SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uid SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A 524
ALA A 519
ASP A 521
PHE A 489
LEU A 452
 None
 1.44A 4eilA-4uidA:
undetectable		 4eilA-4uidA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uid SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 524
ALA A 519
ASP A 521
PHE A 489
LEU A 452
 None
 1.47A 4eilB-4uidA:
undetectable		 4eilB-4uidA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uid SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 524
ALA A 519
ASP A 521
PHE A 489
LEU A 452
 None
 1.48A 4kyaB-4uidA:
undetectable		 4kyaB-4uidA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uid SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 524
ALA A 519
ASP A 521
PHE A 489
LEU A 452
 None
 1.45A 4kyaC-4uidA:
undetectable		 4kyaC-4uidA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uid SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 524
ALA A 519
ASP A 521
PHE A 489
LEU A 452
 None
 1.47A 4kyaD-4uidA:
undetectable		 4kyaD-4uidA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uid SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 524
ALA A 519
ASP A 521
PHE A 489
LEU A 452
 None
 1.47A 4kyaF-4uidA:
undetectable		 4kyaF-4uidA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uid SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A 524
ALA A 519
ASP A 521
PHE A 489
LEU A 452
 None
 1.44A 4kyaG-4uidA:
undetectable		 4kyaG-4uidA:
18.27