SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 4 HIS A  57
LEU A  20
LEU A  96
LEU A 393
 None
 1.18A 1a4lD-4uphA:
undetectable		 1a4lD-4uphA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 LEU A  89
SER A  87
ASN A  85
 None
None
DDZ  A  64 ( 4.0A)
 0.74A 1bx4A-4uphA:
undetectable		 1bx4A-4uphA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 6 PHE A  58
ALA A 330
GLY A 347
TYR A 349
 None
 1.13A 1c8lA-4uphA:
undetectable		 1c8lA-4uphA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 10 HIS A  80
ALA A  59
HIS A 498
SER A 373
ALA A 374
 None
 1.36A 1gtnO-4uphA:
undetectable
1gtnP-4uphA:
undetectable		 1gtnO-4uphA:
10.02
1gtnP-4uphA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 10 THR A 380
PRO A 379
GLY A 396
LEU A 353
THR A 372
 None
 1.33A 1h4oA-4uphA:
undetectable
1h4oB-4uphA:
undetectable		 1h4oA-4uphA:
14.50
1h4oB-4uphA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 THR A 380
CYH A 382
VAL A  18
ILE A 377
LEU A 322
 None
 1.26A 1z9hA-4uphA:
undetectable		 1z9hA-4uphA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 THR A 380
CYH A 382
VAL A  18
ILE A 377
LEU A 322
 None
 1.27A 1z9hB-4uphA:
undetectable		 1z9hB-4uphA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 THR A 380
CYH A 382
VAL A  18
ILE A 377
LEU A 322
 None
 1.26A 1z9hC-4uphA:
undetectable		 1z9hC-4uphA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 SER A 348
ALA A  59
PHE A  58
ALA A 414
 None
 0.93A 2bxmA-4uphA:
undetectable		 2bxmA-4uphA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		6 / 12 HIS A 392
GLY A  74
ASN A  95
LEU A  96
ASP A 394
LEU A  75
 None
 1.46A 2f8lA-4uphA:
undetectable		 2f8lA-4uphA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 LYS A  15
TYR A 105
PRO A  16
 None
CL  A1549 ( 4.1A)
None
 1.15A 2j9cC-4uphA:
undetectable		 2j9cC-4uphA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 ASP A 239
SER A  38
TYR A 295
HIS A  36
 None
 1.36A 2v0gA-4uphA:
undetectable		 2v0gA-4uphA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 PHE A 325
THR A  41
ILE A 377
GLY A  28
 None
 0.77A 2v0mB-4uphA:
undetectable		 2v0mB-4uphA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 11 LEU A 197
PHE A 218
ALA A  23
ARG A 356
LEU A 305
 None
 1.02A 2v0mD-4uphA:
undetectable		 2v0mD-4uphA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 TYR A 112
SER A 217
HIS A 329
SER A 327
 None
None
MG  A1001 (-3.1A)
None
 1.12A 2vmyA-4uphA:
undetectable
2vmyB-4uphA:
undetectable		 2vmyA-4uphA:
21.33
2vmyB-4uphA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 5 PHE A  58
ALA A 330
GLY A 347
TYR A 349
 None
 1.13A 3bcrA-4uphA:
undetectable		 3bcrA-4uphA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 HIS A 498
LEU A  71
PHE A 415
SER A 373
LEU A 353
 None
 1.37A 3bxoA-4uphA:
undetectable		 3bxoA-4uphA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 6 PHE A  58
ALA A 330
GLY A 347
TYR A 349
 None
 1.16A 3ddsA-4uphA:
undetectable		 3ddsA-4uphA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 349
ARG A  84
ASN A  85
ALA A  67
 None
None
DDZ  A  64 ( 4.0A)
DDZ  A  64 ( 3.7A)
 1.39A 3frqB-4uphA:
undetectable		 3frqB-4uphA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 GLN A 151
LEU A 197
LEU A 109
THR A 113
ARG A 203
 None
 1.41A 3fsuA-4uphA:
undetectable		 3fsuA-4uphA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 6 PRO A 458
HIS A 256
LEU A 460
ALA A 475
 None
 1.33A 3gv1A-4uphA:
undetectable
3gv1C-4uphA:
undetectable		 3gv1A-4uphA:
12.88
3gv1C-4uphA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 ILE A 290
SER A 226
SER A 181
 None
 0.49A 3iltH-4uphA:
undetectable		 3iltH-4uphA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 9 ILE A 377
LEU A 402
THR A 321
LEU A 305
GLY A  51
 None
 1.37A 3nxuB-4uphA:
undetectable		 3nxuB-4uphA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 5 TYR A 480
LEU A 492
LYS A 490
ARG A 484
 None
 0.91A 3sudD-4uphA:
undetectable		 3sudD-4uphA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 TYR A 480
LEU A 492
LYS A 490
 None
 0.69A 3sueD-4uphA:
undetectable		 3sueD-4uphA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 TYR A 480
LEU A 492
ARG A 484
 None
 0.79A 3sufB-4uphA:
undetectable		 3sufB-4uphA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 PRO A 107
HIS A 215
LEU A  71
ALA A  97
 None
 0.63A 3tehB-4uphA:
undetectable		 3tehB-4uphA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 6 ARG A 411
PHE A 401
PRO A 407
LEU A 398
 None
 1.35A 3tgvB-4uphA:
undetectable		 3tgvB-4uphA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 5 ARG A 411
PHE A 401
PRO A 407
LEU A 398
 None
 1.32A 3tgvC-4uphA:
undetectable		 3tgvC-4uphA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 HIS A 329
LYS A 341
TYR A 294
ASP A  24
 MG  A1001 (-3.1A)
DDZ  A  64 ( 4.6A)
None
MG  A1001 (-1.9A)
 1.08A 4l7iB-4uphA:
undetectable		 4l7iB-4uphA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 ASP A  29
ARG A 291
PRO A 241
 None
 1.00A 4wanC-4uphA:
undetectable		 4wanC-4uphA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 THR A 192
ALA A 195
LEU A 197
HIS A 161
LEU A 156
 None
 1.35A 4xi3A-4uphA:
undetectable		 4xi3A-4uphA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 PHE A 415
ARG A 495
ILE A 444
TYR A 451
 None
 1.35A 5a06B-4uphA:
undetectable		 5a06B-4uphA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 5 THR A 194
ALA A 195
THR A 192
TYR A 187
 None
 1.37A 5ecmA-4uphA:
undetectable		 5ecmA-4uphA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 445
HIS A 350
ARG A  56
 None
 1.16A 5iaoC-4uphA:
undetectable		 5iaoC-4uphA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 445
HIS A 350
ARG A  56
 None
 1.14A 5iaoF-4uphA:
undetectable		 5iaoF-4uphA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 ILE A 324
LEU A  20
ASP A 376
ALA A 375
LEU A 398
 None
 1.00A 5km9B-4uphA:
undetectable		 5km9B-4uphA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 ASP A 302
THR A 303
LEU A 305
VAL A 354
 None
 1.25A 5ov9B-4uphA:
undetectable		 5ov9B-4uphA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 5 VAL A 443
HIS A 336
LEU A 461
ASP A 346
 None
 1.05A 5vcvA-4uphA:
undetectable		 5vcvA-4uphA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 SER A  22
HIS A 215
TYR A  72
 None
 0.76A 5y2tA-4uphA:
undetectable		 5y2tA-4uphA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 SER A  22
HIS A 215
ILE A 298
LEU A  71
TYR A  72
 None
 1.48A 5ycpA-4uphA:
undetectable		 5ycpA-4uphA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 GLY A  51
LEU A  53
VAL A 368
GLY A 306
ASP A 302
 None
 1.16A 6gngA-4uphA:
undetectable		 6gngA-4uphA:
22.68