SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ukd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 12 ILE A  55
GLY A  62
VAL A  65
SER A 144
GLY A  38
 None
UDP  A 196 ( 4.1A)
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
 1.10A 1nbhB-4ukdA:
undetectable		 1nbhB-4ukdA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 12 ILE A  55
GLY A  62
VAL A  65
SER A 144
GLY A  38
 None
UDP  A 196 ( 4.1A)
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
 1.05A 1nbiA-4ukdA:
undetectable		 1nbiA-4ukdA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 12 ILE A  55
GLY A  62
VAL A  65
SER A 144
GLY A  38
 None
UDP  A 196 ( 4.1A)
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
 1.07A 1nbiB-4ukdA:
undetectable		 1nbiB-4ukdA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		4 / 5 GLY A  20
GLN A  22
VAL A  11
SER A  17
 ADP  A 195 (-3.7A)
None
None
ADP  A 195 (-3.7A)
 1.16A 1p6kB-4ukdA:
undetectable		 1p6kB-4ukdA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		4 / 5 GLY A  20
GLN A  22
VAL A  11
SER A  17
 ADP  A 195 (-3.7A)
None
None
ADP  A 195 (-3.7A)
 1.15A 1rs6B-4ukdA:
undetectable		 1rs6B-4ukdA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		3 / 3 SER A  17
GLY A  16
ARG A  93
 ADP  A 195 (-3.7A)
ADP  A 195 ( 3.4A)
UDP  A 196 (-2.9A)
 0.63A 1t9wA-4ukdA:
undetectable		 1t9wA-4ukdA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		4 / 5 GLY A  20
GLN A  22
VAL A  11
SER A  17
 ADP  A 195 (-3.7A)
None
None
ADP  A 195 (-3.7A)
 1.18A 1zzuB-4ukdA:
undetectable		 1zzuB-4ukdA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		4 / 8 ALA A  77
ILE A  78
ASN A  81
PRO A   6
 None
 0.87A 3fxrA-4ukdA:
undetectable		 3fxrA-4ukdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 10 ASP A  39
SER A  36
GLY A  20
ARG A 131
ASP A 139
 None
MG  A 500 ( 4.5A)
ADP  A 195 (-3.7A)
BF2  A 501 ( 2.6A)
UDP  A 196 ( 4.6A)
 1.25A 3n2oC-4ukdA:
undetectable
3n2oD-4ukdA:
undetectable		 3n2oC-4ukdA:
14.88
3n2oD-4ukdA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 11 ASP A 184
ARG A 176
PHE A 117
ILE A  26
ARG A  28
 None
 1.35A 3vawA-4ukdA:
undetectable		 3vawA-4ukdA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		4 / 8 ARG A 131
ARG A 148
ASP A  89
ARG A  93
 BF2  A 501 ( 2.6A)
BF2  A 501 ( 3.6A)
MG  A 500 ( 4.1A)
UDP  A 196 (-2.9A)
 1.34A 4kr4C-4ukdA:
undetectable		 4kr4C-4ukdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 12 VAL A  65
SER A  36
GLY A  38
ASP A  89
LYS A  19
 UDP  A 196 (-3.7A)
MG  A 500 ( 4.5A)
UDP  A 196 (-3.6A)
MG  A 500 ( 4.1A)
ADP  A 195 ( 2.7A)
 1.49A 4pevC-4ukdA:
undetectable		 4pevC-4ukdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 9 VAL A  71
VAL A  65
LEU A  74
GLY A  38
LEU A  40
 None
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
None
 1.14A 6czmA-4ukdA:
undetectable
6czmB-4ukdA:
undetectable		 6czmA-4ukdA:
20.44
6czmB-4ukdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 9 VAL A  71
VAL A  65
LEU A  74
GLY A  38
LEU A  40
 None
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
None
 1.13A 6czmB-4ukdA:
undetectable
6czmC-4ukdA:
undetectable		 6czmB-4ukdA:
20.44
6czmC-4ukdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE
(Dictyostelium
discoideum) 		5 / 9 VAL A  71
VAL A  65
LEU A  74
GLY A  38
LEU A  40
 None
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
None
 1.11A 6czmD-4ukdA:
undetectable
6czmE-4ukdA:
undetectable		 6czmD-4ukdA:
20.44
6czmE-4ukdA:
20.44