SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4uqw PROTEIN CLPV1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  45
LEU A 131
SER A  60
ILE A  62
LEU A  67
 None
 1.14A 1ddsB-4uqwA:
undetectable		 1ddsB-4uqwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4uqw PROTEIN CLPV1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  45
LEU A 131
SER A  60
ILE A  62
LEU A  67
 None
 1.24A 1rh3A-4uqwA:
undetectable		 1rh3A-4uqwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4uqw PROTEIN CLPV1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  45
LEU A 131
SER A  60
ILE A  62
LEU A  67
 None
 1.13A 1rx3A-4uqwA:
undetectable		 1rx3A-4uqwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4uqw PROTEIN CLPV1
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  53
ALA A  68
LEU A  67
GLN A  44
 None
 0.93A 3cldB-4uqwA:
undetectable		 3cldB-4uqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4uqw PROTEIN CLPV1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  45
LEU A 131
SER A  60
ILE A  62
LEU A  67
 None
 1.16A 4gh8A-4uqwA:
undetectable		 4gh8A-4uqwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4uqw PROTEIN CLPV1
(Pseudomonas
aeruginosa) 		5 / 12 SER A  60
SER A  51
LEU A 122
PHE A  42
LEU A 131
 None
 1.18A 6a93A-4uqwA:
undetectable		 6a93A-4uqwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4uqw PROTEIN CLPV1
(Pseudomonas
aeruginosa) 		5 / 12 SER A  60
SER A  51
LEU A 122
PHE A  42
LEU A 131
 None
 1.19A 6a93B-4uqwA:
undetectable		 6a93B-4uqwA:
18.68