SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ur8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 6 LEU A 292
ILE A 240
ARG A 239
VAL A 218
 None
 1.05A 1db1A-4ur8A:
undetectable		 1db1A-4ur8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.14A 1jffB-4ur8A:
undetectable		 1jffB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 11 LEU A  60
GLU A  64
ALA A  70
ARG A 278
PHE A  22
 None
 1.35A 1l5rA-4ur8A:
undetectable		 1l5rA-4ur8A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 11 LEU A  60
GLU A  64
ALA A  71
ARG A 278
PHE A  22
 None
 1.42A 1l5rA-4ur8A:
undetectable		 1l5rA-4ur8A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 154
TYR A 123
LYS A 127
 None
 0.66A 1uujB-4ur8A:
undetectable		 1uujB-4ur8A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 GLY A  55
GLY A  53
SER A 212
LEU A  48
LEU A 189
 None
OOG  A1305 (-3.1A)
None
None
None
 0.99A 1ya4C-4ur8A:
undetectable		 1ya4C-4ur8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 8 ILE A  68
ARG A 278
LEU A  60
GLU A  64
 None
 0.89A 2cdqA-4ur8A:
undetectable		 2cdqA-4ur8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 11 THR A  67
ALA A  70
GLY A  84
ALA A  50
SER A  98
 None
 1.09A 2f162-4ur8A:
undetectable		 2f162-4ur8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 11 THR A  67
ALA A  70
GLY A  84
ALA A  50
SER A  98
 None
 1.09A 2f16N-4ur8A:
undetectable		 2f16N-4ur8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 ALA A  50
GLY A  84
LEU A  60
LEU A 108
PRO A  18
 None
 1.04A 2f8lA-4ur8A:
undetectable		 2f8lA-4ur8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.13A 2hxfB-4ur8A:
undetectable		 2hxfB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.13A 2hxhB-4ur8A:
undetectable		 2hxhB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.13A 2p4nB-4ur8A:
undetectable		 2p4nB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 6 GLY A 190
GLY A 164
PHE A  49
PHE A  17
 None
None
None
OOG  A1305 (-4.0A)
 1.00A 2qx6A-4ur8A:
undetectable
2qx6B-4ur8A:
undetectable		 2qx6A-4ur8A:
22.15
2qx6B-4ur8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 6 TYR A 202
ASP A 167
PHE A 207
ASP A 171
 None
 1.34A 2todA-4ur8A:
8.3
2todB-4ur8A:
8.2		 2todA-4ur8A:
22.14
2todB-4ur8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.13A 2wbeB-4ur8A:
undetectable		 2wbeB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.13A 3dcoB-4ur8A:
undetectable		 3dcoB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.14A 3edlB-4ur8A:
undetectable		 3edlB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.14A 3iz0B-4ur8A:
undetectable		 3iz0B-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 THR A  67
ALA A  70
GLY A  84
ALA A  50
SER A  98
 None
 1.08A 3mg02-4ur8A:
undetectable
3mg0V-4ur8A:
undetectable		 3mg02-4ur8A:
22.00
3mg0V-4ur8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 11 THR A  67
ALA A  70
GLY A  84
ALA A  50
SER A  98
 None
 1.06A 3mg0N-4ur8A:
undetectable		 3mg0N-4ur8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		3 / 3 LYS A 302
ARG A 301
TRP A  39
 None
 1.01A 4i90A-4ur8A:
1.3		 4i90A-4ur8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 ALA A 195
PRO A 193
GLY A 191
GLY A 168
LEU A  15
 None
OOG  A1305 ( 4.7A)
OOG  A1305 (-4.5A)
None
None
 1.05A 5c0oH-4ur8A:
undetectable		 5c0oH-4ur8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 5 PRO A 111
LEU A  15
TYR A 202
PHE A 198
 None
 1.37A 5igjA-4ur8A:
undetectable		 5igjA-4ur8A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 7 GLU A 196
ALA A 195
PHE A 248
ASN A 216
 None
 0.76A 5mvsA-4ur8A:
undetectable		 5mvsA-4ur8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 8 GLU A 196
ALA A 195
PHE A 248
ASN A 216
 None
 0.78A 5mvsB-4ur8A:
undetectable		 5mvsB-4ur8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.14A 5ogcB-4ur8A:
undetectable		 5ogcB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		5 / 10 LEU A  15
SER A 211
PHE A  49
GLY A 164
GLY A 168
 None
OOG  A1305 ( 3.8A)
None
None
None
 1.18A 6eu9B-4ur8A:
undetectable		 6eu9B-4ur8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE
(Agrobacterium
tumefaciens) 		4 / 7 VAL A  99
GLY A 106
LEU A 109
GLY A  86
 None
 0.75A 6eu9D-4ur8A:
undetectable		 6eu9D-4ur8A:
16.49