SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ui9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 8 SER C 262
VAL C 266
SER C 267
ASN C 299
 None
 1.05A 1hwiB-4ui9C:
undetectable		 1hwiB-4ui9C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 8 SER C 262
VAL C 266
SER C 267
ASN C 299
 None
 1.05A 1hwkA-4ui9C:
undetectable		 1hwkA-4ui9C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 8 SER C 262
VAL C 266
SER C 267
ASN C 299
 None
 1.03A 1hwkC-4ui9C:
undetectable		 1hwkC-4ui9C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 8 SER C 262
VAL C 266
SER C 267
ASN C 299
 None
 1.03A 1hwkD-4ui9C:
undetectable		 1hwkD-4ui9C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 13
CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		5 / 12 ASP M  22
GLU M  27
SER C 317
TYR C 341
TYR C 353
 None
 1.48A 1maaA-4ui9M:
undetectable		 1maaA-4ui9M:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 5 LEU N 428
GLN N 437
THR N 434
LEU N 386
 None
 1.22A 3ce6D-4ui9N:
undetectable		 3ce6D-4ui9N:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		3 / 3 GLN N 437
THR N 434
LEU N 386
 None
 0.69A 3ondA-4ui9N:
undetectable		 3ondA-4ui9N:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		3 / 3 GLN N 437
THR N 434
LEU N 386
 None
 0.68A 3ondB-4ui9N:
undetectable		 3ondB-4ui9N:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 13
CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		5 / 11 VAL C 336
GLY C 338
ALA C 350
LEU C 319
PRO M  25
 None
 1.02A 3sm2B-4ui9C:
undetectable		 3sm2B-4ui9C:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 6 SER C  51
TYR C 173
PHE C 170
PHE C 116
 None
 1.32A 4awuA-4ui9C:
undetectable		 4awuA-4ui9C:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 5 PHE C  94
TYR C 120
THR C  43
PHE C 116
 None
 1.01A 4jx1E-4ui9C:
undetectable		 4jx1E-4ui9C:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 11
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU N 705
VAL N 704
VAL B   3
VAL N 648
 None
 1.06A 4l4bA-4ui9N:
undetectable		 4l4bA-4ui9N:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		5 / 10 GLY C 176
VAL C 177
GLU C 208
VAL C 178
LEU C 212
 None
 1.18A 4yb6A-4ui9C:
undetectable
4yb6E-4ui9C:
undetectable		 4yb6A-4ui9C:
21.39
4yb6E-4ui9C:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		5 / 10 GLY C 176
VAL C 177
GLU C 208
VAL C 178
LEU C 212
 None
 1.19A 4yb6B-4ui9C:
undetectable
4yb6C-4ui9C:
undetectable		 4yb6B-4ui9C:
21.39
4yb6C-4ui9C:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		5 / 10 LEU C 212
GLY C 176
VAL C 177
GLU C 208
VAL C 178
 None
 1.19A 4yb6B-4ui9C:
undetectable
4yb6F-4ui9C:
undetectable		 4yb6B-4ui9C:
21.39
4yb6F-4ui9C:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 7 SER C 304
TYR C 308
HIS C 347
TYR C 364
 None
 1.50A 5dlvB-4ui9C:
undetectable		 5dlvB-4ui9C:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		3 / 3 SER C  51
SER C  55
PHE C 170
 None
 0.93A 5mugA-4ui9C:
undetectable		 5mugA-4ui9C:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 6 ILE C 244
ALA C 247
LEU C 248
ILE C 269
 None
 0.84A 5mvmB-4ui9C:
2.5
5mvmC-4ui9C:
2.5		 5mvmB-4ui9C:
9.72
5mvmC-4ui9C:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		5 / 9 LEU C 405
ALA C 401
ASP C 398
HIS C 390
ILE C 385
 None
 1.16A 5om2A-4ui9C:
undetectable
5om2B-4ui9C:
undetectable		 5om2A-4ui9C:
9.20
5om2B-4ui9C:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 7 VAL C 191
VAL C 198
GLY C 171
TYR C 173
 None
 0.86A 5x80C-4ui9C:
undetectable
5x80D-4ui9C:
undetectable		 5x80C-4ui9C:
13.90
5x80D-4ui9C:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4ui9 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 11
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B  32
GLY B  41
ASN B  31
SER N 597
CYH B  34
 None
None
None
None
ZN  B 103 (-3.1A)
 1.31A 5yf0A-4ui9B:
undetectable		 5yf0A-4ui9B:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		4 / 6 PHE C 513
ARG C 514
LEU C 516
GLN C 518
 None
 1.08A 6b89B-4ui9C:
undetectable		 6b89B-4ui9C:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens) 		5 / 10 TYR C 364
ASP C 301
THR C 369
GLY C 338
GLU C 374
 None
 1.45A 6mb9D-4ui9C:
undetectable		 6mb9D-4ui9C:
11.11