SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uoz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		3 / 3 PHE A  25
LEU A 322
SER A 348
 None
 0.93A 1e7aA-4uozA:
undetectable		 1e7aA-4uozA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ILE A  53
GLY A  26
CYH A 360
LEU A 352
LEU A 395
 None
 1.47A 1fm6X-4uozA:
undetectable		 1fm6X-4uozA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		3 / 3 PHE A 135
TRP A  61
GLU A  65
 None
 0.94A 1mogA-4uozA:
undetectable		 1mogA-4uozA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 7 ASP A 562
ASP A 565
GLY A 525
ILE A 524
 None
 0.81A 1t7jB-4uozA:
undetectable		 1t7jB-4uozA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 5 ILE A 423
LEU A 233
ALA A 428
GLU A 430
 None
 1.22A 1xvaA-4uozA:
undetectable
1xvaB-4uozA:
undetectable		 1xvaA-4uozA:
17.88
1xvaB-4uozA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 LEU A 254
LEU A 263
GLY A 162
ALA A  93
ALA A  57
 None
 1.05A 2br4A-4uozA:
undetectable		 2br4A-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 LEU A 254
LEU A 263
GLY A 162
ALA A  93
ALA A  57
 None
 1.09A 2br4D-4uozA:
undetectable		 2br4D-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 LEU A 254
LEU A 263
GLY A 162
ALA A  93
ALA A  57
 None
 1.09A 2br4E-4uozA:
undetectable		 2br4E-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ALA A 507
SER A 506
ALA A 487
GLY A 525
GLY A 522
 None
 1.11A 2igtA-4uozA:
undetectable		 2igtA-4uozA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ALA A 507
SER A 506
ALA A 487
GLY A 525
GLY A 522
 None
 1.14A 2igtB-4uozA:
2.2		 2igtB-4uozA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 5 VAL A 593
THR A 592
VAL A 530
GLY A 529
 PGE  A1698 (-4.4A)
None
None
None
 1.12A 2p2fA-4uozA:
undetectable		 2p2fA-4uozA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 4 VAL A 593
THR A 592
VAL A 530
GLY A 529
 PGE  A1698 (-4.4A)
None
None
None
 1.14A 2p2fB-4uozA:
3.7		 2p2fB-4uozA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 8 ILE A  43
TYR A 389
ASP A  42
ARG A 365
 None
 0.99A 2v57A-4uozA:
undetectable		 2v57A-4uozA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 8 ILE A  43
TYR A 389
ASP A  42
ARG A 365
 None
 0.99A 2v57C-4uozA:
0.5		 2v57C-4uozA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 11 PHE A 493
ASP A 469
VAL A 479
ILE A 476
VAL A 527
 None
 1.44A 2vcdA-4uozA:
undetectable		 2vcdA-4uozA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ILE A  58
ALA A  95
MET A 146
LEU A  76
ILE A 156
 None
 1.28A 2zzaA-4uozA:
undetectable		 2zzaA-4uozA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 11 ILE A  58
ALA A  95
MET A 146
LEU A  76
ILE A 156
 None
 1.27A 2zzaB-4uozA:
undetectable		 2zzaB-4uozA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ILE A  58
ALA A  95
MET A 146
LEU A  76
ILE A 156
 None
 1.32A 3ia4B-4uozA:
undetectable		 3ia4B-4uozA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 10 ARG A 658
ILE A 301
ASN A 659
LEU A 638
VAL A 661
 None
 1.13A 3o02A-4uozA:
undetectable
3o02B-4uozA:
undetectable		 3o02A-4uozA:
17.55
3o02B-4uozA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 10 ASP A 302
ALA A 305
LEU A 412
ILE A  23
ILE A 672
 None
 1.19A 3prsA-4uozA:
undetectable		 3prsA-4uozA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 4 ASP A 631
ASP A 629
GLY A 635
THR A 458
 None
 1.29A 3tl9B-4uozA:
undetectable		 3tl9B-4uozA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		3 / 3 LEU A  45
MET A 378
ASP A 391
 None
 0.80A 3v5wA-4uozA:
undetectable		 3v5wA-4uozA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 5 SER A 614
GLY A 612
TRP A 448
ASP A 447
 None
 1.42A 3w9tB-4uozA:
undetectable		 3w9tB-4uozA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 5 SER A 614
GLY A 612
TRP A 448
ASP A 447
 None
 1.42A 3w9tC-4uozA:
undetectable		 3w9tC-4uozA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 5 SER A 614
GLY A 612
TRP A 448
ASP A 447
 None
 1.43A 3w9tD-4uozA:
undetectable		 3w9tD-4uozA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		3 / 3 PRO A 521
TYR A 603
GLY A 529
 None
 0.48A 4g2zA-4uozA:
undetectable		 4g2zA-4uozA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 7 ALA A 579
PRO A 581
LEU A 546
LEU A 549
 None
 0.76A 4iomA-4uozA:
2.0		 4iomA-4uozA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 LEU A 538
ALA A 589
TYR A 504
ILE A 439
LEU A 608
 None
 1.34A 4l9qA-4uozA:
undetectable		 4l9qA-4uozA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB304_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 4 GLY A 313
SER A 315
ARG A 316
PRO A 463
 None
 1.17A 4m93B-4uozA:
0.0
4m93C-4uozA:
0.0		 4m93B-4uozA:
15.43
4m93C-4uozA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 7 TYR A 306
ASN A 274
GLU A 426
GLU A 441
 None
 1.09A 4mi4A-4uozA:
undetectable
4mi4C-4uozA:
undetectable		 4mi4A-4uozA:
14.24
4mi4C-4uozA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 LEU A 140
GLY A 162
ALA A 139
ASN A 169
GLY A 166
 None
 0.91A 4n09A-4uozA:
4.0		 4n09A-4uozA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 LEU A 140
GLY A 162
ALA A 139
ASN A 169
GLY A 166
 None
 0.87A 4n09D-4uozA:
4.2		 4n09D-4uozA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		3 / 3 ASP A  77
LEU A  76
PHE A  73
 None
 0.65A 4pthA-4uozA:
undetectable		 4pthA-4uozA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		6 / 9 ALA A 605
ILE A 524
VAL A 527
THR A 571
ILE A 604
VAL A 601
 None
 1.47A 4r21B-4uozA:
undetectable		 4r21B-4uozA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 4 GLU A 164
GLY A 166
HIS A 168
ARG A 125
 GLA  A 701 (-3.1A)
None
None
GLA  A 701 (-2.7A)
 1.34A 4r82A-4uozA:
undetectable
4r82B-4uozA:
undetectable		 4r82A-4uozA:
14.88
4r82B-4uozA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 10 PHE A 577
ALA A 590
VAL A 557
LEU A 538
LEU A 560
 None
 1.21A 4zmeB-4uozA:
undetectable		 4zmeB-4uozA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ILE A 476
VAL A 475
PHE A 501
VAL A 551
LEU A 608
 None
 0.81A 5ergB-4uozA:
undetectable		 5ergB-4uozA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ASP A 562
ALA A 561
ASP A 586
PHE A 577
GLY A 584
 None
 1.29A 5hfjF-4uozA:
undetectable		 5hfjF-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ASP A 562
ALA A 561
ASP A 586
PHE A 577
GLY A 584
 None
 1.28A 5hfjH-4uozA:
undetectable		 5hfjH-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 PHE A 449
SER A 309
ALA A 466
TYR A 471
GLY A 313
 None
 1.25A 5tzoA-4uozA:
undetectable		 5tzoA-4uozA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 PHE A 449
SER A 309
ALA A 466
TYR A 471
GLY A 313
 None
 1.27A 5tzoC-4uozA:
undetectable		 5tzoC-4uozA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 SER A 410
LEU A 671
ALA A 353
ILE A 359
ALA A 358
 None
 1.05A 5vc0A-4uozA:
undetectable		 5vc0A-4uozA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 9 ASP A 513
GLY A 230
ASN A 228
TYR A 480
ALA A 509
 None
 1.29A 5x66C-4uozA:
undetectable		 5x66C-4uozA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 10 ASP A 513
GLY A 230
ASN A 228
TYR A 480
ALA A 509
 None
 1.32A 5x66D-4uozA:
undetectable		 5x66D-4uozA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		5 / 12 ILE A  58
ALA A  95
MET A 146
LEU A  76
ILE A 156
 None
 1.28A 5z6fA-4uozA:
undetectable		 5z6fA-4uozA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 6 GLU A 245
ARG A 136
PHE A 246
PRO A 130
 None
 1.50A 6fgdA-4uozA:
3.3		 6fgdA-4uozA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 6 ASP A 559
TYR A 504
GLU A 444
ASP A 447
 None
 1.14A 6mn5A-4uozA:
undetectable		 6mn5A-4uozA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 6 ASP A 559
TYR A 504
GLU A 444
ASP A 447
 None
 1.17A 6mn5C-4uozA:
undetectable		 6mn5C-4uozA:
8.76