SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4umz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 12 VAL A 368
LEU A 259
SER A 261
LEU A 380
TRP A 389
 None
 1.31A 1kw0A-4umzA:
undetectable		 1kw0A-4umzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 12 TYR A 286
VAL A 368
LEU A 259
SER A 261
LEU A 380
 None
 1.43A 1mmkA-4umzA:
undetectable		 1mmkA-4umzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 12 VAL A 368
LEU A 259
SER A 261
LEU A 380
TRP A 389
 None
 1.29A 1mmkA-4umzA:
undetectable		 1mmkA-4umzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 12 LEU A 130
ILE A 252
VAL A 249
HIS A 245
ALA A 400
 None
 1.15A 2g72B-4umzA:
undetectable		 2g72B-4umzA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		3 / 3 ALA A 243
THR A 247
CYH A 354
 HEM  A1407 (-3.6A)
HEM  A1407 (-3.8A)
HEM  A1407 (-2.1A)
 0.36A 3e4eA-4umzA:
32.1		 3e4eA-4umzA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		3 / 3 ALA A 243
THR A 247
CYH A 354
 HEM  A1407 (-3.6A)
HEM  A1407 (-3.8A)
HEM  A1407 (-2.1A)
 0.29A 3e4eB-4umzA:
31.8		 3e4eB-4umzA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 11 HIS A  42
VAL A  55
PHE A  70
LEU A 304
THR A 307
 None
 1.21A 3kwaA-4umzA:
undetectable		 3kwaA-4umzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 11 HIS A  42
VAL A  55
PHE A  70
LEU A 304
THR A 307
 None
 1.23A 3ml5A-4umzA:
undetectable		 3ml5A-4umzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 12 ALA A 253
LEU A 144
LEU A 378
ILE A 395
GLY A 288
 None
 1.11A 3ozwB-4umzA:
undetectable		 3ozwB-4umzA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		4 / 6 ARG A 296
HIS A 100
ARG A 104
ILE A 351
 HEM  A1407 (-3.1A)
HEM  A1407 (-3.8A)
HEM  A1407 (-3.8A)
None
 1.39A 5a06A-4umzA:
undetectable		 5a06A-4umzA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		4 / 5 ALA A 357
HIS A 344
ALA A 346
GLU A 281
 None
None
HEM  A1407 (-4.9A)
None
 1.43A 5a06C-4umzA:
undetectable
5a06D-4umzA:
undetectable		 5a06C-4umzA:
22.39
5a06D-4umzA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 10 LEU A 359
ALA A 360
GLU A 363
GLY A 288
LEU A 284
 HEM  A1407 ( 4.6A)
HEM  A1407 (-3.3A)
None
None
None
 1.33A 5dx3A-4umzA:
2.2		 5dx3A-4umzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		5 / 12 LEU A 359
ALA A 360
GLU A 363
GLY A 288
LEU A 284
 HEM  A1407 ( 4.6A)
HEM  A1407 (-3.3A)
None
None
None
 1.08A 5gtrA-4umzA:
2.4		 5gtrA-4umzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		4 / 8 ILE A 239
LEU A 240
LEU A 161
MET A  92
 HEM  A1407 ( 4.9A)
None
None
HEM  A1407 (-3.8A)
 1.08A 5u4sB-4umzA:
undetectable		 5u4sB-4umzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		4 / 7 LEU A  20
VAL A 318
GLU A 291
SER A 292
 None
 1.25A 5umwA-4umzA:
0.8
5umwF-4umzA:
0.8		 5umwA-4umzA:
14.29
5umwF-4umzA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		4 / 5 PHE A 178
THR A 189
ASP A 183
ASN A  50
 None
 1.40A 5ybbA-4umzA:
0.7		 5ybbA-4umzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 4umz CYTOCHROME P450
HYDROXYLASE PIKC
(Streptomyces
venezuelae) 		4 / 7 GLY A 397
ASP A 176
TRP A 150
TYR A 390
 None
 1.47A 6ag0C-4umzA:
undetectable		 6ag0C-4umzA:
11.17