SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 5 MET A  18
HIS A  51
ILE A 162
HIS A 113
 None
 1.35A 1osvB-4uq9A:
undetectable		 1osvB-4uq9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 124
ARG A  67
ASP A  26
 None
 0.95A 2qe6A-4uq9A:
undetectable		 2qe6A-4uq9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 124
ARG A  67
ASP A  26
 None
 0.91A 2qe6B-4uq9A:
undetectable		 2qe6B-4uq9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		7 / 12 TRP A  81
ASN A 135
GLU A 136
HIS A 198
TYR A 200
GLU A 225
TRP A 264
 None
 0.44A 2v3dA-4uq9A:
33.3		 2v3dA-4uq9A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		6 / 11 TRP A  81
ASN A 135
GLU A 136
TYR A 200
GLU A 225
TRP A 264
 None
 0.49A 2v3dB-4uq9A:
33.1		 2v3dB-4uq9A:
24.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KL3_B_DHIB404_0
(GLUCURONOXYLANASE
XYNC)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 4 GLU A 136
TYR A 139
TYR A 200
TYR A 227
 None
 0.32A 3kl3B-4uq9A:
32.5		 3kl3B-4uq9A:
68.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 209
VAL A 262
MET A 178
ARG A  13
 None
 1.08A 3ms9B-4uq9A:
undetectable		 3ms9B-4uq9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 311
ASN A 309
ILE A 328
MET A 285
 None
 1.12A 3tvxB-4uq9A:
undetectable		 3tvxB-4uq9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLN A 374
THR A 372
ASN A 338
 None
 0.75A 3v4tE-4uq9A:
undetectable		 3v4tE-4uq9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_1
(METTL3)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ASP A  53
HIS A 113
ASN A 135
GLN A 134
 None
 1.27A 5il1A-4uq9A:
1.0		 5il1A-4uq9A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 THR A 344
THR A 371
ARG A 347
 None
 0.95A 5wm2A-4uq9A:
undetectable		 5wm2A-4uq9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 HIS A 250
ASN A 248
TYR A 261
GLU A 244
 None
 1.46A 6gneA-4uq9A:
undetectable		 6gneA-4uq9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 289
HIS A 247
ASN A 248
TYR A 261
 None
 1.31A 6gneA-4uq9A:
undetectable		 6gneA-4uq9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 289
HIS A 247
ASN A 248
TYR A 261
 None
 1.31A 6gneB-4uq9A:
undetectable		 6gneB-4uq9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4uq9 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 THR A  34
LEU A  43
THR A  28
LEU A  48
 None
 1.22A 6mvxA-4uq9A:
undetectable
6mvxB-4uq9A:
undetectable
6mvxC-4uq9A:
undetectable		 6mvxA-4uq9A:
22.86
6mvxB-4uq9A:
22.86
6mvxC-4uq9A:
22.86