SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uiq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		3 / 3 VAL A  76
VAL A  89
TRP A  72
 None
None
HEM  A 200 (-3.2A)
 0.89A 1av2C-4uiqA:
undetectable
1av2D-4uiqA:
undetectable		 1av2C-4uiqA:
15.69
1av2D-4uiqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		3 / 3 TRP A  24
ALA A  27
VAL A  25
 None
 0.94A 1bdwA-4uiqA:
undetectable
1bdwB-4uiqA:
undetectable		 1bdwA-4uiqA:
15.69
1bdwB-4uiqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		3 / 3 VAL A  76
VAL A  89
TRP A  72
 None
None
HEM  A 200 (-3.2A)
 0.80A 1w5uC-4uiqA:
undetectable
1w5uD-4uiqA:
undetectable		 1w5uC-4uiqA:
15.69
1w5uD-4uiqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		3 / 3 VAL A  89
TRP A  72
VAL A  76
 None
HEM  A 200 (-3.2A)
None
 0.81A 2izqA-4uiqA:
undetectable
2izqB-4uiqA:
undetectable		 2izqA-4uiqA:
15.69
2izqB-4uiqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		3 / 3 VAL A  76
VAL A  89
TRP A  72
 None
None
HEM  A 200 (-3.2A)
 0.70A 3l8lC-4uiqA:
undetectable
3l8lD-4uiqA:
undetectable		 3l8lC-4uiqA:
15.69
3l8lD-4uiqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		4 / 5 VAL A 145
ILE A 117
MET A  46
ARG A  28
 None
None
HEM  A 200 (-3.3A)
None
 1.32A 3pyyB-4uiqA:
undetectable		 3pyyB-4uiqA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		3 / 3 GLN A  70
GLU A  74
LYS A  35
 None
 1.19A 3su9A-4uiqA:
undetectable		 3su9A-4uiqA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY
(Bordetella
pertussis) 		4 / 6 SER A  75
GLU A  74
VAL A 145
THR A 146
 None
 1.18A 4lnxA-4uiqA:
undetectable		 4lnxA-4uiqA:
20.53