SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		3 / 3 THR A 152
THR A 150
PRO A 154
 None
 0.79A 1a7yB-4uobA:
undetectable		 1a7yB-4uobA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		4 / 7 LEU A 313
ALA A 255
SER A 321
SER A 319
 SF4  A1329 ( 4.8A)
SF4  A1329 ( 4.7A)
None
None
 0.98A 1dvxA-4uobA:
undetectable		 1dvxA-4uobA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		3 / 3 THR A 150
PRO A 154
THR A 152
 None
 0.87A 1i3wE-4uobA:
undetectable		 1i3wE-4uobA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		3 / 3 THR A 150
PRO A 154
THR A 152
 None
 0.87A 1i3wG-4uobA:
undetectable		 1i3wG-4uobA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		5 / 12 LEU A 104
LEU A 289
SER A 292
ALA A 256
ALA A 255
 None
None
None
None
SF4  A1329 ( 4.7A)
 1.19A 1n5xA-4uobA:
2.6		 1n5xA-4uobA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		5 / 12 LEU A 104
LEU A 289
SER A 292
ALA A 256
ALA A 255
 None
None
None
None
SF4  A1329 ( 4.7A)
 1.19A 1n5xB-4uobA:
2.6		 1n5xB-4uobA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		3 / 3 THR A 152
THR A 150
PRO A 154
 None
 0.76A 1qfiB-4uobA:
undetectable		 1qfiB-4uobA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		4 / 8 LEU A 115
PRO A 247
VAL A 294
GLY A 293
 ACT  A1334 (-4.1A)
None
None
None
 1.11A 2qd5A-4uobA:
undetectable		 2qd5A-4uobA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		5 / 12 ASN A 251
GLY A 293
GLY A 297
ASP A 299
LEU A 289
 None
 1.24A 2zw9A-4uobA:
undetectable		 2zw9A-4uobA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		4 / 4 GLY A 227
GLY A 229
THR A 232
LEU A 128
 None
ACT  A1335 (-3.4A)
ACT  A1335 (-3.7A)
None
 0.85A 3si7C-4uobA:
undetectable
3si7D-4uobA:
undetectable		 3si7C-4uobA:
21.29
3si7D-4uobA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		4 / 5 LEU A 128
GLY A 127
ILE A 186
LYS A 182
 None
 1.13A 4ma8C-4uobA:
undetectable		 4ma8C-4uobA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		4 / 5 LEU A 104
LEU A 313
PHE A 100
LEU A 261
 None
SF4  A1329 ( 4.8A)
None
None
 0.93A 5gtrA-4uobA:
undetectable		 5gtrA-4uobA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		5 / 12 ILE A 132
GLY A 126
PHE A 121
ILE A 167
LEU A 149
 None
ACT  A1333 (-3.1A)
ACT  A1333 ( 4.6A)
None
None
 1.05A 6dwnC-4uobA:
undetectable		 6dwnC-4uobA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		4 / 6 VAL A 228
LEU A 128
LEU A 202
LEU A 190
 ACT  A1335 ( 4.7A)
None
None
None
 1.05A 6f6sA-4uobA:
undetectable
6f6sB-4uobA:
undetectable		 6f6sA-4uobA:
15.50
6f6sB-4uobA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 4uob ENDONUCLEASE III-3
(Deinococcus
radiodurans) 		4 / 4 MET A 252
GLY A 297
HIS A 296
GLY A 293
 None
None
SF4  A1329 ( 4.7A)
None
 1.44A 6fgdA-4uobA:
undetectable		 6fgdA-4uobA:
21.88