SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4unf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		4 / 5 LEU A  85
VAL A 145
LEU A 139
ARG A  47
 None
MG  A1250 (-4.7A)
None
None
 1.11A 2oiqA-4unfA:
undetectable		 2oiqA-4unfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ALA A 117
LEU A 124
LEU A  53
THR A 111
LEU A 112
 None
 0.68A 3r9cA-4unfA:
undetectable		 3r9cA-4unfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		3 / 3 ARG A  33
TRP A  29
ILE A 228
 None
 0.98A 4mwxA-4unfA:
undetectable		 4mwxA-4unfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		4 / 6 THR A  56
THR A  44
HIS A 206
ASN A 157
 None
 1.25A 4pfjB-4unfA:
undetectable		 4pfjB-4unfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		4 / 5 THR A  56
THR A  44
HIS A 206
ASN A 157
 None
 1.25A 4pgfB-4unfA:
undetectable		 4pgfB-4unfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.06A 5n0oA-4unfA:
undetectable		 5n0oA-4unfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.05A 5n0oB-4unfA:
undetectable		 5n0oB-4unfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.06A 5n0rA-4unfA:
undetectable		 5n0rA-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.04A 5n0tA-4unfA:
undetectable		 5n0tA-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.02A 5n0tB-4unfA:
undetectable		 5n0tB-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.10A 5n0wA-4unfA:
undetectable		 5n0wA-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.06A 5n0wB-4unfA:
undetectable		 5n0wB-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.06A 5n0xA-4unfA:
undetectable		 5n0xA-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.07A 5n0xB-4unfA:
undetectable		 5n0xB-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4unf ENDONUCLEASE III-1
(Deinococcus
radiodurans) 		5 / 12 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.09A 5n4iA-4unfA:
undetectable		 5n4iA-4unfA:
20.91