SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4up7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 7 LEU A 186
GLY A 190
LEU A 192
TYR A 244
 None
 0.99A 1gtiD-4up7A:
undetectable		 1gtiD-4up7A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 7 LEU A 186
GLY A 190
LEU A 192
TYR A 244
 None
 1.00A 1gtiE-4up7A:
undetectable		 1gtiE-4up7A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 8 GLU A 562
SER A   2
GLU A 571
GLU A 574
 None
 1.17A 1knyA-4up7A:
undetectable
1knyB-4up7A:
undetectable		 1knyA-4up7A:
15.04
1knyB-4up7A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 11 LEU A 126
GLY A 111
LEU A 134
LEU A  75
LEU A  82
 None
 1.10A 1mx1A-4up7A:
undetectable		 1mx1A-4up7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 8 SER A  31
VAL A  56
PRO A 116
HIS A 115
 None
 1.07A 2ddwA-4up7A:
2.2		 2ddwA-4up7A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 11 PHE A 191
LEU A 230
ILE A 523
ALA A 522
ARG A 242
 None
 1.44A 2v0mA-4up7A:
undetectable		 2v0mA-4up7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 5 TYR A  41
ILE A  32
LEU A  82
LEU A 126
 None
 1.18A 2zb7A-4up7A:
undetectable		 2zb7A-4up7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 7 ARG A 251
PHE A 250
ILE A 198
ASN A 200
 LAD  A1584 (-2.3A)
None
None
None
 1.23A 2zseA-4up7A:
undetectable		 2zseA-4up7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 GLN A 451
HIS A 462
ASP A 450
GLU A 229
PRO A 457
 None
None
None
LAD  A1584 (-3.6A)
None
 1.40A 3b7pA-4up7A:
undetectable		 3b7pA-4up7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 249
ARG A 251
GLU A 267
ALA A 459
GLU A 487
 None
LAD  A1584 (-2.3A)
LAD  A1584 (-3.3A)
None
LAD  A1584 (-2.6A)
 1.13A 3k37A-4up7A:
undetectable		 3k37A-4up7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 409
PHE A 408
ILE A 396
LEU A 400
ASP A 401
 None
 1.06A 3ko0G-4up7A:
undetectable
3ko0H-4up7A:
undetectable
3ko0I-4up7A:
undetectable
3ko0J-4up7A:
undetectable		 3ko0G-4up7A:
9.51
3ko0H-4up7A:
9.51
3ko0I-4up7A:
9.51
3ko0J-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 11 LEU A 400
ASP A 401
LEU A 409
PHE A 408
ILE A 396
 None
 1.13A 3ko0A-4up7A:
undetectable
3ko0B-4up7A:
0.9
3ko0I-4up7A:
undetectable
3ko0J-4up7A:
undetectable		 3ko0A-4up7A:
9.51
3ko0B-4up7A:
9.51
3ko0I-4up7A:
9.51
3ko0J-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 409
PHE A 408
ILE A 396
LEU A 400
ASP A 401
 None
 1.09A 3ko0K-4up7A:
undetectable
3ko0L-4up7A:
undetectable
3ko0S-4up7A:
undetectable
3ko0T-4up7A:
undetectable		 3ko0K-4up7A:
9.51
3ko0L-4up7A:
9.51
3ko0S-4up7A:
9.51
3ko0T-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 400
ASP A 401
LEU A 409
PHE A 408
ILE A 396
 None
 1.09A 3ko0K-4up7A:
undetectable
3ko0L-4up7A:
undetectable
3ko0M-4up7A:
undetectable
3ko0N-4up7A:
undetectable		 3ko0K-4up7A:
9.51
3ko0L-4up7A:
9.51
3ko0M-4up7A:
9.51
3ko0N-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 409
PHE A 408
ILE A 396
LEU A 400
ASP A 401
 None
 1.06A 3ko0M-4up7A:
undetectable
3ko0N-4up7A:
undetectable
3ko0O-4up7A:
undetectable
3ko0P-4up7A:
undetectable		 3ko0M-4up7A:
9.51
3ko0N-4up7A:
9.51
3ko0O-4up7A:
9.51
3ko0P-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 5 PRO A 445
ILE A 537
TRP A 533
PHE A 375
 None
 1.16A 3topB-4up7A:
undetectable		 3topB-4up7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 4 PRO A 452
LEU A 400
ILE A 396
ARG A 398
 None
 1.43A 3w1wA-4up7A:
undetectable		 3w1wA-4up7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		3 / 3 TYR A 231
ASP A 516
ASP A 521
 None
 0.77A 4a6eA-4up7A:
undetectable		 4a6eA-4up7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 7 VAL A 547
LEU A 543
MET A 289
VAL A 290
 None
 1.07A 4e1gB-4up7A:
undetectable		 4e1gB-4up7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 8 ARG A 251
PHE A 263
GLY A 534
THR A 265
 LAD  A1584 (-2.3A)
LAD  A1584 (-3.5A)
LAD  A1584 ( 3.9A)
LAD  A1584 (-4.5A)
 0.82A 4k87A-4up7A:
10.9		 4k87A-4up7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		3 / 3 TYR A 275
GLN A 451
TRP A 533
 None
 1.07A 4kn2C-4up7A:
undetectable		 4kn2C-4up7A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 249
ARG A 251
GLU A 267
ALA A 459
GLU A 487
 None
LAD  A1584 (-2.3A)
LAD  A1584 (-3.3A)
None
LAD  A1584 (-2.6A)
 1.30A 4mx0A-4up7A:
undetectable		 4mx0A-4up7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 5 PHE A 112
ILE A 104
GLY A 131
ILE A  73
 None
 0.91A 5dzkd-4up7A:
undetectable
5dzkk-4up7A:
undetectable
5dzky-4up7A:
undetectable		 5dzkd-4up7A:
14.94
5dzkk-4up7A:
14.03
5dzky-4up7A:
0.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		7 / 10 ARG A 251
GLU A 253
HIS A 259
PHE A 263
GLY A 536
ARG A 539
ILE A 550
 LAD  A1584 (-2.3A)
LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
LAD  A1584 (-3.5A)
LAD  A1584 ( 3.7A)
LAD  A1584 (-4.1A)
None
 0.35A 6bniA-4up7A:
48.3		 6bniA-4up7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 10 GLU A 253
HIS A 259
GLU A 480
ARG A 539
ILE A 550
 LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
None
LAD  A1584 (-4.1A)
None
 1.07A 6bniA-4up7A:
48.3		 6bniA-4up7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		7 / 10 ARG A 251
GLU A 253
HIS A 259
PHE A 263
GLY A 536
ARG A 539
ILE A 550
 LAD  A1584 (-2.3A)
LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
LAD  A1584 (-3.5A)
LAD  A1584 ( 3.7A)
LAD  A1584 (-4.1A)
None
 0.34A 6bniB-4up7A:
48.5		 6bniB-4up7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 10 GLU A 253
HIS A 259
GLU A 480
ARG A 539
ILE A 550
 LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
None
LAD  A1584 (-4.1A)
None
 1.08A 6bniB-4up7A:
48.5		 6bniB-4up7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 8 VAL A 164
LEU A 160
ILE A 163
ARG A 106
 None
 0.83A 6cb4A-4up7A:
undetectable		 6cb4A-4up7A:
21.03