SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4uqz HSIB1
HSIE1
(Pseudomonas
aeruginosa) 		4 / 8 TYR B  28
SER A  53
GLU A  49
LEU A  47
 None
 0.89A 1eupA-4uqzB:
undetectable		 1eupA-4uqzB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 150
GLY A 143
ASP A 138
 None
ACT  A 301 (-4.2A)
None
 0.58A 1kf6A-4uqzA:
2.8
1kf6B-4uqzA:
undetectable		 1kf6A-4uqzA:
19.64
1kf6B-4uqzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4uqz HSIE1
HSIB1
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		3 / 3 ARG B  15
GLU A 273
ASP A 278
 None
 0.83A 3g2oA-4uqzB:
undetectable		 3g2oA-4uqzB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 6 ARG A  52
LEU A  60
PRO A  55
SER A  53
 None
 1.40A 3vlnA-4uqzA:
undetectable		 3vlnA-4uqzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 241
GLU A 238
ARG A 235
GLY A  72
 None
 0.96A 4fgzA-4uqzA:
undetectable
4fgzB-4uqzA:
undetectable		 4fgzA-4uqzA:
17.75
4fgzB-4uqzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 128
LEU A 199
ASP A 174
LEU A 179
GLY A 180
 None
 1.27A 4fogD-4uqzA:
undetectable		 4fogD-4uqzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4uqz HSIE1
HSIB1
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		4 / 5 LYS A  30
LEU A  35
GLU A  32
LEU B  27
 None
 1.23A 4k4yA-4uqzA:
undetectable		 4k4yA-4uqzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4uqz HSIE1
HSIB1
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		4 / 4 LYS A  30
LEU A  35
GLU A  32
LEU B  27
 None
 1.27A 4k4yE-4uqzA:
undetectable		 4k4yE-4uqzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4uqz HSIE1
HSIB1
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		4 / 5 LYS A  30
LEU A  35
GLU A  32
LEU B  27
 None
 1.21A 4k4yI-4uqzA:
undetectable		 4k4yI-4uqzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 238
THR A 239
GLU A 254
LEU A 266
 None
 1.06A 5hm8A-4uqzA:
undetectable		 5hm8A-4uqzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 238
THR A 239
GLU A 254
LEU A 266
 None
 1.07A 5hm8B-4uqzA:
undetectable		 5hm8B-4uqzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 238
THR A 239
GLU A 254
LEU A 266
 None
 1.06A 5hm8C-4uqzA:
undetectable		 5hm8C-4uqzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 238
THR A 239
GLU A 254
LEU A 266
 None
 1.06A 5hm8D-4uqzA:
undetectable		 5hm8D-4uqzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 238
THR A 239
GLU A 254
LEU A 266
 None
 1.07A 5hm8E-4uqzA:
undetectable		 5hm8E-4uqzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 238
THR A 239
GLU A 254
LEU A 266
 None
 1.06A 5hm8F-4uqzA:
undetectable		 5hm8F-4uqzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 238
THR A 239
GLU A 254
LEU A 266
 None
 1.07A 5hm8H-4uqzA:
undetectable		 5hm8H-4uqzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4uqz HSIE1
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 238
PRO A 261
ARG A 178
ARG A 265
 None
 1.42A 5jcnB-4uqzA:
undetectable		 5jcnB-4uqzA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4uqz HSIB1
HSIE1
(Pseudomonas
aeruginosa) 		4 / 8 ASN A  57
ASP A  88
VAL A  84
GLY B  29
 None
 0.65A 5kr1B-4uqzA:
undetectable		 5kr1B-4uqzA:
15.62