SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ulx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1498_1 (CYTOCHROME P450 3A4)	4ulx	LPBCA-L89K THIOREDOXIN (synthetic construct)	5 / 12	PHE A 11 LEU A 44 LEU A 23 ILE A 37 ALA A 38	None None None None CL A1107 (-3.6A)	1.27A	2v0mC-4ulxA: undetectable	2v0mC-4ulxA: 13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_B_PM6B301_1 (THIOPURINE S-METHYLTRANSFERASE)	4ulx	LPBCA-L89K THIOREDOXIN (synthetic construct)	4 / 8	PHE A 80 VAL A 52 LEU A 106 PRO A 21	None	0.99A	3bgdB-4ulxA: undetectable	3bgdB-4ulxA: 19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_B_CHDB503_0 (FERROCHELATASE, MITOCHONDRIAL)	4ulx	LPBCA-L89K THIOREDOXIN (synthetic construct)	4 / 8	PRO A 94 LYS A 89 VAL A 90 GLY A 91	None	0.82A	4klrB-4ulxA: 3.1	4klrB-4ulxA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLA_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	4ulx	LPBCA-L89K THIOREDOXIN (synthetic construct)	4 / 5	LYS A 99 LEU A 44 GLU A 47 TYR A 48	None	1.20A	4olaA-4ulxA: undetectable	4olaA-4ulxA: 8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JS1_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	4ulx	LPBCA-L89K THIOREDOXIN (synthetic construct)	4 / 5	LYS A 99 LEU A 44 GLU A 47 TYR A 48	None	1.25A	5js1A-4ulxA: undetectable	5js1A-4ulxA: 8.85

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V0M_C_KLNC1498_1","CYTOCHROME P450 3A4","4ulx","LPBCA-L89K THIOREDOXIN","synthetic construct",5,"PHE A  11;LEU A  44;LEU A  23;ILE A  37;ALA A  38","None;None;None;None; CL A1107 (-3.6A)","1.27A","2v0mC-4ulxA:undetectable","2v0mC-4ulxA:13.20"],["3BGD_B_PM6B301_1","THIOPURINE S-METHYLTRANSFERASE","4ulx","LPBCA-L89K THIOREDOXIN","synthetic construct",4,"PHE A  80;VAL A  52;LEU A 106;PRO A  21","None","0.99A","3bgdB-4ulxA:undetectable","3bgdB-4ulxA:19.92"],["4KLR_B_CHDB503_0","FERROCHELATASE, MITOCHONDRIAL","4ulx","LPBCA-L89K THIOREDOXIN","synthetic construct",4,"PRO A  94;LYS A  89;VAL A  90;GLY A  91","None","0.82A","4klrB-4ulxA:3.1","4klrB-4ulxA:14.44"],["4OLA_A_IPHA901_0","PROTEIN ARGONAUTE-2","4ulx","LPBCA-L89K THIOREDOXIN","synthetic construct",4,"LYS A  99;LEU A  44;GLU A  47;TYR A  48","None","1.20A","4olaA-4ulxA:undetectable","4olaA-4ulxA:8.85"],["5JS1_A_IPHA901_0","PROTEIN ARGONAUTE-2","4ulx","LPBCA-L89K THIOREDOXIN","synthetic construct",4,"LYS A  99;LEU A  44;GLU A  47;TYR A  48","None","1.25A","5js1A-4ulxA:undetectable","5js1A-4ulxA:8.85"]]