SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		5 / 12 ILE A 488
GLU A 544
GLN A 269
ILE A 534
ASN A 505
 None
 1.11A 1dlsA-4uopA:
3.6		 1dlsA-4uopA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 6 LYS A 586
LYS A 587
ASP A 590
ALA A 591
 None
 0.25A 1iwhA-4uopA:
undetectable		 1iwhA-4uopA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		5 / 12 ILE A 233
ILE A 512
TYR A 453
MET A 310
TYR A 287
 None
 1.49A 1ki7A-4uopA:
2.0		 1ki7A-4uopA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		5 / 12 ASP A 364
ASP A 429
ILE A 436
ASP A 441
THR A 256
 None
 1.37A 1kijA-4uopA:
undetectable		 1kijA-4uopA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 5 ILE A 307
ARG A 312
LEU A 606
PRO A 607
 None
 1.23A 1s8fA-4uopA:
undetectable
1s8fB-4uopA:
undetectable		 1s8fA-4uopA:
20.28
1s8fB-4uopA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 8 SER A 393
ASP A 364
SER A 363
GLN A 405
 None
 1.09A 2cmlC-4uopA:
undetectable		 2cmlC-4uopA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 8 SER A 393
ASP A 364
SER A 363
GLN A 405
 None
 1.11A 2cmlD-4uopA:
undetectable		 2cmlD-4uopA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		3 / 3 PHE A 271
SER A 267
GLN A 269
 None
 0.95A 3smtA-4uopA:
undetectable		 3smtA-4uopA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		3 / 3 ARG A 334
HIS A 325
TYR A 332
 None
 0.96A 4fu8A-4uopA:
undetectable		 4fu8A-4uopA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		3 / 3 ARG A 334
HIS A 325
TYR A 332
 None
 0.91A 4fu9A-4uopA:
undetectable		 4fu9A-4uopA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		3 / 3 LEU A 520
MET A 513
TYR A 222
 None
 0.89A 4p6xG-4uopA:
undetectable		 4p6xG-4uopA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		5 / 11 THR A 279
TYR A 332
HIS A 325
ILE A 390
GLN A 235
 MG  A1612 (-2.8A)
None
None
None
None
 1.42A 4rp8A-4uopA:
0.1		 4rp8A-4uopA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		5 / 12 THR A 279
TYR A 332
HIS A 325
ILE A 390
GLN A 235
 MG  A1612 (-2.8A)
None
None
None
None
 1.39A 4rp9A-4uopA:
undetectable		 4rp9A-4uopA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		5 / 12 TYR A 379
VAL A 450
SER A 448
ILE A 232
SER A 442
 None
 1.50A 4rujA-4uopA:
undetectable		 4rujA-4uopA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 6 TYR A 453
ILE A 232
TYR A 386
TYR A 338
 None
 1.32A 5igyA-4uopA:
undetectable		 5igyA-4uopA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		3 / 3 TYR A 453
TYR A 386
GLN A 388
 None
 0.93A 5jsdA-4uopA:
undetectable
5jsdB-4uopA:
undetectable		 5jsdA-4uopA:
20.41
5jsdB-4uopA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		3 / 3 TYR A 453
TYR A 386
GLN A 388
 None
 0.93A 5jsdB-4uopA:
undetectable
5jsdC-4uopA:
undetectable		 5jsdB-4uopA:
20.41
5jsdC-4uopA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 7 ASN A 536
PRO A 220
PHE A 223
TYR A 494
 None
 1.46A 5oh3A-4uopA:
undetectable		 5oh3A-4uopA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 4 LEU A 257
ASP A 258
GLN A 261
VAL A 274
 None
 0.95A 6bzoF-4uopA:
undetectable		 6bzoF-4uopA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 6 VAL A 286
PRO A 311
ALA A 282
THR A 279
 None
None
None
MG  A1612 (-2.8A)
 0.90A 6cduB-4uopA:
undetectable
6cduC-4uopA:
undetectable		 6cduB-4uopA:
22.15
6cduC-4uopA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 7 ILE A 534
LEU A 535
VAL A 449
LEU A 492
 None
1PE  A1611 ( 4.7A)
None
None
 0.74A 6g9bA-4uopA:
undetectable
6g9bB-4uopA:
undetectable		 6g9bA-4uopA:
12.54
6g9bB-4uopA:
10.66