SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4url'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 9 ASN A  49
ASP A  76
ARG A 138
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.6A)
None
None
XAM  A2000 (-3.6A)
 1.45A 1aj6A-4urlA:
29.6		 1aj6A-4urlA:
42.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		7 / 9 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.71A 1aj6A-4urlA:
29.6		 1aj6A-4urlA:
42.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		7 / 12 ASP A  52
GLU A  53
ASP A  76
ARG A  79
ILE A  96
ARG A 138
THR A 168
 None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
None
None
XAM  A2000 (-3.6A)
 0.76A 1kijA-4urlA:
44.0		 1kijA-4urlA:
46.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		7 / 12 ASP A  52
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
THR A 168
 None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.71A 1kijA-4urlA:
44.0		 1kijA-4urlA:
46.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		7 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
ALA A 122
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 ( 4.3A)
None
XAM  A2000 (-3.6A)
 0.71A 1kijB-4urlA:
44.2		 1kijB-4urlA:
46.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		8 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ALA A 122
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
XAM  A2000 ( 4.3A)
XAM  A2000 (-3.6A)
 0.79A 1kijB-4urlA:
44.2		 1kijB-4urlA:
46.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 12 GLY A 322
ASN A 235
PHE A 297
LEU A 377
PHE A 247
 None
 1.41A 1pj7A-4urlA:
1.5		 1pj7A-4urlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 12 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
ILE A  96
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
None
None
XAM  A2000 (-3.6A)
 0.63A 1s14A-4urlA:
24.7		 1s14A-4urlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 12 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.56A 1s14A-4urlA:
24.7		 1s14A-4urlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		8 / 12 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
ARG A 138
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
None
 0.67A 1s14B-4urlA:
26.9		 1s14B-4urlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		9 / 12 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
XAM  A2000 (-4.8A)
None
 0.56A 1s14B-4urlA:
26.9		 1s14B-4urlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 8 TYR A 262
ASN A 263
LYS A 238
GLU A 321
GLY A 322
 None
 1.37A 1ykiA-4urlA:
undetectable
1ykiB-4urlA:
undetectable		 1ykiA-4urlA:
21.25
1ykiB-4urlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 8 TYR A 262
ASN A 263
LYS A 238
GLU A 321
GLY A 322
 None
 1.36A 1ykiA-4urlA:
undetectable
1ykiB-4urlA:
undetectable		 1ykiA-4urlA:
21.25
1ykiB-4urlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 8 TYR A 262
ASN A 263
LYS A 238
GLU A 321
GLY A 322
 None
 1.38A 1ykiC-4urlA:
undetectable
1ykiD-4urlA:
undetectable		 1ykiC-4urlA:
21.25
1ykiD-4urlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 8 TYR A 262
ASN A 263
LYS A 238
GLU A 321
GLY A 322
 None
 1.33A 1ykiC-4urlA:
undetectable
1ykiD-4urlA:
undetectable		 1ykiC-4urlA:
21.25
1ykiD-4urlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 11 LEU A 346
LEU A 336
ILE A 227
VAL A 256
ILE A 254
 None
 1.09A 2uxoB-4urlA:
undetectable		 2uxoB-4urlA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		4 / 7 ASP A  35
SER A  33
GLU A  45
ASP A  48
 None
 1.27A 3bc9A-4urlA:
undetectable		 3bc9A-4urlA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		3 / 3 TYR A 233
GLU A 219
ASP A 210
 None
 0.88A 3bxoB-4urlA:
undetectable		 3bxoB-4urlA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		4 / 6 ALA A 259
SER A 248
THR A 246
VAL A 244
 None
 0.91A 3d2tB-4urlA:
undetectable		 3d2tB-4urlA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		4 / 4 LEU A  42
ALA A 127
VAL A  23
PRO A  27
 None
 1.08A 3gv1B-4urlA:
undetectable		 3gv1B-4urlA:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 12 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
ILE A  96
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
None
None
XAM  A2000 (-3.6A)
 0.67A 3lpsA-4urlA:
39.8		 3lpsA-4urlA:
35.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 12 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.53A 3lpsA-4urlA:
39.8		 3lpsA-4urlA:
35.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 12 PHE A 247
GLY A 371
LYS A 370
LEU A 377
PHE A 297
 None
 1.28A 4kykA-4urlA:
undetectable
4kykB-4urlA:
undetectable		 4kykA-4urlA:
17.16
4kykB-4urlA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		4 / 4 ALA A 387
ALA A 390
ALA A 391
ALA A 394
 None
 0.11A 4oadA-4urlA:
undetectable		 4oadA-4urlA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		4 / 4 ALA A 387
ALA A 390
ALA A 391
ALA A 394
 None
 0.13A 4oaeA-4urlA:
undetectable		 4oaeA-4urlA:
15.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 11 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.76A 4urnA-4urlA:
32.8		 4urnA-4urlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 11 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
MET A  81
PRO A  82
ILE A  96
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-4.3A)
XAM  A2000 (-4.8A)
None
None
XAM  A2000 (-3.6A)
 0.79A 4urnA-4urlA:
32.8		 4urnA-4urlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 11 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.64A 4urnB-4urlA:
29.3		 4urnB-4urlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		9 / 11 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
MET A  81
ILE A  96
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-4.3A)
None
None
XAM  A2000 (-3.6A)
 0.76A 4urnB-4urlA:
29.3		 4urnB-4urlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		10 / 11 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.3A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.62A 4urnC-4urlA:
32.4		 4urnC-4urlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		8 / 11 ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
MET A  81
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
None
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-4.3A)
None
XAM  A2000 (-3.6A)
 0.70A 4urnC-4urlA:
32.4		 4urnC-4urlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		7 / 12 ASN A  49
SER A  50
GLU A  53
ASP A  76
ARG A  79
ILE A  96
ARG A 138
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
None
None
 0.68A 4uroA-4urlA:
29.8		 4uroA-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		7 / 12 ASN A  49
SER A  50
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
 0.61A 4uroA-4urlA:
29.8		 4uroA-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		6 / 12 ASN A  49
SER A  50
GLU A  53
ASP A  76
ARG A  79
ARG A 138
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
None
 0.66A 4uroB-4urlA:
29.8		 4uroB-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		7 / 12 ASN A  49
SER A  50
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
 0.63A 4uroB-4urlA:
29.8		 4uroB-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		5 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
ARG A 138
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
None
 0.72A 4uroC-4urlA:
30.0		 4uroC-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		6 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
 0.58A 4uroC-4urlA:
30.0		 4uroC-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		8 / 12 ASN A  49
SER A  50
GLU A  53
ASP A  76
ARG A  79
ILE A  96
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
None
None
XAM  A2000 (-3.6A)
 0.74A 4uroD-4urlA:
29.6		 4uroD-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		8 / 12 ASN A  49
SER A  50
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
XAM  A2000 (-3.6A)
 0.64A 4uroD-4urlA:
29.6		 4uroD-4urlA:
37.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		3 / 3 LYS A 118
HIS A  41
HIS A 118
 None
 1.39A 5oexA-4urlA:
undetectable		 5oexA-4urlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		3 / 3 LYS A 118
HIS A  41
HIS A 118
 None
 1.36A 5oexB-4urlA:
undetectable		 5oexB-4urlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		3 / 3 LYS A 118
HIS A  41
HIS A 118
 None
 1.35A 5oexC-4urlA:
undetectable		 5oexC-4urlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4url DNA TOPOISOMERASE
IV, B SUBUNIT
(Staphylococcus
aureus) 		3 / 3 LYS A 118
HIS A  41
HIS A 118
 None
 1.37A 5oexD-4urlA:
undetectable		 5oexD-4urlA:
20.55