SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.13A 1l5qB-4uisA:
2.9		 1l5qB-4uisA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 4 THR A 483
LEU A 487
VAL A 490
LEU A 494
 None
 0.74A 1mz9D-4uisA:
undetectable		 1mz9D-4uisA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		5 / 12 PHE A 287
LEU A 125
PRO A 136
LEU A 171
PHE A 103
 None
 1.09A 1og5A-4uisA:
undetectable		 1og5A-4uisA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.13A 3dd1A-4uisA:
2.6		 3dd1A-4uisA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.12A 3ddsA-4uisA:
undetectable		 3ddsA-4uisA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.14A 3ddsB-4uisA:
undetectable		 3ddsB-4uisA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.12A 3ddwA-4uisA:
undetectable		 3ddwA-4uisA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.15A 3ddwB-4uisA:
undetectable		 3ddwB-4uisA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		3 / 3 ASN A 290
TRP A 289
ASP A 548
 None
 0.91A 4a7tA-4uisA:
undetectable
4a7tF-4uisA:
undetectable		 4a7tA-4uisA:
13.63
4a7tF-4uisA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		5 / 11 GLN B 454
THR B 449
ASN B 405
VAL B  97
ILE B 408
 None
 1.32A 4claA-4uisB:
undetectable		 4claA-4uisB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		5 / 9 ALA A 369
LEU A 365
LEU A 487
LEU A 522
VAL A 518
 None
 1.17A 4or0B-4uisA:
undetectable		 4or0B-4uisA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		5 / 12 ILE B 229
TYR B 181
VAL B 185
LEU B 232
LEU B 201
 None
 1.06A 4qynA-4uisB:
undetectable		 4qynA-4uisB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		5 / 12 ILE B 229
TYR B 181
VAL B 185
LEU B 232
LEU B 201
 None
 1.14A 4qzuC-4uisB:
undetectable		 4qzuC-4uisB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_A_ASCA502_0
(OS09G0567300 PROTEIN)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 5 GLU A 333
PRO A 424
ARG A 281
PHE A 448
 None
 1.46A 5jcnA-4uisA:
undetectable		 5jcnA-4uisA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		4 / 6 GLU A 333
PRO A 424
ARG A 281
PHE A 448
 None
 1.46A 5jcnB-4uisA:
undetectable		 5jcnB-4uisA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4uis GAMMA-SECRETASE
(Homo
sapiens) 		3 / 3 GLU A 474
LEU A 477
ARG A 520
 None
 0.61A 6d8fA-4uisA:
undetectable		 6d8fA-4uisA:
20.37