SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 GLN A  97
GLY A  69
GLU A  96
LEU A  98
THR A 329
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.4A)
FAD  A 701 (-3.6A)
FAD  A 701 (-4.3A)
FAD  A 701 (-4.4A)
 1.08A 1jg2A-4uirA:
4.0		 1jg2A-4uirA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 11 GLN A  97
GLY A  69
GLU A  96
LEU A  98
THR A 329
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.4A)
FAD  A 701 (-3.6A)
FAD  A 701 (-4.3A)
FAD  A 701 (-4.4A)
 1.07A 1jg3A-4uirA:
2.7		 1jg3A-4uirA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 11 GLN A  97
GLY A  69
GLU A  96
LEU A  98
THR A 329
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.4A)
FAD  A 701 (-3.6A)
FAD  A 701 (-4.3A)
FAD  A 701 (-4.4A)
 1.09A 1jg3B-4uirA:
3.7		 1jg3B-4uirA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 6 GLU A 141
ILE A 117
TYR A 115
GLY A 109
 None
 0.89A 1maaB-4uirA:
undetectable
1maaD-4uirA:
undetectable		 1maaB-4uirA:
20.72
1maaD-4uirA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 10 VAL A 536
LEU A 564
GLY A 534
LEU A 535
ILE A  67
 None
 1.49A 1sq5D-4uirA:
undetectable		 1sq5D-4uirA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 7 LEU A 591
ILE A 191
ASP A 186
PHE A 210
 None
 0.81A 1uwjA-4uirA:
undetectable		 1uwjA-4uirA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 ILE A 137
ALA A  78
ALA A 557
ARG A 555
GLU A 551
 None
 1.18A 2j0dA-4uirA:
undetectable		 2j0dA-4uirA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 ILE A  67
ILE A 327
ILE A  82
PHE A  94
VAL A 270
 None
 1.06A 2ygnA-4uirA:
undetectable		 2ygnA-4uirA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 GLY A 109
TYR A 152
ILE A 116
GLY A 120
GLY A 107
 None
None
None
P6G  A1649 ( 3.3A)
None
 1.02A 3hs6B-4uirA:
undetectable		 3hs6B-4uirA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 ASN A 575
GLU A 551
ARG A 524
VAL A 525
ILE A 559
 None
 1.45A 3jayA-4uirA:
undetectable		 3jayA-4uirA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 ASN A 575
GLU A 551
ARG A 524
VAL A 525
ILE A 559
 None
 1.40A 3jb2A-4uirA:
undetectable		 3jb2A-4uirA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 ASN A 575
GLU A 551
ARG A 524
VAL A 525
ILE A 559
 None
 1.26A 3jb3A-4uirA:
2.9		 3jb3A-4uirA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 4 GLY A 251
ASP A 254
GLY A 422
THR A 225
 NA  A1648 ( 4.6A)
NA  A1648 ( 3.8A)
None
None
 1.08A 3k4vC-4uirA:
undetectable		 3k4vC-4uirA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 7 LEU A 493
SER A 399
THR A 500
VAL A 502
 None
 0.92A 3ozkB-4uirA:
undetectable		 3ozkB-4uirA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 7 ASP A  26
PRO A  25
GLN A 570
GLU A  24
 None
 1.16A 3s3oA-4uirA:
undetectable		 3s3oA-4uirA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		3 / 3 LEU A 246
HIS A 243
MET A 242
 None
 0.95A 3thrD-4uirA:
undetectable		 3thrD-4uirA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 6 THR A 271
GLY A 102
ASP A 101
ILE A 284
 None
 0.83A 3w9tF-4uirA:
undetectable		 3w9tF-4uirA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 7 THR A 268
HIS A 442
ASN A 438
TYR A 152
 None
None
P6G  A1649 (-3.4A)
None
 1.30A 4a3uA-4uirA:
undetectable		 4a3uA-4uirA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 7 THR A 268
HIS A 442
ASN A 438
TYR A 152
 None
None
P6G  A1649 (-3.4A)
None
 1.29A 4a3uB-4uirA:
undetectable		 4a3uB-4uirA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 11 ASN A 264
GLY A 119
SER A 391
GLY A 114
ASN A 341
 None
FAD  A 701 (-3.3A)
None
None
None
 1.43A 4a99D-4uirA:
12.0		 4a99D-4uirA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 LEU A 277
GLY A  71
SER A 104
ARG A 118
ILE A  72
 None
FAD  A 701 (-3.6A)
FAD  A 701 (-2.3A)
None
FAD  A 701 (-4.8A)
 1.48A 4djeA-4uirA:
undetectable		 4djeA-4uirA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 GLN A 492
ALA A 400
LEU A 401
LEU A 483
ILE A 168
 None
 0.86A 4g1bA-4uirA:
5.6		 4g1bA-4uirA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 8 ILE A  65
LYS A  64
ILE A  92
ALA A  89
 None
 0.93A 4ou1A-4uirA:
undetectable		 4ou1A-4uirA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 SER A 160
ASP A 254
GLY A 251
ASP A 250
ASP A 124
 None
NA  A1648 ( 3.8A)
NA  A1648 ( 4.6A)
None
P6G  A1649 ( 4.2A)
 1.06A 4pghB-4uirA:
2.5		 4pghB-4uirA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		3 / 3 ILE A  72
ASP A 101
ARG A 121
 FAD  A 701 (-4.8A)
None
FAD  A 701 (-4.1A)
 0.84A 4pstA-4uirA:
undetectable		 4pstA-4uirA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 8 ALA A 560
ILE A  72
GLY A 537
THR A 330
 None
FAD  A 701 (-4.8A)
FAD  A 701 (-3.5A)
None
 0.61A 4r20A-4uirA:
undetectable		 4r20A-4uirA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 6 LYS A 262
PRO A 261
LEU A 140
GLU A 141
 None
 1.36A 4z4cA-4uirA:
2.4		 4z4cA-4uirA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 ILE A 489
GLU A 490
CYH A 396
THR A 500
LEU A 480
 None
 1.46A 5fhzD-4uirA:
2.3		 5fhzD-4uirA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		3 / 3 VAL A 571
LEU A 273
MET A  75
 None
 0.90A 5ikrA-4uirA:
undetectable		 5ikrA-4uirA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 10 VAL A 502
GLY A 114
LEU A 401
LEU A 453
THR A 393
 None
 0.97A 5vm8B-4uirA:
undetectable		 5vm8B-4uirA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 VAL A 554
ALA A 144
LEU A 273
PHE A 134
LEU A 130
 None
 1.28A 6a7pB-4uirA:
undetectable		 6a7pB-4uirA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 8 ASP A 580
ILE A 581
ARG A 582
TYR A 611
 None
 1.17A 6hisA-4uirA:
undetectable
6hisB-4uirA:
undetectable		 6hisA-4uirA:
8.52
6hisB-4uirA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 8 ASP A 580
ILE A 581
ARG A 582
TYR A 611
 None
 1.16A 6hisB-4uirA:
undetectable
6hisC-4uirA:
undetectable		 6hisB-4uirA:
8.52
6hisC-4uirA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 8 ASP A 580
ILE A 581
ARG A 582
TYR A 611
 None
 1.15A 6hisC-4uirA:
undetectable
6hisD-4uirA:
undetectable		 6hisC-4uirA:
8.52
6hisD-4uirA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 8 ASP A 580
ILE A 581
ARG A 582
TYR A 611
 None
 1.16A 6hisD-4uirA:
undetectable
6hisE-4uirA:
undetectable		 6hisD-4uirA:
8.52
6hisE-4uirA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 8 TYR A 611
ASP A 580
ILE A 581
ARG A 582
 None
 1.15A 6hisA-4uirA:
undetectable
6hisE-4uirA:
undetectable		 6hisA-4uirA:
8.52
6hisE-4uirA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		5 / 12 LEU A 193
ILE A 206
TYR A 209
LEU A 215
ASP A 186
 None
 1.12A 6ie8A-4uirA:
undetectable		 6ie8A-4uirA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4uir OLEATE HYDRATASE
(Elizabethkingia
meningoseptica) 		4 / 7 ASP A 136
ARG A  83
TYR A  79
ASP A  84
 None
 1.18A 6mn5E-4uirA:
undetectable		 6mn5E-4uirA:
9.34