SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4upl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 LEU A 403
ILE A 400
ARG A 364
VAL A   0
ALA A 384
 None
 1.01A 1e7aA-4uplA:
undetectable		 1e7aA-4uplA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 ALA A 191
ALA A 291
LEU A 295
ALA A 299
ILE A 229
 None
 0.95A 1fk6A-4uplA:
undetectable		 1fk6A-4uplA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 TRP A 186
HIS A 232
MET A 136
 None
 0.78A 1l5qB-4uplA:
undetectable		 1l5qB-4uplA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 PRO A 350
ILE A  48
GLY A 328
ILE A  44
THR A 340
 None
 1.25A 1sg9A-4uplA:
undetectable		 1sg9A-4uplA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 7 GLU A 338
HIS A 232
TYR A 145
ILE A  48
 None
 1.18A 1tuvA-4uplA:
undetectable		 1tuvA-4uplA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 GLU A 373
THR A 380
LEU A 377
LEU A 399
 None
 1.10A 1u18B-4uplA:
undetectable		 1u18B-4uplA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 ASP A 146
GLU A 203
ARG A 158
 None
 0.88A 1wopA-4uplA:
undetectable		 1wopA-4uplA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 ALA A 269
ILE A 426
ASN A 430
ILE A 432
 None
 1.10A 2h4jA-4uplA:
undetectable		 2h4jA-4uplA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 TYR A 292
ASP A  14
HIS A 327
 None
None
ZN  A1553 (-3.2A)
 0.90A 3e23A-4uplA:
undetectable		 3e23A-4uplA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 ARG A  60
GLU A 373
ASP A 413
 None
 0.82A 3g2oA-4uplA:
undetectable		 3g2oA-4uplA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 MET A  90
MET A  79
PHE A 381
 None
 0.76A 3gn8A-4uplA:
undetectable		 3gn8A-4uplA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 7 LEU A 490
TYR A 487
VAL A 471
MET A 439
 None
 1.32A 3ik3A-4uplA:
undetectable		 3ik3A-4uplA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 7 LEU A 490
TYR A 487
VAL A 471
MET A 439
 None
 1.32A 3ik3B-4uplA:
undetectable		 3ik3B-4uplA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 8 ASP A 301
TYR A 241
LEU A  11
PRO A 231
 None
 1.18A 3jq7B-4uplA:
undetectable		 3jq7B-4uplA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 ALA A 172
ILE A 236
ILE A 229
PRO A 138
LEU A 137
 None
 1.27A 3u7sB-4uplA:
undetectable		 3u7sB-4uplA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 TYR A 538
GLU A 529
TYR A 525
 None
 0.84A 3ug8A-4uplA:
undetectable		 3ug8A-4uplA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 ARG A 101
ASP A   9
GLN A  10
 None
ZN  A1553 (-2.2A)
None
 0.58A 4azsA-4uplA:
undetectable		 4azsA-4uplA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 8 HIS A 327
LYS A 339
TYR A 292
ASP A   9
 ZN  A1553 (-3.2A)
None
None
ZN  A1553 (-2.2A)
 0.91A 4k0bB-4uplA:
undetectable		 4k0bB-4uplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 8 HIS A 327
LYS A 339
TYR A 292
ASP A   9
 ZN  A1553 (-3.2A)
None
None
ZN  A1553 (-2.2A)
 0.94A 4l7iB-4uplA:
undetectable		 4l7iB-4uplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 ASP A 329
HIS A 232
TYR A 292
ALA A 287
GLY A 294
 None
 1.33A 4lb9A-4uplA:
0.1		 4lb9A-4uplA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 SER A 498
GLN A 499
THR A  58
ARG A  60
 None
 1.38A 4lnxA-4uplA:
undetectable		 4lnxA-4uplA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 GLN A  10
ASP A   9
HIS A 327
GLU A 338
 None
ZN  A1553 (-2.2A)
ZN  A1553 (-3.2A)
None
 0.99A 4qyqC-4uplA:
undetectable		 4qyqC-4uplA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 ARG A  12
GLU A 338
TYR A 292
 None
 0.70A 4r29D-4uplA:
undetectable		 4r29D-4uplA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 ASP A  14
HIS A  21
TYR A 292
GLN A 251
ILE A 289
 None
 1.26A 4ypaC-4uplA:
undetectable		 4ypaC-4uplA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 ARG A 121
GLY A 119
SER A 116
LEU A 117
 None
 1.24A 5bphA-4uplA:
undetectable		 5bphA-4uplA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 GLN A  10
ASP A   9
HIS A 327
GLU A 338
 None
ZN  A1553 (-2.2A)
ZN  A1553 (-3.2A)
None
 0.99A 5hpwC-4uplA:
undetectable		 5hpwC-4uplA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 PHE A   8
THR A 204
ASP A 133
GLY A 135
 None
 1.24A 5mraA-4uplA:
undetectable
5mraB-4uplA:
undetectable		 5mraA-4uplA:
13.40
5mraB-4uplA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 THR A  98
ARG A 132
ASP A 133
GLY A 135
 None
 1.08A 5mraA-4uplA:
undetectable
5mraB-4uplA:
undetectable		 5mraA-4uplA:
13.40
5mraB-4uplA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 HIS A 479
VAL A 482
LEU A 449
TRP A 447
 None
 1.32A 5ogjA-4uplA:
undetectable		 5ogjA-4uplA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 THR A  58
MET A  81
HIS A  84
 None
 0.89A 5uunA-4uplA:
undetectable		 5uunA-4uplA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 HIS A 409
LEU A 463
ARG A 412
ALA A 443
VAL A 442
 None
 1.36A 6c2mB-4uplA:
undetectable		 6c2mB-4uplA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 LEU A 399
SER A 398
ILE A 353
VAL A  37
ILE A 402
 None
 1.21A 6ef6A-4uplA:
undetectable		 6ef6A-4uplA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4upl SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		5 / 6 LEU A 490
TYR A 487
VAL A 471
PHE A 440
MET A 439
 None
 1.47A 6hd4B-4uplA:
undetectable		 6hd4B-4uplA:
9.47