SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4um2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 5 GLU A 680
LEU A 674
LEU A 677
LEU A 675
 None
 1.00A 1np1A-4um2A:
undetectable		 1np1A-4um2A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 4 ASP A 679
LEU A 674
LEU A 677
LEU A 675
 None
 1.38A 1u18A-4um2A:
undetectable		 1u18A-4um2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		5 / 9 TYR A 738
GLY A 733
ALA A 751
ASP A 734
TYR A 778
 None
 1.32A 2uy4A-4um2A:
undetectable		 2uy4A-4um2A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 8 LEU A 595
LEU A 599
LEU A 609
PHE A 655
 None
 0.76A 2vcvP-4um2A:
3.6		 2vcvP-4um2A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 7 LEU A 903
ALA A 972
GLY A 975
PHE A 810
 None
 0.91A 2wq5A-4um2A:
2.0		 2wq5A-4um2A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		5 / 10 TYR A 738
GLY A 733
ALA A 751
ASP A 734
TYR A 778
 None
 1.24A 2xtkB-4um2A:
undetectable		 2xtkB-4um2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		3 / 3 MET A 939
VAL A1026
GLU A1021
 None
 0.91A 3c6gA-4um2A:
undetectable		 3c6gA-4um2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 7 ASN A1041
PRO A1043
TRP A1040
PHE A1134
 None
 1.08A 4v32A-4um2A:
undetectable		 4v32A-4um2A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 7 ASN A1041
PRO A1043
TRP A1040
PHE A1134
 None
 1.11A 4v32B-4um2A:
undetectable		 4v32B-4um2A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 6 ARG A 727
CYH A 728
ILE A 730
GLN A 726
 None
 1.02A 4w5qA-4um2A:
undetectable		 4w5qA-4um2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		5 / 12 TYR A 787
GLY A 766
PHE A 948
LEU A 783
ALA A 776
 None
 1.20A 4wcxC-4um2A:
4.2		 4wcxC-4um2A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 6 ARG A 727
CYH A 728
ILE A 730
GLN A 726
 None
 0.99A 4z4cA-4um2A:
undetectable		 4z4cA-4um2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 7 ARG A 727
CYH A 728
ILE A 730
GLN A 726
 None
 1.03A 4z4gA-4um2A:
undetectable		 4z4gA-4um2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 7 LEU A 920
VAL A 915
ASN A 946
ILE A 945
 None
 1.07A 5jh7C-4um2A:
undetectable		 5jh7C-4um2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 7 PHE A 923
PHE A 912
MET A 943
LEU A 974
 None
 1.21A 6aycA-4um2A:
2.2		 6aycA-4um2A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 6 ARG A 727
CYH A 728
ILE A 730
GLN A 726
 None
 1.03A 6cbdA-4um2A:
undetectable		 6cbdA-4um2A:
20.88