SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4up5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 PHE A1238
ARG A 356
ASN A1244
 None
 0.93A 1xzxX-4up5A:
undetectable		 1xzxX-4up5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 7 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 0.88A 4pfjA-4up5A:
undetectable		 4pfjA-4up5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.09A 5axaA-4up5A:
undetectable		 5axaA-4up5A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.07A 5axaC-4up5A:
undetectable		 5axaC-4up5A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8A-4up5A:
undetectable		 5hm8A-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8B-4up5A:
undetectable		 5hm8B-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8C-4up5A:
undetectable		 5hm8C-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8D-4up5A:
undetectable		 5hm8D-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8E-4up5A:
undetectable		 5hm8E-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8F-4up5A:
undetectable		 5hm8F-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8G-4up5A:
undetectable		 5hm8G-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8H-4up5A:
undetectable		 5hm8H-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.08A 5v96A-4up5A:
undetectable		 5v96A-4up5A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.08A 5v96B-4up5A:
undetectable		 5v96B-4up5A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.10A 5v96C-4up5A:
undetectable		 5v96C-4up5A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.08A 5v96D-4up5A:
undetectable		 5v96D-4up5A:
11.37