SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 7 HIS A  87
THR A 199
THR A 198
TRP A  26
 CL  A 304 ( 4.9A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.94A 1am6A-4uovA:
31.2		 1am6A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 7 HIS A 112
HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 1am6A-4uovA:
31.2		 1am6A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 7 HIS A 114
HIS A 131
HIS A 112
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
AZM  A 299 (-3.3A)
 1.07A 1am6A-4uovA:
31.2		 1am6A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 8 HIS A 112
HIS A 114
HIS A 131
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.35A 1azmA-4uovA:
30.5		 1azmA-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 8 HIS A 112
HIS A 114
HIS A 131
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.32A 1bzmA-4uovA:
30.5		 1bzmA-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.33A 1cilA-4uovA:
31.3		 1cilA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.10A 1cilA-4uovA:
31.3		 1cilA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 11 HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.36A 1dmyA-4uovA:
27.7		 1dmyA-4uovA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.37A 1dmyB-4uovA:
27.8		 1dmyB-4uovA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.92A 1dmyB-4uovA:
27.8		 1dmyB-4uovA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_A_AZMA1400_1
(CARBONIC ANHYDRASE
XII)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.43A 1jd0A-4uovA:
30.4		 1jd0A-4uovA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_A_AZMA1400_1
(CARBONIC ANHYDRASE
XII)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 9 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 1jd0A-4uovA:
30.4		 1jd0A-4uovA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.49A 1jd0B-4uovA:
30.0		 1jd0B-4uovA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.39A 1jd0B-4uovA:
30.0		 1jd0B-4uovA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.46A 1jd0B-4uovA:
30.0		 1jd0B-4uovA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.06A 1jd0B-4uovA:
30.0		 1jd0B-4uovA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
HIS A 112
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.47A 1jd0B-4uovA:
30.0		 1jd0B-4uovA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 ASN A  85
HIS A 114
LEU A 197
THR A 198
PRO A 201
 None
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.00A 1oq5A-4uovA:
31.3		 1oq5A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 0.49A 1oq5A-4uovA:
31.3		 1oq5A-4uovA:
36.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 VAL A 160
ASN A  84
VAL A 228
MET A 229
LEU A 174
 None
None
B3P  A 301 (-3.5A)
None
None
 1.08A 1r9oA-4uovA:
undetectable		 1r9oA-4uovA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 GLN A 110
HIS A  87
VAL A 133
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
CL  A 304 ( 4.9A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 1rj6A-4uovA:
30.3		 1rj6A-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.37A 1rj6A-4uovA:
30.3		 1rj6A-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.05A 1rj6A-4uovA:
30.3		 1rj6A-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
HIS A 112
THR A 199
THR A 198
TRP A  26
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.43A 1rj6A-4uovA:
30.3		 1rj6A-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 131
LEU A 135
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
PEG  A 305 (-4.3A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.92A 1rj6A-4uovA:
30.3		 1rj6A-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 GLN A 110
HIS A  87
VAL A 133
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
CL  A 304 ( 4.9A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 1rj6B-4uovA:
30.0		 1rj6B-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.37A 1rj6B-4uovA:
30.0		 1rj6B-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.05A 1rj6B-4uovA:
30.0		 1rj6B-4uovA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDA_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 10 GLN A 110
HIS A 112
HIS A 131
VAL A 133
VAL A 143
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.32A 1ydaA-4uovA:
31.1		 1ydaA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 11 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.27A 1ydbA-4uovA:
31.3		 1ydbA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
THR A 198
THR A 199
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.26A 1yddA-4uovA:
31.3		 1yddA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
HIS A 112
VAL A 133
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.42A 1yddA-4uovA:
31.3		 1yddA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 HIS A  87
GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.45A 1z9yA-4uovA:
31.2		 1z9yA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A  87
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 4.9A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.31A 1z9yA-4uovA:
31.2		 1z9yA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 ASN A  85
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 None
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.12A 1zgfA-4uovA:
31.3		 1zgfA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 HIS A  87
GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.39A 1zgfA-4uovA:
31.3		 1zgfA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A  87
HIS A 114
VAL A 143
LEU A 197
THR A 199
 CL  A 304 ( 4.9A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.11A 1zgfA-4uovA:
31.3		 1zgfA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 131
HIS A  87
THR A 199
THR A 198
TRP A  26
 ZN  A 298 ( 3.2A)
CL  A 304 ( 4.9A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.03A 1zgfA-4uovA:
31.3		 1zgfA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.47A 1zsbA-4uovA:
31.4		 1zsbA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.35A 1zsbA-4uovA:
31.4		 1zsbA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 1zsbA-4uovA:
31.4		 1zsbA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.04A 1zsbA-4uovA:
31.4		 1zsbA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.28A 2aw1A-4uovA:
31.1		 2aw1A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 6 TRP A  26
HIS A  87
GLN A 110
THR A 199
PRO A 201
 None
CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
AZM  A 299 (-3.3A)
None
 0.54A 2ez7A-4uovA:
30.8		 2ez7A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 8 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.27A 2gehA-4uovA:
31.0		 2gehA-4uovA:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 LEU A 108
VAL A  99
VAL A 101
ILE A 209
ALA A 130
 None
 1.16A 2gj5A-4uovA:
undetectable		 2gj5A-4uovA:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4N_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 9 GLN A 110
HIS A 114
HIS A 131
VAL A 133
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.45A 2h4nA-4uovA:
31.2		 2h4nA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 8 HIS A 112
HIS A 114
HIS A 131
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.42A 2it4A-4uovA:
30.2		 2it4A-4uovA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 ASN A  85
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 None
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.12A 2pouA-4uovA:
31.0		 2pouA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 HIS A  87
GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.42A 2pouA-4uovA:
31.0		 2pouA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A  87
HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
 CL  A 304 ( 4.9A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.17A 2pouA-4uovA:
31.0		 2pouA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A  87
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 4.9A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.46A 2pouA-4uovA:
31.0		 2pouA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 ASN A  85
HIS A  87
GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.47A 3bl1A-4uovA:
30.9		 3bl1A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.11A 3bl1A-4uovA:
30.9		 3bl1A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 131
HIS A  87
THR A 199
THR A 198
TRP A  26
 ZN  A 298 ( 3.2A)
CL  A 304 ( 4.9A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.09A 3bl1A-4uovA:
30.9		 3bl1A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.44A 3cajA-4uovA:
31.1		 3cajA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.10A 3cajA-4uovA:
31.1		 3cajA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.51A 3czvA-4uovA:
31.1
3czvB-4uovA:
31.2		 3czvA-4uovA:
35.13
3czvB-4uovA:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZV_B_AZMB263_1
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.45A 3czvB-4uovA:
31.2		 3czvB-4uovA:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.31A 3dazA-4uovA:
31.4		 3dazA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.44A 3dazA-4uovA:
31.4		 3dazA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.11A 3dazA-4uovA:
31.4		 3dazA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.50A 3dc3A-4uovA:
31.5		 3dc3A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.34A 3dc3A-4uovA:
31.5		 3dc3A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 3dc3A-4uovA:
31.5		 3dc3A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.05A 3dc3A-4uovA:
31.5		 3dc3A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.37A 3dcsA-4uovA:
31.4		 3dcsA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.48A 3dcsA-4uovA:
31.4		 3dcsA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.40A 3dcwA-4uovA:
31.4		 3dcwA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
HIS A 112
VAL A 133
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.36A 3dcwA-4uovA:
31.4		 3dcwA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.98A 3dcwA-4uovA:
31.4		 3dcwA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.40A 3dd0A-4uovA:
31.3		 3dd0A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
PRO A 201
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.18A 3dd0A-4uovA:
31.3		 3dd0A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.49A 3dd0A-4uovA:
31.3		 3dd0A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.99A 3dd0A-4uovA:
31.3		 3dd0A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F4X_A_KLTA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.39A 3f4xA-4uovA:
30.8		 3f4xA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F4X_A_KLTA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 12 ASN A  85
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
 None
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.06A 3f4xA-4uovA:
30.8		 3f4xA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F4X_A_KLTA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.49A 3f4xA-4uovA:
30.8		 3f4xA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F4X_A_KLTA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 12 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.14A 3f4xA-4uovA:
30.8		 3f4xA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
ILE A 141
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.45A 3fw3A-4uovA:
28.5		 3fw3A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
ILE A 141
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.33A 3fw3A-4uovA:
28.5		 3fw3A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		12 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
ILE A 141
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.33A 3fw3B-4uovA:
28.4		 3fw3B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
ILE A 141
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.32A 3fw3B-4uovA:
28.4		 3fw3B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.36A 3hkuA-4uovA:
31.1		 3hkuA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 ASN A  85
HIS A 114
VAL A 133
LEU A 197
THR A 199
 None
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.04A 3hkuA-4uovA:
31.1		 3hkuA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.40A 3hkuA-4uovA:
31.1		 3hkuA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		3 / 3 GLU A 118
HIS A 131
THR A 198
 AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.3A)
 0.10A 3hkuA-4uovA:
31.1		 3hkuA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.31A 3hs4A-4uovA:
31.4		 3hs4A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.50A 3hs4A-4uovA:
31.4		 3hs4A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.08A 3hs4A-4uovA:
31.4		 3hs4A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.22A 3iaiA-4uovA:
30.2		 3iaiA-4uovA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
GLU A 118
VAL A 143
LEU A 197
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.94A 3iaiA-4uovA:
30.2		 3iaiA-4uovA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.22A 3iaiB-4uovA:
30.2		 3iaiB-4uovA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.20A 3iaiC-4uovA:
30.1		 3iaiC-4uovA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
GLU A 118
VAL A 143
LEU A 197
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.93A 3iaiC-4uovA:
30.1		 3iaiC-4uovA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.21A 3iaiD-4uovA:
30.2		 3iaiD-4uovA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
GLU A 118
VAL A 143
LEU A 197
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.91A 3iaiD-4uovA:
30.2		 3iaiD-4uovA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.49A 3kwaA-4uovA:
30.9		 3kwaA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 112
HIS A 131
VAL A 143
THR A 198
PRO A 200
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.3A)
None
None
 1.30A 3kwaA-4uovA:
30.9		 3kwaA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 12 HIS A  87
GLN A 110
HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.67A 3lxeA-4uovA:
30.4		 3lxeA-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 12 HIS A  87
GLN A 110
HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.64A 3lxeB-4uovA:
30.5		 3lxeB-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.39A 3mdzA-4uovA:
30.7		 3mdzA-4uovA:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 11 HIS A 114
GLU A 118
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.06A 3mdzA-4uovA:
30.7		 3mdzA-4uovA:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.22A 3ml5A-4uovA:
31.2		 3ml5A-4uovA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.28A 3v2jA-4uovA:
31.4		 3v2jA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.48A 3v2jA-4uovA:
31.4		 3v2jA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.04A 3v2jA-4uovA:
31.4		 3v2jA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.29A 3v2mA-4uovA:
31.4		 3v2mA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.49A 3v2mA-4uovA:
31.4		 3v2mA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.94A 3v2mA-4uovA:
31.4		 3v2mA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.38A 3v2mA-4uovA:
31.4		 3v2mA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 8 GLN A 110
HIS A  87
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
CL  A 304 ( 4.9A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.87A 3w6hA-4uovA:
30.3		 3w6hA-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 8 GLN A 110
HIS A 112
HIS A 114
HIS A 131
HIS A  87
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
CL  A 304 ( 4.9A)
 1.07A 3w6hA-4uovA:
30.3		 3w6hA-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 8 GLN A 110
HIS A 112
HIS A 114
HIS A 131
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.42A 3w6hA-4uovA:
30.3		 3w6hA-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_B_AZMB303_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 9 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.42A 3w6hB-4uovA:
30.3		 3w6hB-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_B_AZMB303_1
(CARBONIC ANHYDRASE 1)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
HIS A  87
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
CL  A 304 ( 4.9A)
 1.06A 3w6hB-4uovA:
30.3		 3w6hB-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.47A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.48A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.10A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.49A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 7 LEU A 197
GLU A 129
HIS A 131
HIS A 112
 AZM  A 299 (-3.8A)
None
ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
 1.24A 4aq7A-4uovA:
undetectable		 4aq7A-4uovA:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_A_SANA300_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.17A 4coqA-4uovA:
41.1		 4coqA-4uovA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_A_SANA300_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.96A 4coqA-4uovA:
41.1		 4coqA-4uovA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.20A 4coqB-4uovA:
41.2		 4coqB-4uovA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 9 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.49A 4coqB-4uovA:
41.2		 4coqB-4uovA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.98A 4coqB-4uovA:
41.2		 4coqB-4uovA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.40A 4coqB-4uovA:
41.2		 4coqB-4uovA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 10 GLN A 110
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
VAL A 206
TRP A 208
 CL  A 304 ( 3.7A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.56A 4e3hA-4uovA:
31.1		 4e3hA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 4g0cA-4uovA:
31.3		 4g0cA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.13A 4g0cA-4uovA:
31.3		 4g0cA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_A_AZMA302_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.44A 4g7aA-4uovA:
34.7		 4g7aA-4uovA:
45.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_A_AZMA302_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.19A 4g7aA-4uovA:
34.7		 4g7aA-4uovA:
45.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_A_AZMA302_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.02A 4g7aA-4uovA:
34.7		 4g7aA-4uovA:
45.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_A_AZMA302_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
HIS A 112
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.46A 4g7aA-4uovA:
34.7		 4g7aA-4uovA:
45.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.46A 4g7aB-4uovA:
34.3		 4g7aB-4uovA:
45.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.17A 4g7aB-4uovA:
34.3		 4g7aB-4uovA:
45.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.95A 4g7aB-4uovA:
34.3		 4g7aB-4uovA:
45.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 GLN A 110
HIS A  87
LEU A 135
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
CL  A 304 ( 4.9A)
PEG  A 305 (-4.3A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.29A 4k0sA-4uovA:
31.4		 4k0sA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 135
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
PEG  A 305 (-4.3A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.93A 4k0sA-4uovA:
31.4		 4k0sA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.30A 4k0sA-4uovA:
31.4		 4k0sA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.06A 4k0sA-4uovA:
31.4		 4k0sA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
LEU A 135
LEU A 197
THR A 198
THR A 199
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
PEG  A 305 (-4.3A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.88A 4k0zA-4uovA:
31.3		 4k0zA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.45A 4k0zA-4uovA:
31.3		 4k0zA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 12 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.18A 4k0zA-4uovA:
31.3		 4k0zA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.50A 4k0zA-4uovA:
31.3		 4k0zA-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 135
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
PEG  A 305 (-4.3A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.97A 4k13A-4uovA:
31.4		 4k13A-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.28A 4k13A-4uovA:
31.4		 4k13A-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.48A 4k13A-4uovA:
31.4		 4k13A-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.34A 4lu3A-4uovA:
30.0		 4lu3A-4uovA:
30.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.39A 4m2rA-4uovA:
31.4		 4m2rA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.45A 4m2rA-4uovA:
31.4		 4m2rA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.01A 4m2rA-4uovA:
31.4		 4m2rA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2U_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 TRP A  26
GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.34A 4m2uA-4uovA:
31.4		 4m2uA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2U_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 TRP A  26
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.23A 4m2uA-4uovA:
31.4		 4m2uA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2U_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 12 TRP A  37
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 199
TRP A 208
 None
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.50A 4m2uA-4uovA:
31.4		 4m2uA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
GLY A 139
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
PEG  A 305 ( 4.5A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.23A 4m2vA-4uovA:
31.5		 4m2vA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.30A 4m2vA-4uovA:
31.5		 4m2vA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 LEU A 135
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 PEG  A 305 (-4.3A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.15A 4m2vA-4uovA:
31.5		 4m2vA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.29A 4m2wA-4uovA:
31.4		 4m2wA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.48A 4m2wA-4uovA:
31.4		 4m2wA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 LEU A 135
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 PEG  A 305 (-4.3A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.14A 4m2wA-4uovA:
31.4		 4m2wA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 8 GLN A 110
HIS A 112
HIS A 114
HIS A 131
THR A 198
THR A 199
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.30A 4n16A-4uovA:
31.5		 4n16A-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PXX_A_CHDA302_0
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
THR A 198
THR A 199
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.29A 4pxxA-4uovA:
31.3		 4pxxA-4uovA:
37.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 PHE A 128
ALA A 115
VAL A  82
LEU A 183
LEU A 157
 None
 1.11A 4qzuC-4uovA:
undetectable		 4qzuC-4uovA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_A_ASCA303_0
(DIOSCORIN 5)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 133
VAL A 143
THR A 198
TRP A 208
 ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.3A)
None
 0.33A 4twlA-4uovA:
31.1		 4twlA-4uovA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 133
VAL A 143
THR A 198
TRP A 208
 ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.3A)
None
 0.30A 4twlB-4uovA:
31.5		 4twlB-4uovA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_A_AZMA302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.48A 4x5sA-4uovA:
35.2		 4x5sA-4uovA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_A_AZMA302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.16A 4x5sA-4uovA:
35.2		 4x5sA-4uovA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_A_AZMA302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.95A 4x5sA-4uovA:
35.2		 4x5sA-4uovA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_B_AZMB302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.48A 4x5sB-4uovA:
35.2		 4x5sB-4uovA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_B_AZMB302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.15A 4x5sB-4uovA:
35.2		 4x5sB-4uovA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_A_AZMA402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 12 GLN A 110
HIS A 112
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.41A 4xiwA-4uovA:
28.9
4xiwH-4uovA:
28.8		 4xiwA-4uovA:
37.74
4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_A_AZMA402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.29A 4xiwA-4uovA:
28.9
4xiwH-4uovA:
28.8		 4xiwA-4uovA:
37.74
4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_A_AZMA402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.02A 4xiwA-4uovA:
28.9
4xiwH-4uovA:
28.8		 4xiwA-4uovA:
37.74
4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 4xiwB-4uovA:
28.7
4xiwE-4uovA:
28.9		 4xiwB-4uovA:
37.74
4xiwE-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_C_AZMC402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 11 GLN A 110
HIS A 112
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.34A 4xiwC-4uovA:
28.7		 4xiwC-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_C_AZMC402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.32A 4xiwC-4uovA:
28.7		 4xiwC-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_C_AZMC402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.88A 4xiwC-4uovA:
28.7		 4xiwC-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_D_AZMD402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.39A 4xiwD-4uovA:
29.0		 4xiwD-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_D_AZMD402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 4xiwD-4uovA:
29.0		 4xiwD-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_D_AZMD402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.91A 4xiwD-4uovA:
29.0		 4xiwD-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 11 GLN A 110
HIS A 112
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.42A 4xiwE-4uovA:
28.9		 4xiwE-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.20A 4xiwE-4uovA:
28.9		 4xiwE-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.94A 4xiwE-4uovA:
28.9		 4xiwE-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.45A 4xiwF-4uovA:
28.8		 4xiwF-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.24A 4xiwF-4uovA:
28.8		 4xiwF-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.05A 4xiwF-4uovA:
28.8		 4xiwF-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.40A 4xiwG-4uovA:
28.7		 4xiwG-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 11 GLN A 110
HIS A 112
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.41A 4xiwH-4uovA:
28.8		 4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.28A 4xiwH-4uovA:
28.8		 4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.08A 4xiwH-4uovA:
28.8		 4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 11 LYS A  90
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.50A 4ygfA-4uovA:
30.3		 4ygfA-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 11 HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.35A 4ygfB-4uovA:
30.3		 4ygfB-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.82A 4ygfB-4uovA:
30.3		 4ygfB-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 11 LYS A  90
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.43A 4ygfC-4uovA:
22.3		 4ygfC-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 11 HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.35A 4ygfD-4uovA:
4.6		 4ygfD-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.12A 4ygfD-4uovA:
4.6		 4ygfD-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.37A 4ygfD-4uovA:
4.6		 4ygfD-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.84A 4ygfE-4uovA:
30.5		 4ygfE-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 LYS A  90
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.49A 4ygfE-4uovA:
30.5		 4ygfE-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_F_AZMF303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 9 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.27A 4ygfF-4uovA:
30.1		 4ygfF-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 12 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.30A 4ygfG-4uovA:
7.6		 4ygfG-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 12 LYS A  90
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.50A 4ygfG-4uovA:
7.6		 4ygfG-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_H_AZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 9 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.25A 4ygfH-4uovA:
30.2		 4ygfH-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_H_AZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 HIS A 114
HIS A 112
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 4ygfH-4uovA:
30.2		 4ygfH-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 LYS A  90
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.50A 4yhaA-4uovA:
30.4		 4yhaA-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 10 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.50A 4yhaB-4uovA:
29.6		 4yhaB-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 11 LYS A  90
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.49A 4yhaC-4uovA:
30.5		 4yhaC-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 11 LYS A  90
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.46A 4yhaD-4uovA:
29.3		 4yhaD-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 114
VAL A 143
LEU A 197
THR A 198
PRO A 201
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.21A 4yhaE-4uovA:
30.6		 4yhaE-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 LYS A  90
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
PRO A 201
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 0.54A 4yhaE-4uovA:
30.6		 4yhaE-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 LYS A  90
HIS A 112
HIS A 131
THR A 198
PRO A 200
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.3A)
None
None
 1.39A 4yhaE-4uovA:
30.6		 4yhaE-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 10 HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.58A 4yhaF-4uovA:
27.4		 4yhaF-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 LYS A  90
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 4.8A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.49A 4yhaG-4uovA:
29.8		 4yhaG-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 10 HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.38A 4yhaH-4uovA:
29.9		 4yhaH-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 GLN A 110
HIS A 112
GLU A 129
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
None
AZM  A 299 ( 4.8A)
None
 1.35A 5c8iA-4uovA:
31.4		 5c8iA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 GLN A 110
HIS A 112
HIS A 114
GLU A 118
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.43A 5c8iA-4uovA:
31.4		 5c8iA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
PRO A 201
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.16A 5c8iA-4uovA:
31.4		 5c8iA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 12 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.00A 5c8iA-4uovA:
31.4		 5c8iA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_A_AZMA701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.22A 5jn8A-4uovA:
28.1		 5jn8A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_A_AZMA701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
HIS A 112
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 5jn8A-4uovA:
28.1		 5jn8A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_A_AZMA701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.02A 5jn8A-4uovA:
28.1		 5jn8A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
 CL  A 304 ( 3.7A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
 1.46A 5jn8B-4uovA:
28.5		 5jn8B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.22A 5jn8B-4uovA:
28.5		 5jn8B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.01A 5jn8B-4uovA:
28.5		 5jn8B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_C_AZMC701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.21A 5jn8C-4uovA:
28.1		 5jn8C-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.17A 5jn8D-4uovA:
27.8		 5jn8D-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_A_EZLA302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 GLN A 110
HIS A  87
VAL A 133
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
CL  A 304 ( 4.9A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.28A 5jn9A-4uovA:
28.2		 5jn9A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_A_EZLA302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 5jn9A-4uovA:
28.2		 5jn9A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 5jn9B-4uovA:
28.6		 5jn9B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.92A 5jn9B-4uovA:
28.6		 5jn9B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.42A 5jn9B-4uovA:
28.6		 5jn9B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_C_EZLC302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.25A 5jn9C-4uovA:
28.1		 5jn9C-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_C_EZLC302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 9 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.49A 5jn9C-4uovA:
28.1		 5jn9C-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_C_EZLC302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.99A 5jn9C-4uovA:
28.1		 5jn9C-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_C_EZLC302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.42A 5jn9C-4uovA:
28.1		 5jn9C-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 5jn9D-4uovA:
27.8		 5jn9D-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
HIS A 112
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.40A 5jn9D-4uovA:
27.8		 5jn9D-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.50A 5jn9D-4uovA:
27.8		 5jn9D-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.00A 5jn9D-4uovA:
27.8		 5jn9D-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.35A 5jnaA-4uovA:
28.2		 5jnaA-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.07A 5jnaA-4uovA:
28.2		 5jnaA-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.35A 5jnaB-4uovA:
28.5		 5jnaB-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.45A 5jnaB-4uovA:
28.5		 5jnaB-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 11 ASN A  85
GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.35A 5jnaC-4uovA:
28.0		 5jnaC-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.50A 5jnaC-4uovA:
28.0		 5jnaC-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.02A 5jnaC-4uovA:
28.0		 5jnaC-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 12 ASN A  85
GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.32A 5jnaD-4uovA:
27.8		 5jnaD-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.00A 5jnaD-4uovA:
27.8		 5jnaD-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 11 GLN A 110
HIS A 112
GLU A 129
VAL A 133
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
None
AZM  A 299 (-3.3A)
 1.30A 5jncA-4uovA:
28.2		 5jncA-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		11 / 11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.25A 5jncA-4uovA:
28.2		 5jncA-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 11 HIS A 114
GLU A 118
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.03A 5jncA-4uovA:
28.2		 5jncA-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.23A 5jncB-4uovA:
28.6		 5jncB-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
HIS A 112
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.42A 5jncB-4uovA:
28.6		 5jncB-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.40A 5jncB-4uovA:
28.6		 5jncB-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_C_6LHC302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.21A 5jncC-4uovA:
28.0		 5jncC-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_D_6LHD302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 GLN A 110
HIS A  87
VAL A 133
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
CL  A 304 ( 4.9A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.28A 5jncD-4uovA:
27.8		 5jncD-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_D_6LHD302_0
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.17A 5jncD-4uovA:
27.8		 5jncD-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.24A 5ku6A-4uovA:
28.1		 5ku6A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.02A 5ku6A-4uovA:
28.1		 5ku6A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 10 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.22A 5ku6B-4uovA:
28.5		 5ku6B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
HIS A 112
VAL A 133
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.42A 5ku6B-4uovA:
28.5		 5ku6B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.43A 5ku6B-4uovA:
28.5		 5ku6B-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.21A 5ku6C-4uovA:
28.1		 5ku6C-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_D_MZMD301_1
(CARBONIC ANHYDRASE 4)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.20A 5ku6D-4uovA:
27.8		 5ku6D-4uovA:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 8 TYR A  28
TRP A  26
CYH A 202
TRP A  37
 None
 1.44A 5kxiA-4uovA:
undetectable
5kxiB-4uovA:
undetectable		 5kxiA-4uovA:
18.99
5kxiB-4uovA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 8 TYR A  28
TRP A  26
CYH A 202
TRP A  37
 None
 1.45A 5kxiD-4uovA:
undetectable
5kxiE-4uovA:
undetectable		 5kxiD-4uovA:
18.99
5kxiE-4uovA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 7 GLN A 110
HIS A 112
VAL A 133
LEU A 197
THR A 198
THR A 199
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.28A 5m78A-4uovA:
31.2		 5m78A-4uovA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 7 GLN A 110
HIS A 112
VAL A 133
LEU A 197
THR A 199
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.46A 5m78A-4uovA:
31.2		 5m78A-4uovA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 7 VAL A 143
LEU A 197
THR A 198
THR A 199
 AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 0.91A 5m78A-4uovA:
31.2		 5m78A-4uovA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 6 HIS A 112
HIS A 131
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.40A 5ogjA-4uovA:
31.0		 5ogjA-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 6 HIS A 112
HIS A 114
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.22A 5ogjB-4uovA:
30.5		 5ogjB-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 6 HIS A 112
HIS A 131
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.40A 5ogjB-4uovA:
30.5		 5ogjB-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 5 HIS A 112
HIS A 114
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.23A 5ohhA-4uovA:
30.4		 5ohhA-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 5 HIS A 112
HIS A 131
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.41A 5ohhA-4uovA:
30.4		 5ohhA-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		4 / 6 HIS A 112
HIS A 114
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.22A 5ohhB-4uovA:
30.9		 5ohhB-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 6 HIS A 112
HIS A 131
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.38A 5ohhB-4uovA:
30.9		 5ohhB-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 10 HIS A 112
HIS A 114
HIS A 131
THR A 198
PRO A 200
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.3A)
None
None
 1.34A 5tt3A-4uovA:
30.1		 5tt3A-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
PRO A 201
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 0.45A 5tt3A-4uovA:
30.1		 5tt3A-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 9 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.37A 5tt3B-4uovA:
28.1		 5tt3B-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 10 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
PRO A 201
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 0.37A 5tt3C-4uovA:
30.6		 5tt3C-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 10 HIS A 114
VAL A 133
LEU A 197
THR A 198
PRO A 201
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.85A 5tt3C-4uovA:
30.6		 5tt3C-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 9 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.36A 5tt3E-4uovA:
30.5		 5tt3E-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 9 HIS A 114
HIS A 131
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.50A 5tt3E-4uovA:
30.5		 5tt3E-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.48A 5tt3E-4uovA:
30.5		 5tt3E-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 8 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.34A 5tt3F-4uovA:
29.4		 5tt3F-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		8 / 9 HIS A 112
HIS A 114
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.31A 5tt3G-4uovA:
29.5		 5tt3G-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 9 HIS A 131
HIS A 114
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.41A 5tt3G-4uovA:
29.5		 5tt3G-4uovA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 8 HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.41A 5tt3H-4uovA:
29.8		 5tt3H-4uovA:
36.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		3 / 3 GLU A 118
TRP A 208
HIS A 112
 AZM  A 299 ( 4.4A)
None
ZN  A 298 (-3.2A)
 1.07A 5xipA-4uovA:
undetectable		 5xipA-4uovA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		3 / 3 GLU A 129
TRP A 208
HIS A 112
 None
None
ZN  A 298 (-3.2A)
 1.08A 5xipA-4uovA:
undetectable		 5xipA-4uovA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		9 / 12 TRP A  26
ASN A  85
GLN A 110
HIS A 112
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.52A 6bbsA-4uovA:
25.2		 6bbsA-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		5 / 12 TRP A  26
HIS A 112
THR A 198
THR A 199
TRP A 208
 None
ZN  A 298 (-3.2A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.17A 6bbsA-4uovA:
25.2		 6bbsA-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 TRP A  26
ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.38A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 TRP A  26
GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.54A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		7 / 12 TRP A  26
HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
PRO A 201
 None
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.30A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 TRP A  26
HIS A 112
LEU A 197
THR A 199
PRO A 201
TRP A 208
 None
ZN  A 298 (-3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 1.31A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 TRP A  26
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.23A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		10 / 12 GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.42A 6bccA-4uovA:
31.4		 6bccA-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 4uov CARBONATE
DEHYDRATASE
(Thermovibrio
ammonificans) 		6 / 12 HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
 ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.99A 6bccA-4uovA:
31.4		 6bccA-4uovA:
14.52