SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 6 ALA A 216
TRP A 179
ILE A 231
ILE A 268
 None
 1.27A 2dcfA-4uouA:
undetectable		 2dcfA-4uouA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 12 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.59A 2hs1B-4uouA:
undetectable		 2hs1B-4uouA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 11 ASN A 235
VAL A 234
ILE A 231
ALA A 216
ASP A 207
 None
 1.38A 2iyfA-4uouA:
undetectable		 2iyfA-4uouA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 12 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.76A 2o4nA-4uouA:
undetectable		 2o4nA-4uouA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 6 ILE A 136
PRO A  61
LEU A  83
ILE A 112
 None
PEG  A 900 (-4.1A)
None
CSX  A 111 ( 3.8A)
 0.89A 2q83B-4uouA:
undetectable		 2q83B-4uouA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 8 TYR A  40
SER A  66
THR A 218
LEU A 283
 None
 1.20A 2v0zO-4uouA:
undetectable		 2v0zO-4uouA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 6 THR A 204
ILE A 205
THR A 213
PHE A 233
 None
 0.96A 4acbC-4uouA:
undetectable		 4acbC-4uouA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		3 / 3 TYR A  88
ARG A  73
HIS A  71
 None
 1.24A 4fubA-4uouA:
undetectable		 4fubA-4uouA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 11 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.85A 4q1xA-4uouA:
undetectable		 4q1xA-4uouA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 12 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.65A 4q1yB-4uouA:
undetectable		 4q1yB-4uouA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 4 THR A  76
GLY A  33
ASP A  30
SER A  60
 None
 1.36A 4rfqA-4uouA:
undetectable		 4rfqA-4uouA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 7 PHE A 180
ARG A 190
ILE A 178
TYR A 128
 None
 1.28A 5a06B-4uouA:
2.1		 5a06B-4uouA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		3 / 3 ASP A 193
LEU A 152
ARG A 190
 None
 0.86A 5e8qA-4uouA:
undetectable		 5e8qA-4uouA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 6 LEU A 281
VAL A  74
PHE A 220
GLY A 272
 None
 1.06A 6hd4B-4uouA:
undetectable		 6hd4B-4uouA:
13.14