SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uoo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 10 ALA A 338
LEU A 536
LEU A 314
ILE A 516
LEU A 543
 None
 1.19A 1a52A-4uooA:
undetectable		 1a52A-4uooA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 10 ALA A 338
LEU A 536
LEU A 314
ILE A 516
LEU A 543
 None
 1.19A 1a52B-4uooA:
undetectable		 1a52B-4uooA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 9 ALA A 338
LEU A 536
LEU A 314
ILE A 516
LEU A 543
 None
 1.22A 1ereC-4uooA:
undetectable		 1ereC-4uooA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 LEU A 557
THR A 538
LEU A 536
GLY A 554
 None
 0.93A 1gtiB-4uooA:
undetectable		 1gtiB-4uooA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 LEU A 558
GLY A 524
GLY A 523
GLY A 520
LYS A 255
 None
 1.13A 1y4lA-4uooA:
undetectable		 1y4lA-4uooA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 TYR A 627
GLY A 554
PHE A 553
SER A 317
 None
 1.16A 2a3cA-4uooA:
undetectable		 2a3cA-4uooA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 GLN A 510
PHE A 295
LEU A 514
ALA A 509
PHE A 268
 None
 1.41A 2g70A-4uooA:
undetectable		 2g70A-4uooA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 GLN A 510
PHE A 295
LEU A 514
ALA A 509
PHE A 268
 None
 1.39A 2g70B-4uooA:
undetectable		 2g70B-4uooA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 TYR A 319
GLY A 554
TYR A 236
ASP A 534
 None
 1.23A 2g72A-4uooA:
undetectable		 2g72A-4uooA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 GLY A 583
GLY A 582
ALA A 507
GLN A 508
GLY A 571
 None
 0.93A 2pkkA-4uooA:
undetectable		 2pkkA-4uooA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 GLY A 583
GLY A 582
ALA A 507
GLN A 508
GLY A 571
 None
 0.94A 2pkmA-4uooA:
undetectable		 2pkmA-4uooA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ALA A 338
LEU A 536
LEU A 314
ILE A 516
LEU A 543
 None
 1.15A 2qxsA-4uooA:
undetectable		 2qxsA-4uooA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 ILE A 341
LEU A 540
GLU A 315
TYR A 259
 None
 0.89A 2ya7A-4uooA:
undetectable		 2ya7A-4uooA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 ILE A 341
LEU A 540
GLU A 315
TYR A 259
 None
 0.89A 2ya7B-4uooA:
undetectable		 2ya7B-4uooA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 ILE A 341
LEU A 540
GLU A 315
TYR A 259
 None
 0.88A 2ya7D-4uooA:
undetectable		 2ya7D-4uooA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 TYR A 248
ASP A 556
ASP A 561
 None
 0.96A 3ou7B-4uooA:
1.4		 3ou7B-4uooA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ALA A 338
LEU A 536
LEU A 314
ILE A 516
LEU A 543
 None
 1.15A 3q95A-4uooA:
undetectable		 3q95A-4uooA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 TYR A 259
LEU A 539
ALA A 338
TYR A 413
 None
 1.01A 3rodD-4uooA:
undetectable		 3rodD-4uooA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 HIS A 261
HIS A 482
SER A 264
ASP A 431
 TPO  A 307 ( 4.5A)
MG  A1645 (-3.2A)
MG  A1645 ( 3.9A)
None
 1.21A 4blvA-4uooA:
2.1		 4blvA-4uooA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 LYS A 393
LYS A 395
PRO A 396
 None
 1.16A 4dv1L-4uooA:
undetectable		 4dv1L-4uooA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 11 TYR A 380
VAL A 351
ALA A 350
GLY A 354
SER A 401
 None
 1.28A 4mm9A-4uooA:
undetectable		 4mm9A-4uooA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 9 TYR A 380
VAL A 351
ALA A 350
GLY A 354
SER A 401
 None
 1.26A 4mmeA-4uooA:
undetectable		 4mmeA-4uooA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 9 TYR A 380
VAL A 351
ALA A 350
GLY A 354
SER A 401
 None
 1.26A 4mmeB-4uooA:
undetectable		 4mmeB-4uooA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		5 / 9 TYR A 380
VAL A 351
ALA A 350
GLY A 354
SER A 401
 None
 1.24A 4mmfB-4uooA:
undetectable		 4mmfB-4uooA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 LYS A 610
LEU A 614
GLU A 613
SER A 617
 None
 1.11A 4tvtA-4uooA:
undetectable		 4tvtA-4uooA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 SER A 443
TYR A 425
PHE A 423
HIS A 482
 None
None
None
MG  A1645 (-3.2A)
 1.12A 5dlvB-4uooA:
15.6		 5dlvB-4uooA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 LYS A 255
GLN A 522
ASN A 291
 None
 0.99A 5l2tA-4uooA:
undetectable		 5l2tA-4uooA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 5 TYR A 550
SER A 337
ALA A 340
GLN A 345
 None
 1.00A 5n0wB-4uooA:
2.3		 5n0wB-4uooA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 5 TYR A 550
SER A 337
ALA A 340
GLN A 345
 None
 1.03A 5n4iA-4uooA:
2.1		 5n4iA-4uooA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 HIS A 482
SER A 310
LYS A 308
 MG  A1645 (-3.2A)
TPO  A 307 ( 2.4A)
TPO  A 307 ( 2.9A)
 1.13A 5os7A-4uooA:
undetectable		 5os7A-4uooA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_ACTA504_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 4 VAL A 233
ASN A 235
LYS A 230
TYR A 627
 None
 1.45A 5yf0A-4uooA:
0.1		 5yf0A-4uooA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_ACTB502_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 4 VAL A 233
ASN A 235
LYS A 230
TYR A 627
 None
 1.47A 5yf0B-4uooA:
0.0		 5yf0B-4uooA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 HIS A 482
SER A 310
LYS A 308
 MG  A1645 (-3.2A)
TPO  A 307 ( 2.4A)
TPO  A 307 ( 2.9A)
 1.13A 6gmdB-4uooA:
undetectable		 6gmdB-4uooA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ARG A 625
LYS A 330
TYR A 335
 None
 0.84A 6gnaA-4uooA:
0.2		 6gnaA-4uooA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ARG A 625
LYS A 330
TYR A 335
 None
 0.84A 6gnbA-4uooA:
0.2		 6gnbA-4uooA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ASN A 256
PRO A 411
GLN A 409
 None
 0.95A 6jnhA-4uooA:
undetectable		 6jnhA-4uooA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 ASN A 256
PRO A 411
GLN A 409
 None
 0.95A 6jogA-4uooA:
undetectable		 6jogA-4uooA:
17.06