SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ui2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens) 		5 / 12 LEU D 291
ALA D 234
VAL D 269
VAL D 280
VAL D 282
 None
 0.87A 2ieoB-4ui2D:
undetectable		 2ieoB-4ui2D:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens) 		5 / 11 LEU D 291
ALA D 234
VAL D 269
VAL D 280
VAL D 282
 None
 0.95A 2nnpB-4ui2D:
undetectable		 2nnpB-4ui2D:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA D 300
ASP D 176
GLY C 164
LEU C 165
LEU C 161
 None
 1.36A 2nv4B-4ui2D:
undetectable		 2nv4B-4ui2D:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens) 		3 / 3 TYR C 105
TYR C  88
ILE C 112
 None
 0.79A 3eteA-4ui2C:
undetectable
3eteB-4ui2C:
undetectable		 3eteA-4ui2C:
13.46
3eteB-4ui2C:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens) 		5 / 10 GLY D 286
ILE D 216
PHE C 162
GLY C 167
PHE C 166
 None
 1.35A 3ko0R-4ui2D:
undetectable
3ko0T-4ui2D:
undetectable		 3ko0R-4ui2D:
15.45
3ko0T-4ui2D:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens) 		5 / 10 LEU D 291
ALA D 234
VAL D 269
VAL D 231
VAL D 280
 None
 0.97A 3oxwA-4ui2D:
undetectable		 3oxwA-4ui2D:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens) 		5 / 12 LEU D 291
ALA D 234
ASP D 238
VAL D 269
VAL D 282
 None
 0.79A 3so9B-4ui2D:
undetectable		 3so9B-4ui2D:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens) 		4 / 5 TYR C  88
ILE C  56
THR C  92
HIS C 106
 None
 1.08A 4oltB-4ui2C:
undetectable		 4oltB-4ui2C:
20.82