis) 		5 / 9 ILE A 245
ALA A 248
GLY A 249
LEU A 251
ARG A 259
 None
 1.18A 6nm4B-4uhhA:
undetectable		 6nm4B-4uhhA:
19.93