SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 7 TYR A  85
VAL A  98
ILE A 111
TYR A 112
GLY A 128
 CL  A1245 (-4.3A)
None
None
None
None
 1.08A 11gsA-4uqmA:
undetectable		 11gsA-4uqmA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 10 TYR A  85
VAL A  98
ILE A 111
TYR A 112
GLY A 128
 CL  A1245 (-4.3A)
None
None
None
None
 1.13A 13gsA-4uqmA:
undetectable		 13gsA-4uqmA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 12 TYR A 112
VAL A 138
ALA A 134
LEU A 130
GLN A 136
 None
 1.18A 1udtA-4uqmA:
undetectable		 1udtA-4uqmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 8 TYR A  85
VAL A  98
ILE A 111
TYR A 112
GLY A 128
 CL  A1245 (-4.3A)
None
None
None
None
 1.10A 2gssA-4uqmA:
undetectable		 2gssA-4uqmA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 8 TYR A  85
VAL A  98
ILE A 111
TYR A 112
GLY A 128
 CL  A1245 (-4.3A)
None
None
None
None
 1.10A 2gssB-4uqmA:
undetectable		 2gssB-4uqmA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		3 / 3 PHE A  96
SER A 204
LEU A 182
 None
 0.67A 2w1bA-4uqmA:
undetectable		 2w1bA-4uqmA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 11 PHE A 163
PHE A  40
SER A  36
PHE A  64
LEU A 141
 None
 1.10A 3a9eB-4uqmA:
undetectable		 3a9eB-4uqmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 9 TYR A  85
VAL A  98
ILE A 111
TYR A 112
GLY A 128
 CL  A1245 (-4.3A)
None
None
None
None
 1.19A 3csjB-4uqmA:
undetectable		 3csjB-4uqmA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		4 / 6 HIS A 155
LEU A  47
ALA A  60
PRO A  58
 None
 0.94A 3gv1A-4uqmA:
undetectable
3gv1C-4uqmA:
undetectable		 3gv1A-4uqmA:
17.67
3gv1C-4uqmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		4 / 6 LEU A  47
ALA A  60
PRO A  58
HIS A 155
 None
 0.89A 3gv1A-4uqmA:
undetectable
3gv1B-4uqmA:
undetectable		 3gv1A-4uqmA:
17.67
3gv1B-4uqmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		3 / 3 ILE A  79
PHE A 221
HIS A 206
 None
 0.68A 3h0aA-4uqmA:
undetectable		 3h0aA-4uqmA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		3 / 3 ILE A 181
PHE A 221
HIS A 206
 None
 0.59A 3h0aA-4uqmA:
undetectable		 3h0aA-4uqmA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 11 ASN A  65
LEU A  23
ALA A 166
LEU A  43
PHE A  35
 None
 1.31A 3jwqB-4uqmA:
undetectable
3jwqC-4uqmA:
undetectable		 3jwqB-4uqmA:
22.85
3jwqC-4uqmA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 8 TYR A  85
VAL A  98
ILE A 111
TYR A 112
GLY A 128
 CL  A1245 (-4.3A)
None
None
None
None
 1.17A 3n9jA-4uqmA:
undetectable		 3n9jA-4uqmA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		4 / 8 PHE A  35
ALA A  37
PHE A  64
PHE A 163
 None
 0.95A 3t3sF-4uqmA:
undetectable		 3t3sF-4uqmA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		8 / 8 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
SER A 107
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
None
CL  A1245 (-4.0A)
None
 0.33A 4wryA-4uqmA:
34.1		 4wryA-4uqmA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		8 / 8 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
SER A 107
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
None
CL  A1245 (-4.0A)
None
 0.28A 4wrzA-4uqmA:
34.3		 4wrzA-4uqmA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		7 / 7 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
CL  A1245 (-4.0A)
None
 0.75A 4ws0A-4uqmA:
33.4		 4ws0A-4uqmA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		8 / 8 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
SER A 107
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
None
CL  A1245 (-4.0A)
None
 0.71A 4ws1A-4uqmA:
33.6		 4ws1A-4uqmA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  43
LEU A  67
LEU A  23
PHE A  40
ALA A 166
 None
 1.16A 5ieoA-4uqmA:
undetectable		 5ieoA-4uqmA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  43
LEU A  67
LEU A  23
PHE A  40
THR A 164
 None
 1.35A 5ieoA-4uqmA:
undetectable		 5ieoA-4uqmA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  43
LEU A  67
LEU A  23
PHE A  40
ALA A 166
 None
 1.17A 5iepA-4uqmA:
undetectable		 5iepA-4uqmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 10 ILE A 111
LEU A  94
VAL A 138
LEU A 139
SER A  95
 None
 1.29A 5tixB-4uqmA:
undetectable		 5tixB-4uqmA:
21.16