SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4unw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 7 LEU A 194
THR A 155
LEU A 251
GLY A 249
 None
 0.72A 1gtiB-4unwA:
undetectable		 1gtiB-4unwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 8 TYR A  56
VAL A  58
MET A 268
ILE A  88
 None
 0.95A 4a97C-4unwA:
undetectable		 4a97C-4unwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 8 TYR A  56
VAL A  58
MET A 268
ILE A  88
 None
 0.98A 4a97D-4unwA:
undetectable		 4a97D-4unwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 4 HIS A  18
ALA A  19
VAL A  20
GLU A  35
 None
 1.19A 4n6pA-4unwA:
undetectable		 4n6pA-4unwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 8 HIS A  75
ASN A  96
ARG A 224
THR A  65
 None
 1.10A 5db5A-4unwA:
undetectable
5db5B-4unwA:
undetectable		 5db5A-4unwA:
21.23
5db5B-4unwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 6 THR A 155
VAL A 130
TYR A 161
VAL A 252
 None
 1.06A 5eckA-4unwA:
undetectable		 5eckA-4unwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 6 THR A 155
VAL A 130
TYR A 161
VAL A 252
 None
 1.03A 5eckD-4unwA:
undetectable		 5eckD-4unwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 7 ASP A  73
HIS A  75
ASP A  68
ASN A  63
 None
None
None
NAG  A 421 (-1.9A)
 1.06A 5nnwD-4unwA:
undetectable		 5nnwD-4unwA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		4 / 7 ASP A  73
HIS A  75
ASP A  68
ASN A  63
 None
None
None
NAG  A 421 (-1.9A)
 1.08A 5no9D-4unwA:
undetectable		 5no9D-4unwA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4unw H3 HAEMAGGLUTININ
HA1 CHAIN
(Influenza
A
virus) 		3 / 3 ARG A 261
PHE A 120
PHE A 174
 None
 1.00A 6nknC-4unwA:
undetectable
6nknJ-4unwA:
undetectable		 6nknC-4unwA:
18.62
6nknJ-4unwA:
10.28