SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 LYS A 152
LEU A 156
ALA A 144
LEU A 141
 None
 1.47A 1f86B-4uj6A:
undetectable		 1f86B-4uj6A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 PRO A 372
ASP A 443
ASP A 491
 None
 0.81A 1sqfA-4uj6A:
undetectable		 1sqfA-4uj6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 128
ARG A 138
GLN A 139
 None
 1.00A 1tw4A-4uj6A:
undetectable		 1tw4A-4uj6A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 471
GLN A 582
LEU A 516
PRO A 526
VAL A 524
 None
 1.26A 2qd4A-4uj6A:
undetectable		 2qd4A-4uj6A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 471
GLN A 582
LEU A 516
PRO A 526
VAL A 524
 None
 1.14A 2qd4B-4uj6A:
undetectable		 2qd4B-4uj6A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 165
ARG A 195
LYS A 207
 None
 1.45A 3okxA-4uj6A:
undetectable		 3okxA-4uj6A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 350
PHE A 275
VAL A 334
PHE A 279
ALA A 318
 None
 1.26A 3u9fG-4uj6A:
undetectable
3u9fH-4uj6A:
undetectable		 3u9fG-4uj6A:
12.90
3u9fH-4uj6A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 ASN A  81
ALA A  84
LEU A  98
LEU A 101
 None
 0.93A 4ejgC-4uj6A:
undetectable		 4ejgC-4uj6A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 110
THR A 123
ILE A 125
ASP A 126
 None
 1.03A 4pcuA-4uj6A:
undetectable		 4pcuA-4uj6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 THR A 336
LEU A 339
ILE A 289
THR A 287
 None
 0.98A 5zsfA-4uj6A:
undetectable
5zsfB-4uj6A:
undetectable		 5zsfA-4uj6A:
8.01
5zsfB-4uj6A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A 288
VAL A 277
ALA A 318
VAL A 264
GLY A 315
 None
 1.26A 6bklA-4uj6A:
undetectable
6bklB-4uj6A:
undetectable
6bklC-4uj6A:
undetectable
6bklD-4uj6A:
undetectable		 6bklA-4uj6A:
2.52
6bklB-4uj6A:
2.52
6bklC-4uj6A:
2.52
6bklD-4uj6A:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 120
GLY A 117
GLU A 118
 None
 0.62A 6fgdA-4uj6A:
undetectable		 6fgdA-4uj6A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 ALA A 211
ALA A 214
ALA A 223
ALA A 226
 None
 0.81A 6gtqA-4uj6A:
undetectable
6gtqB-4uj6A:
undetectable		 6gtqA-4uj6A:
10.95
6gtqB-4uj6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4uj6 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 ALA A 223
ALA A 226
ALA A 211
ALA A 214
 None
 0.81A 6gtqA-4uj6A:
undetectable
6gtqB-4uj6A:
undetectable		 6gtqA-4uj6A:
10.95
6gtqB-4uj6A:
10.95