SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uhm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		4 / 4 LEU A 433
SER A  43
LEU A 382
LEU A 357
 None
 0.91A 1yajA-4uhmA:
undetectable		 1yajA-4uhmA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 LEU A  57
ARG A 414
SER A 403
GLY A  64
LEU A 357
 None
 1.22A 2lbdA-4uhmA:
undetectable		 2lbdA-4uhmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		3 / 3 LEU A 182
PRO A 183
ARG A 244
 None
None
GOL  A1455 (-3.3A)
 0.58A 2qd5A-4uhmA:
undetectable		 2qd5A-4uhmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		4 / 8 ILE A  72
GLU A 348
LEU A 350
GLY A 293
 None
 0.89A 2qqdB-4uhmA:
undetectable
2qqdC-4uhmA:
undetectable		 2qqdB-4uhmA:
12.89
2qqdC-4uhmA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		6 / 10 LEU A 444
VAL A 447
GLY A 446
LEU A 420
LEU A 406
ALA A 402
 None
 1.48A 2v3kA-4uhmA:
undetectable		 2v3kA-4uhmA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		3 / 3 LEU A  57
VAL A 261
ARG A 267
 None
PLP  A1458 (-4.1A)
None
 0.84A 3b0wB-4uhmA:
undetectable		 3b0wB-4uhmA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.14A 3kkzA-4uhmA:
undetectable		 3kkzA-4uhmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 ALA A  65
GLY A  66
ALA A  73
ASN A 292
LEU A 342
 None
 1.16A 3qxyA-4uhmA:
undetectable		 3qxyA-4uhmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 11 ALA A  65
GLY A  66
ALA A  73
ASN A 292
LEU A 342
 None
 1.19A 3rc0A-4uhmA:
undetectable		 3rc0A-4uhmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 ALA A  65
GLY A  66
ALA A  73
ASN A 292
LEU A 342
 None
 1.20A 3rc0B-4uhmA:
undetectable		 3rc0B-4uhmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLY A 164
GLY A 152
ASN A 169
VAL A 179
GLY A 160
 None
None
CL  A1459 (-3.2A)
None
None
 0.98A 3sglA-4uhmA:
undetectable		 3sglA-4uhmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.13A 3sxjA-4uhmA:
undetectable		 3sxjA-4uhmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.14A 3sxjB-4uhmA:
undetectable		 3sxjB-4uhmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.20A 3t7sB-4uhmA:
undetectable		 3t7sB-4uhmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.18A 3t7sD-4uhmA:
undetectable		 3t7sD-4uhmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		4 / 4 ASN A 292
ALA A  65
GLY A  64
THR A 425
 None
 1.18A 4bboC-4uhmA:
undetectable		 4bboC-4uhmA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		4 / 4 LYS A 429
ALA A 428
SER A  56
THR A 425
 None
 1.29A 4i89B-4uhmA:
undetectable		 4i89B-4uhmA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 LEU A 186
GLY A 416
GLY A 417
ASN A 169
GLY A 168
 None
None
None
CL  A1459 (-3.2A)
None
 0.96A 4n09D-4uhmA:
2.7		 4n09D-4uhmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		4 / 5 GLY A 152
HIS A 154
GLY A 148
GLU A 226
 None
None
None
PLP  A1458 (-4.0A)
 1.08A 4v20A-4uhmA:
undetectable		 4v20A-4uhmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		4 / 6 PHE A 400
PRO A 399
ARG A 391
ILE A 396
 None
 1.17A 5ih0A-4uhmA:
undetectable		 5ih0A-4uhmA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		3 / 3 GLY A  64
THR A  62
ASN A 292
 None
 0.59A 5odiG-4uhmA:
undetectable		 5odiG-4uhmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		4 / 6 ASN A 427
TYR A  54
LEU A 382
SER A  58
 None
 1.10A 6a7pB-4uhmA:
undetectable		 6a7pB-4uhmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 ASN A 285
GLY A 160
GLY A 155
GLU A 122
ILE A 128
 None
None
PLP  A1458 (-3.5A)
None
None
 1.00A 6ectA-4uhmA:
undetectable		 6ectA-4uhmA:
24.38