SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4uow OBSCURIN
TITIN
(Homo
sapiens) 		5 / 10 GLY 1  89
ILE 0  14
ILE 0  94
ILE 0  65
ALA 1  93
 None
 1.07A 1sh9B-4uow1:
undetectable		 1sh9B-4uow1:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4uow TITIN
(Homo
sapiens) 		4 / 5 LEU 1  29
LEU 1  67
ILE 1  69
ARG 1  55
 None
 0.73A 2qd4A-4uow1:
undetectable		 2qd4A-4uow1:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4uow OBSCURIN
TITIN
(Homo
sapiens) 		4 / 7 ASN 0  93
ILE 0  14
PHE 1  92
GLN 1  47
 None
None
CL  0 201 (-4.8A)
None
 1.22A 3tvxB-4uow0:
undetectable		 3tvxB-4uow0:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4uow TITIN
(Homo
sapiens) 		4 / 5 LEU 1  29
LEU 1  67
ILE 1  69
ARG 1  55
 None
 0.76A 4klrA-4uow1:
undetectable		 4klrA-4uow1:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4uow TITIN
(Homo
sapiens) 		4 / 8 GLU 1  90
GLY 1  35
THR 1  14
PHE 1  92
 None
None
None
CL  0 201 (-4.8A)
 1.00A 5flcF-4uow1:
undetectable		 5flcF-4uow1:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4uow TITIN
(Homo
sapiens) 		3 / 3 ARG 1  57
ILE 1  69
PHE 1  56
 None
 0.69A 5kirA-4uow1:
undetectable		 5kirA-4uow1:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4uow OBSCURIN
TITIN
(Homo
sapiens) 		4 / 6 ALA 1  94
GLN 1  79
GLN 1  47
ASP 0  13
 None
 1.31A 5y9aA-4uow1:
undetectable		 5y9aA-4uow1:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4uow OBSCURIN
TITIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLN 1  79
VAL 1  95
PRO 0  11
THR 1  14
 None
 1.32A 6cduI-4uow1:
undetectable
6cduJ-4uow1:
undetectable		 6cduI-4uow1:
13.71
6cduJ-4uow1:
13.71