SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4uip REPEBODY (RAC1)
(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		5 / 12 LEU B 115
LEU B  91
ALA B  70
VAL B  57
LEU B  98
 None
 1.14A 1s9pD-4uipB:
undetectable		 1s9pD-4uipB:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4uip REPEBODY (RAC1)
(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		5 / 12 LEU B 163
LEU B 139
LEU B 115
LEU B 149
LEU B 146
 None
 1.05A 1sqnB-4uipB:
undetectable		 1sqnB-4uipB:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4uip REPEBODY (RAC1)
(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		4 / 6 LEU B  76
LEU B  82
PRO B 102
VAL B 105
 None
 1.14A 2dqyC-4uipB:
undetectable		 2dqyC-4uipB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4uip REPEBODY (RAC1)
(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		5 / 12 LEU B  71
LEU B  93
ILE B  23
LEU B 109
VAL B  66
 None
 1.23A 2hrcB-4uipB:
undetectable		 2hrcB-4uipB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4uip REPEBODY (RAC1)
(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		5 / 12 LEU B  98
LEU B 122
LEU B 146
ILE B  79
LEU B 163
 None
 1.12A 2pnjA-4uipB:
undetectable		 2pnjA-4uipB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4uip REPEBODY (RAC1)
(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		4 / 7 ILE B 208
TYR B 203
PHE B 178
ASP B 179
 None
 1.15A 2qebB-4uipB:
undetectable		 2qebB-4uipB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4uip REPEBODY (RAC1)
(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		4 / 4 ASN B  74
VAL B  57
THR B  22
ILE B  23
 None
 1.38A 4retA-4uipB:
undetectable		 4retA-4uipB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4uip REPEBODY (RAC1)
(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		4 / 4 ASN B  74
VAL B  57
THR B  22
ILE B  23
 None
 1.38A 4retC-4uipB:
undetectable		 4retC-4uipB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4uip REPEBODY (RAC1)
(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		4 / 5 PHE B  19
ILE B  44
GLY B  59
ILE B  47
 None
 0.85A 5dzkB-4uipB:
1.8
5dzkI-4uipB:
undetectable
5dzkW-4uipB:
undetectable		 5dzkB-4uipB:
21.84
5dzkI-4uipB:
21.24
5dzkW-4uipB:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4uip REPEBODY (RAC1)
(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		5 / 12 ASP B 140
GLY B  73
SER B 118
GLU B 119
TYR B  95
 None
 1.31A 5hfjA-4uipB:
undetectable		 5hfjA-4uipB:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4uip REPEBODY (RAC1)
(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		5 / 12 ASP B 140
GLY B  73
SER B 118
GLU B 119
TYR B  95
 None
 1.33A 5hfjC-4uipB:
undetectable		 5hfjC-4uipB:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4uip REPEBODY (RAC1)
(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		5 / 12 LEU B  27
LEU B  63
PRO B  64
PHE B  14
THR B   8
 None
 1.24A 6debB-4uipB:
undetectable		 6debB-4uipB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4uip REPEBODY (RAC1)
(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		5 / 12 ASP B  78
LEU B 133
ASP B 107
LEU B 112
LEU B  93
 None
 1.06A 6ew0F-4uipB:
undetectable		 6ew0F-4uipB:
16.94