SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 443
LEU A 447
LEU A 318
GLY A 334
 None
 0.94A 1a4lC-4uqgA:
undetectable		 1a4lC-4uqgA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 VAL A 746
MET A 750
ASN A 709
ILE A 736
 None
 0.96A 1e06A-4uqgA:
undetectable		 1e06A-4uqgA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 833
LEU A 825
GLU A 835
LEU A 824
 None
 0.76A 1eupA-4uqgA:
undetectable		 1eupA-4uqgA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 761
PRO A 774
ASP A 402
ALA A 404
 None
 0.98A 1gxsA-4uqgA:
undetectable
1gxsB-4uqgA:
undetectable		 1gxsA-4uqgA:
15.83
1gxsB-4uqgA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 474
GLU A 464
LEU A 401
LEU A 394
 None
 0.99A 1mt1D-4uqgA:
1.8
1mt1E-4uqgA:
undetectable		 1mt1D-4uqgA:
10.54
1mt1E-4uqgA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A 390
VAL A 320
ALA A 377
LEU A 387
 None
 0.82A 1pthA-4uqgA:
undetectable		 1pthA-4uqgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A 390
VAL A 320
ALA A 377
LEU A 387
 None
 0.82A 1pthB-4uqgA:
undetectable		 1pthB-4uqgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 340
ASN A 339
TRP A 455
 None
 1.00A 1r15C-4uqgA:
undetectable		 1r15C-4uqgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 340
ASN A 339
TRP A 455
 None
 1.02A 1r15D-4uqgA:
undetectable		 1r15D-4uqgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 340
ASN A 339
TRP A 455
 None
 1.02A 1r15E-4uqgA:
undetectable		 1r15E-4uqgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 340
ASN A 339
TRP A 455
 None
 1.03A 1r15F-4uqgA:
undetectable		 1r15F-4uqgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 523
ALA A 522
ILE A 528
VAL A 536
ILE A 537
 None
 0.96A 1sduB-4uqgA:
undetectable		 1sduB-4uqgA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 725
ILE A 712
THR A 685
HIS A 682
GLN A 656
 None
None
None
SO4  A 880 (-4.6A)
None
 1.45A 1tw4B-4uqgA:
undetectable		 1tw4B-4uqgA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
 None
 0.97A 1xiuA-4uqgA:
undetectable		 1xiuA-4uqgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 485
ALA A 609
LEU A 610
SER A 617
LEU A 616
 None
SUC  A 877 ( 4.0A)
None
None
None
 1.23A 2c12C-4uqgA:
3.4		 2c12C-4uqgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 485
ALA A 609
LEU A 610
SER A 617
LEU A 616
 None
SUC  A 877 ( 4.0A)
None
None
None
 1.24A 2c12F-4uqgA:
3.5		 2c12F-4uqgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A 872
LEU A 500
ARG A 637
GLY A 633
 None
 1.11A 2hs2B-4uqgA:
undetectable		 2hs2B-4uqgA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 662
TYR A 749
ILE A 712
ILE A 796
 None
 0.99A 2q8hA-4uqgA:
undetectable		 2q8hA-4uqgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 523
ALA A 522
ILE A 528
VAL A 536
ILE A 537
 None
 0.97A 3d1xB-4uqgA:
undetectable		 3d1xB-4uqgA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 11 TYR A 654
LEU A 766
ALA A 807
LEU A 616
THR A 765
 None
 1.42A 3jwqB-4uqgA:
3.9
3jwqC-4uqgA:
undetectable		 3jwqB-4uqgA:
19.45
3jwqC-4uqgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 805
ARG A 769
ASP A 393
 None
 1.46A 3o7wA-4uqgA:
undetectable		 3o7wA-4uqgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 616
THR A 765
HIS A 664
ILE A 665
ILE A 657
 None
 1.29A 3sp9A-4uqgA:
undetectable		 3sp9A-4uqgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 587
ASN A 625
ILE A 626
PHE A 640
 None
 1.19A 3tvxB-4uqgA:
undetectable		 3tvxB-4uqgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 704
THR A 698
ASN A 700
 None
 0.89A 3v4tE-4uqgA:
undetectable		 3v4tE-4uqgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 590
ILE A 626
LEU A 623
PHE A 640
 None
 0.66A 4ejjD-4uqgA:
undetectable		 4ejjD-4uqgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 517
GLU A 569
ASN A 573
 None
 0.91A 4ip7D-4uqgA:
undetectable		 4ip7D-4uqgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 624
HIS A 829
ARG A 615
 None
 1.21A 4qyqA-4uqgA:
undetectable		 4qyqA-4uqgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 624
HIS A 829
ARG A 615
 None
 1.22A 4qyqB-4uqgA:
undetectable		 4qyqB-4uqgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 334
ILE A 332
TYR A 429
VAL A 437
LEU A 380
 None
None
SO4  A 881 (-4.5A)
None
None
 1.44A 5nz0A-4uqgA:
2.0		 5nz0A-4uqgA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A 770
ASP A 463
LEU A 465
ASP A 471
 None
 1.07A 5tdzA-4uqgA:
undetectable		 5tdzA-4uqgA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
 None
 0.96A 5uanA-4uqgA:
undetectable		 5uanA-4uqgA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
 None
 1.03A 5z12C-4uqgA:
undetectable		 5z12C-4uqgA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
 None
 0.96A 6a5yD-4uqgA:
undetectable		 6a5yD-4uqgA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
 None
 1.02A 6a60D-4uqgA:
undetectable		 6a60D-4uqgA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 422
ALA A 453
LEU A 443
PHE A 345
LEU A 303
 None
 1.41A 6a7pB-4uqgA:
1.5		 6a7pB-4uqgA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 715
ARG A 703
ILE A 689
ALA A 707
ALA A 705
 None
 1.00A 6c2mD-4uqgA:
undetectable		 6c2mD-4uqgA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 680
ILE A 681
ARG A 702
ASN A 670
 SO4  A 880 ( 4.8A)
None
SO4  A 880 (-3.0A)
None
 1.14A 6hisA-4uqgA:
undetectable
6hisB-4uqgA:
undetectable		 6hisA-4uqgA:
11.09
6hisB-4uqgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 680
ILE A 681
ARG A 702
ASN A 670
 SO4  A 880 ( 4.8A)
None
SO4  A 880 (-3.0A)
None
 1.14A 6hisB-4uqgA:
undetectable
6hisC-4uqgA:
undetectable		 6hisB-4uqgA:
11.09
6hisC-4uqgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 680
ILE A 681
ARG A 702
ASN A 670
 SO4  A 880 ( 4.8A)
None
SO4  A 880 (-3.0A)
None
 1.13A 6hisC-4uqgA:
undetectable
6hisD-4uqgA:
undetectable		 6hisC-4uqgA:
11.09
6hisD-4uqgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 680
ILE A 681
ARG A 702
ASN A 670
 SO4  A 880 ( 4.8A)
None
SO4  A 880 (-3.0A)
None
 1.15A 6hisD-4uqgA:
undetectable
6hisE-4uqgA:
undetectable		 6hisD-4uqgA:
11.09
6hisE-4uqgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASN A 670
ASP A 680
ILE A 681
ARG A 702
 None
SO4  A 880 ( 4.8A)
None
SO4  A 880 (-3.0A)
 1.14A 6hisA-4uqgA:
undetectable
6hisE-4uqgA:
undetectable		 6hisA-4uqgA:
11.09
6hisE-4uqgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 314
SER A 369
SER A 391
 None
 0.77A 6mxtA-4uqgA:
undetectable		 6mxtA-4uqgA:
22.70