SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 THR H 119
PRO H 121
THR H 120
PRO H 150
 None
 1.34A 1dsdC-4uomH:
undetectable		 1dsdC-4uomH:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 THR H 120
PRO H 150
THR H 119
PRO H 121
 None
 1.27A 1dsdC-4uomH:
undetectable		 1dsdC-4uomH:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 THR H 119
PRO H 121
THR H 120
PRO H 150
 None
 1.34A 1dsdC-4uomH:
undetectable		 1dsdC-4uomH:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 THR H 120
PRO H 150
THR H 119
PRO H 121
 None
 1.27A 1dsdC-4uomH:
undetectable		 1dsdC-4uomH:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE H 102
VAL L  59
GLY L  58
ASP H 104
 None
 1.00A 1t88A-4uomH:
undetectable		 1t88A-4uomH:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 LEU H 141
VAL H 166
GLY H 160
VAL H 186
VAL H 184
 None
 0.89A 2ieoB-4uomH:
undetectable		 2ieoB-4uomH:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 VAL L  59
THR H 101
ARG L  55
ILE L  49
ASP L  53
 None
 1.31A 2v95A-4uomL:
undetectable		 2v95A-4uomL:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 4uom FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens) 		4 / 4 LYS L  52
ALA L  65
SER L  21
THR L  75
 None
 1.38A 4i89B-4uomL:
undetectable		 4i89B-4uomL:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4uom FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 LEU L 179
ASP L 151
GLU L 154
VAL L 206
 None
 1.17A 4nkvA-4uomL:
undetectable		 4nkvA-4uomL:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE H 103
ASP H 104
PRO L  45
ILE H  34
 None
 1.03A 4pcuA-4uomH:
undetectable		 4pcuA-4uomH:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP H 104
LEU L  47
PHE H 103
 None
 0.72A 4pthA-4uomH:
undetectable		 4pthA-4uomH:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 VAL H  18
ILE H  20
VAL H 112
THR H 110
 None
 0.71A 4xdtA-4uomH:
undetectable		 4xdtA-4uomH:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens) 		4 / 4 ASN L  97
ILE H  34
TYR H  33
PHE H 102
 None
 1.49A 5igvA-4uomL:
undetectable		 5igvA-4uomL:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER H 115
ALA H 117
PHE H 149
LEU H 173
 None
 0.39A 5mthA-4uomH:
27.6		 5mthA-4uomH:
85.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4uom FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 1.06A 5vlmB-4uomL:
undetectable		 5vlmB-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4uom FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 1.09A 5vlmE-4uomL:
undetectable		 5vlmE-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4uom FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 0.97A 5vlmH-4uomL:
undetectable		 5vlmH-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ASN L  32
TYR L  37
LEU H  45
SER H  99
 None
 1.18A 6a7pA-4uomL:
undetectable		 6a7pA-4uomL:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 TYR H  60
GLY H  66
THR H  69
 None
 0.16A 6cjkB-4uomH:
25.2		 6cjkB-4uomH:
54.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 4uom FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 TYR H 148
THR H 154
CYH H 143
THR H 168
 None
 1.43A 6cnkA-4uomH:
2.7
6cnkB-4uomH:
undetectable		 6cnkA-4uomH:
15.57
6cnkB-4uomH:
15.57