SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4um8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		3 / 3 PHE B 311
LEU B 320
SER B 257
 None
 0.67A 1e7aA-4um8B:
undetectable		 1e7aA-4um8B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		4 / 6 LEU B 423
LEU B 360
LEU B 429
LEU B  92
 None
 0.90A 1errA-4um8B:
undetectable		 1errA-4um8B:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 VAL B 250
ILE B 343
ASN B 207
SER B 143
LEU B 118
 None
 1.24A 1fm4A-4um8B:
undetectable		 1fm4A-4um8B:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ILE A 433
GLY A 405
PHE A 404
VAL A  23
ALA A  22
 None
 1.14A 1tlsB-4um8A:
undetectable		 1tlsB-4um8A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ILE A 191
ALA A 140
PHE A 129
GLN A 131
TYR A 204
 None
 1.45A 1u70A-4um8A:
undetectable		 1u70A-4um8A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		3 / 3 LEU A 538
PHE A 513
ARG A 588
 None
 0.78A 1xdkF-4um8A:
undetectable		 1xdkF-4um8A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
 None
 1.17A 1xmuA-4um8A:
undetectable		 1xmuA-4um8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
 None
 1.16A 1xmuB-4um8A:
undetectable		 1xmuB-4um8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
 None
 1.20A 1xoqA-4um8A:
undetectable		 1xoqA-4um8A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
 None
 1.18A 1xoqB-4um8A:
undetectable		 1xoqB-4um8A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 7 VAL A 226
SER A 241
LEU A 171
THR A 210
 None
 1.02A 2f78A-4um8A:
undetectable		 2f78A-4um8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 7 VAL A 226
SER A 241
LEU A 171
THR A 210
 None
 1.07A 2f78B-4um8A:
undetectable		 2f78B-4um8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLU B 291
TYR A 275
PHE A 278
GLY B 260
 None
 1.11A 2ha4A-4um8B:
2.2		 2ha4A-4um8B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens) 		5 / 10 THR A 249
THR B 221
ALA B 255
SER B 253
PHE B 251
 None
None
MG  B2001 ( 4.2A)
MG  B2001 ( 4.2A)
None
 1.26A 2ij7D-4um8A:
undetectable		 2ij7D-4um8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 9 GLY A 418
THR A 582
VAL A 440
PRO A 439
ILE A 441
 SO4  A1598 (-3.7A)
None
None
None
None
 1.32A 2nnhB-4um8A:
undetectable		 2nnhB-4um8A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		3 / 3 PRO B  45
ASN B  60
ARG B  97
 None
 0.95A 2qeuB-4um8B:
undetectable		 2qeuB-4um8B:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		4 / 7 GLY B 224
PHE B 251
ILE B 229
PHE B 311
 None
 0.92A 2qmzA-4um8B:
3.2
2qmzB-4um8B:
3.9		 2qmzA-4um8B:
14.87
2qmzB-4um8B:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 PHE B 157
TYR B 120
LEU B 249
SER B 127
SER B 125
 None
None
None
MG  B2001 (-3.7A)
MG  B2001 (-2.1A)
 1.28A 2vdmA-4um8B:
undetectable
2vdmB-4um8B:
34.6		 2vdmA-4um8B:
19.97
2vdmB-4um8B:
43.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		4 / 4 TYR B 119
LEU B 155
LEU B 199
HIS B 195
 None
 1.34A 2x7hB-4um8B:
undetectable		 2x7hB-4um8B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 11 VAL A 424
GLY A 425
VAL A  23
ILE A 360
ALA A 361
 None
 1.05A 2yy8A-4um8A:
undetectable
2yy8B-4um8A:
undetectable		 2yy8A-4um8A:
16.33
2yy8B-4um8A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 10 THR A 127
ASN A  77
GLU A  87
GLY A  53
GLN A  92
 None
CL  A1595 (-3.7A)
None
None
None
 1.21A 2z71A-4um8A:
0.0
2z71C-4um8A:
0.0		 2z71A-4um8A:
20.95
2z71C-4um8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 PHE A 427
GLU B 291
ARG A 339
ALA A 343
SER A 279
 None
None
SO4  A1597 ( 4.8A)
None
None
 1.44A 3apvA-4um8A:
undetectable		 3apvA-4um8A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 4 SER A 241
GLY A 242
GLY A 172
GLY A 181
 None
 0.88A 3bogB-4um8A:
undetectable
3bogD-4um8A:
undetectable		 3bogB-4um8A:
undetectable
3bogD-4um8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 6 ALA A 540
LEU A 542
SER A 471
VAL A 475
 None
 0.97A 3d2tB-4um8A:
undetectable		 3d2tB-4um8A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 PHE A 278
VAL A 312
GLY A 313
GLY A 341
ALA A 338
 None
 1.31A 3dh0A-4um8A:
undetectable		 3dh0A-4um8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 ILE B 418
VAL B 362
GLU B 359
LEU B 423
VAL B 106
 None
 1.21A 3fpjB-4um8B:
undetectable		 3fpjB-4um8B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 LEU A  57
ALA A 432
GLY A 428
PRO A  41
VAL A  38
 None
 1.03A 3gguA-4um8A:
undetectable		 3gguA-4um8A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 THR A 329
ASP A 292
ILE A 358
LEU A 383
ARG A 379
 None
CA  A2002 (-2.1A)
None
None
None
 1.32A 3iv6B-4um8A:
undetectable		 3iv6B-4um8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 11 ALA A 437
ASN A 356
VAL A 440
ASN A 377
PHE A   1
 CA  A2004 ( 4.4A)
None
None
None
None
 1.22A 3jw5A-4um8A:
undetectable		 3jw5A-4um8A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 296
ASN B 305
GLY B 274
ASN B 272
ARG A 339
 None
None
None
None
SO4  A1597 ( 4.8A)
 1.21A 3k13B-4um8B:
undetectable		 3k13B-4um8B:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 11 GLY A 158
SER A  97
LEU A 106
LEU A 170
LEU A 171
 None
 1.26A 3ndvA-4um8A:
undetectable
3ndvB-4um8A:
undetectable		 3ndvA-4um8A:
23.03
3ndvB-4um8A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 11 LEU A 170
LEU A 171
GLY A 158
SER A  97
LEU A 106
 None
 1.20A 3ndvA-4um8A:
undetectable
3ndvB-4um8A:
undetectable		 3ndvA-4um8A:
23.03
3ndvB-4um8A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 11 GLY A 158
SER A  97
LEU A 106
LEU A 170
LEU A 171
 None
 1.22A 3ndvC-4um8A:
undetectable
3ndvD-4um8A:
undetectable		 3ndvC-4um8A:
23.03
3ndvD-4um8A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 11 LEU A 170
LEU A 171
GLY A 158
SER A  97
LEU A 106
 None
 1.26A 3ndvC-4um8A:
undetectable
3ndvD-4um8A:
undetectable		 3ndvC-4um8A:
23.03
3ndvD-4um8A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens) 		6 / 12 GLY A 157
GLY A 175
SER A 176
LEU B 265
ALA A 109
HIS A 113
 None
 1.46A 3ou6B-4um8A:
undetectable		 3ou6B-4um8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens) 		6 / 12 GLY A 157
GLY A 175
SER A 176
LEU B 265
ALA A 109
HIS A 113
 None
 1.45A 3ou7B-4um8A:
undetectable		 3ou7B-4um8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		3 / 3 TYR A 450
LEU A 502
ARG A 588
 None
 0.78A 3sufB-4um8A:
undetectable		 3sufB-4um8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ILE A 285
GLY A 378
THR A 283
GLY A 354
ASP A 353
 None
None
None
None
CA  A2003 (-2.9A)
 0.97A 3uboA-4um8A:
undetectable		 3uboA-4um8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 ALA B 266
TYR B 284
ASP B 227
GLY B 267
ILE B 268
 None
 1.28A 3vwqA-4um8B:
undetectable		 3vwqA-4um8B:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens) 		5 / 11 PHE B 259
GLY B 260
PRO A 244
ALA A 246
GLY A 251
 None
 1.30A 4a6nA-4um8B:
undetectable		 4a6nA-4um8B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens) 		5 / 7 ARG A 245
LEU B 265
GLY A 223
TYR A 224
SER A 225
 None
 1.27A 4cp3A-4um8A:
undetectable
4cp3B-4um8A:
undetectable		 4cp3A-4um8A:
10.66
4cp3B-4um8A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens) 		5 / 7 ARG A 245
LEU B 265
GLY A 242
TYR A 224
SER A 225
 None
 1.30A 4cp3A-4um8A:
undetectable
4cp3B-4um8A:
undetectable		 4cp3A-4um8A:
10.66
4cp3B-4um8A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 6 GLY A  54
PRO A  41
GLY A  20
TYR A  18
 None
 0.86A 4dxuA-4um8A:
undetectable		 4dxuA-4um8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		4 / 8 GLY B 224
PHE B 251
ILE B 229
PHE B 311
 None
 0.63A 4fglD-4um8B:
3.8		 4fglD-4um8B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ILE A 433
GLY A 405
PHE A 404
VAL A  23
ALA A  22
 None
 1.20A 4foxD-4um8A:
undetectable		 4foxD-4um8A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ILE A 433
GLY A 405
PHE A 404
VAL A  23
ALA A  22
 None
 1.23A 4fqsA-4um8A:
undetectable		 4fqsA-4um8A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ILE A 433
GLY A 405
PHE A 404
VAL A  23
ALA A  22
 None
 1.22A 4fqsB-4um8A:
undetectable		 4fqsB-4um8A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 LEU B 121
ALA B 331
ILE B 239
HIS B 195
LEU B 118
 None
 1.32A 4l9qA-4um8B:
undetectable		 4l9qA-4um8B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		3 / 3 SER A  29
ASP A 167
ASP A 237
 None
 0.86A 4mwzA-4um8A:
undetectable		 4mwzA-4um8A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN B 218
ASP B 220
ASP A 148
 None
 0.76A 4obwD-4um8B:
undetectable		 4obwD-4um8B:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 ILE B 295
ALA B 331
LEU B 298
LEU B 302
PHE B 311
 None
 1.27A 4pbhA-4um8B:
undetectable		 4pbhA-4um8B:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		4 / 6 GLY B 224
PHE B 251
ILE B 229
PHE B 311
 None
 0.73A 4qogA-4um8B:
3.8
4qogB-4um8B:
3.6		 4qogA-4um8B:
15.00
4qogB-4um8B:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ALA A  96
TYR A 406
PHE A 159
LEU A 111
TYR A 224
 None
 1.36A 4r7lA-4um8A:
undetectable		 4r7lA-4um8A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 LEU A  37
GLN A  55
ILE A 105
ALA A 107
PHE A  72
 None
 1.02A 4rp8C-4um8A:
undetectable		 4rp8C-4um8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 GLY A 175
GLY A 173
GLY A 223
SER A 176
ALA A 149
 None
 0.92A 4uciA-4um8A:
undetectable		 4uciA-4um8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 GLY A 175
GLY A 173
GLY A 223
SER A 176
ALA A 149
 None
 0.93A 4uciB-4um8A:
undetectable		 4uciB-4um8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 GLY A 175
GLY A 173
GLY A 223
SER A 176
ALA A 149
 None
 0.93A 4uckA-4um8A:
undetectable		 4uckA-4um8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		4 / 4 VAL B 106
ALA B  88
ASN B  70
GLN B  90
 None
 1.36A 4zgfA-4um8B:
undetectable		 4zgfA-4um8B:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 6 LEU A 170
ALA A 227
SER A 225
VAL A 293
 None
 1.19A 5a6iA-4um8A:
undetectable		 5a6iA-4um8A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 8 SER A 225
GLY A 242
ALA A 273
GLY A 251
 None
 0.83A 5albL-4um8A:
3.8		 5albL-4um8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 ALA A 246
GLY A 277
GLY A 251
GLY A 269
ARG A 245
 None
 0.77A 5c0oH-4um8A:
undetectable		 5c0oH-4um8A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		4 / 4 VAL B 318
GLU B 322
GLY B 334
LEU B 335
 None
 0.93A 5g5gC-4um8B:
undetectable		 5g5gC-4um8B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens) 		4 / 6 TYR B 292
ASP A 219
ILE B 219
TYR B 321
 None
 1.36A 5igyA-4um8B:
undetectable		 5igyA-4um8B:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 12 MET A 408
ILE A 433
LEU A 422
LEU A   3
PHE A 404
 None
 1.16A 5im2A-4um8A:
undetectable		 5im2A-4um8A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		3 / 3 GLY B 274
GLN B 231
LYS B 301
 None
 0.95A 5imsB-4um8B:
3.0		 5imsB-4um8B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		5 / 10 ALA A 359
VAL A 373
ILE A 433
VAL A  23
ALA A 345
 None
 1.00A 5nukA-4um8A:
undetectable		 5nukA-4um8A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 6 PHE A 239
LEU A 171
SER A 241
GLY A 223
 None
 1.09A 5o4yF-4um8A:
undetectable		 5o4yF-4um8A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 4 THR A 556
ASP A 500
ARG A 509
LEU A 502
 None
 1.14A 5tdmA-4um8A:
undetectable		 5tdmA-4um8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 6 THR A 556
ASP A 500
ARG A 509
LEU A 502
 None
 1.17A 5tdzA-4um8A:
undetectable		 5tdzA-4um8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 5 VAL A 243
PRO A 174
GLY A 181
TYR A 221
 None
 1.21A 5x80A-4um8A:
undetectable
5x80B-4um8A:
undetectable		 5x80A-4um8A:
12.04
5x80B-4um8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4um8 INTEGRIN BETA-6
(Homo
sapiens) 		3 / 3 TYR B 120
LEU B 155
ASP B 202
 None
 0.79A 5zv2B-4um8B:
undetectable		 5zv2B-4um8B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 7 ILE A 592
LEU A 454
ILE A 508
ALA A 540
 None
 0.84A 6b5vA-4um8A:
undetectable
6b5vC-4um8A:
undetectable		 6b5vA-4um8A:
9.71
6b5vC-4um8A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 7 ILE A 592
LEU A 454
ILE A 508
ALA A 540
 None
 0.85A 6b5vC-4um8A:
undetectable
6b5vD-4um8A:
undetectable		 6b5vC-4um8A:
9.71
6b5vD-4um8A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4um8 INTEGRIN ALPHA-V
(Homo
sapiens) 		4 / 7 ALA A 540
ILE A 592
LEU A 454
ILE A 508
 None
 0.83A 6b5vB-4um8A:
undetectable
6b5vD-4um8A:
undetectable		 6b5vB-4um8A:
9.71
6b5vD-4um8A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLN A 156
VAL A 125
PRO B 167
THR A 116
 None
 1.40A 6cduI-4um8A:
undetectable
6cduJ-4um8A:
2.5		 6cduI-4um8A:
18.84
6cduJ-4um8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 VAL B 165
TYR A 221
THR A 249
PRO A 298
GLY B 192
 None
 1.49A 6gngB-4um8B:
2.8		 6gngB-4um8B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 VAL B 169
TYR A 221
THR A 249
PRO A 298
GLY B 192
 None
 1.45A 6gngB-4um8B:
2.8		 6gngB-4um8B:
21.08