SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		5 / 12 HIS A 127
GLU A 111
LEU A 101
LEU A  79
GLY A 106
 None
 1.41A 1d4fD-4umlA:
undetectable		 1d4fD-4umlA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		4 / 6 ALA A 156
LEU A 155
ILE A 126
CYH A  68
 None
 1.06A 1sbrA-4umlA:
undetectable
1sbrB-4umlA:
undetectable		 1sbrA-4umlA:
20.17
1sbrB-4umlA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		4 / 4 THR A 188
VAL A 152
GLY A 110
THR A 109
 None
 1.05A 3cflA-4umlA:
undetectable		 3cflA-4umlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 155
ALA A  70
ILE A  89
GLY A 117
ILE A 126
 None
 1.06A 3cyxA-4umlA:
undetectable		 3cyxA-4umlA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		4 / 5 SER A 147
PRO A 131
TYR A 176
VAL A 129
 None
 1.39A 3sufC-4umlA:
undetectable		 3sufC-4umlA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 130
VAL A 129
HIS A 127
SER A  86
PRO A  84
 None
 1.33A 4bvaA-4umlA:
undetectable		 4bvaA-4umlA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		3 / 3 PHE A 223
VAL A  52
GLU A 194
 None
 0.78A 4fvqA-4umlA:
undetectable		 4fvqA-4umlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		5 / 12 HIS A 127
GLU A 111
LEU A 101
LEU A  79
GLY A 106
 None
 1.18A 4pgfB-4umlA:
2.1		 4pgfB-4umlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		5 / 12 TYR A 215
VAL A 152
LEU A 145
LEU A 186
LEU A 219
 None
 1.30A 4rtbA-4umlA:
undetectable		 4rtbA-4umlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		4 / 7 LEU A 210
GLU A 211
SER A 208
VAL A  85
 None
 1.13A 4tvtA-4umlA:
undetectable		 4tvtA-4umlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 168
ALA A 181
LEU A 193
LEU A 153
VAL A 152
 None
 1.17A 5tudA-4umlA:
undetectable		 5tudA-4umlA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2
(Homo
sapiens) 		3 / 3 GLY A 130
THR A 109
GLU A  77
 None
 0.46A 6b58A-4umlA:
undetectable		 6b58A-4umlA:
16.91