SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A1069
ALA A1025
ALA A1026
ALA A1032
ILE A1093
 None
 1.16A 2aclC-4uieA:
undetectable		 2aclC-4uieA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 891
THR A 903
THR A 949
VAL A 951
 None
 0.87A 4ik7A-4uieA:
undetectable		 4ik7A-4uieA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 891
THR A 903
THR A 949
VAL A 951
 None
 0.80A 4ik7B-4uieA:
undetectable		 4ik7B-4uieA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 780
ALA A 784
LEU A 783
GLY A 848
ILE A 869
 None
 1.11A 4kt0A-4uieA:
undetectable
4kt0J-4uieA:
undetectable		 4kt0A-4uieA:
18.87
4kt0J-4uieA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 786
ASN A 789
LEU A 787
ALA A 788
LEU A 774
 None
 1.11A 4ltwA-4uieA:
undetectable		 4ltwA-4uieA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 812
LYS A 768
ALA A 788
 None
 1.47A 4ot2A-4uieA:
undetectable		 4ot2A-4uieA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 774
VAL A 851
ILE A 831
ASN A 789
LEU A 771
 None
 1.20A 4yvpB-4uieA:
undetectable		 4yvpB-4uieA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 859
VAL A 876
ILE A 772
LEU A 816
LEU A 790
 None
 1.10A 4yvpB-4uieA:
undetectable		 4yvpB-4uieA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A1022
ALA A1024
VAL A1061
GLY A1057
THR A1009
 None
 1.39A 5w5vA-4uieA:
undetectable		 5w5vA-4uieA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4uie SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 VAL A 876
LEU A 859
LEU A 861
LEU A 783
 None
 1.07A 6f6sA-4uieA:
undetectable
6f6sB-4uieA:
undetectable		 6f6sA-4uieA:
13.58
6f6sB-4uieA:
14.24