SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uij'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1
(Homo
sapiens) 		4 / 6 TYR A 123
GLY A  72
PHE A  70
SER A  71
 None
 1.23A 2a3cB-4uijA:
undetectable		 2a3cB-4uijA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1
(Homo
sapiens) 		4 / 8 GLY A 119
GLU A 120
ALA A 121
THR A  95
 None
 0.69A 2dtjA-4uijA:
undetectable
2dtjB-4uijA:
undetectable		 2dtjA-4uijA:
25.57
2dtjB-4uijA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1
(Homo
sapiens) 		5 / 9 ILE A  96
GLY A 119
GLU A 120
ALA A 121
THR A  95
 None
 1.01A 2dtjA-4uijA:
undetectable
2dtjB-4uijA:
undetectable		 2dtjA-4uijA:
25.57
2dtjB-4uijA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1
(Homo
sapiens) 		5 / 12 PHE A  70
LEU A  59
THR A  78
VAL A  47
VAL A  43
 None
 1.01A 2g78A-4uijA:
undetectable		 2g78A-4uijA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1
(Homo
sapiens) 		3 / 3 TYR A  99
GLU A 120
TYR A 123
 None
 1.01A 3ug8A-4uijA:
undetectable		 3ug8A-4uijA:
18.84