SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ums'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B
(Pseudobacteroide
s
cellulosolvens) 		6 / 12 ALA A1134
ILE A1061
PHE A1115
PHE A1103
LEU A1087
PHE A1138
 None
 1.12A 1dtlA-4umsA:
undetectable		 1dtlA-4umsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B
(Pseudobacteroide
s
cellulosolvens) 		3 / 3 SER A1124
ASP A1119
ASN A1118
 None
 0.88A 3lslA-4umsA:
undetectable
3lslD-4umsA:
undetectable		 3lslA-4umsA:
21.37
3lslD-4umsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B
(Pseudobacteroide
s
cellulosolvens) 		5 / 11 ILE A1179
ALA A1084
PHE A1138
ILE A1113
LEU A1151
 None
 1.19A 3qg2B-4umsA:
undetectable		 3qg2B-4umsA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B
(Pseudobacteroide
s
cellulosolvens) 		3 / 3 TRP A1041
MET A1042
ASN A1043
 None
 1.44A 5uc1A-4umsA:
undetectable		 5uc1A-4umsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B
(Pseudobacteroide
s
cellulosolvens) 		4 / 8 ILE A1061
PHE A1076
PRO A1099
PHE A1103
 None
 1.10A 5x23A-4umsA:
undetectable		 5x23A-4umsA:
17.86