SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4urs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_FFOA1293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	3 / 3	GLU A 170 TYR A 166 PHE A 124	GLU A 170 ( 0.6A) TYR A 166 ( 1.3A) PHE A 124 ( 1.3A)	0.92A	1eqbB-4ursA: undetectable	1eqbB-4ursA: 16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_FFOB2293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	3 / 3	GLU A 170 TYR A 166 PHE A 124	GLU A 170 ( 0.6A) TYR A 166 ( 1.3A) PHE A 124 ( 1.3A)	0.92A	1eqbA-4ursA: undetectable	1eqbA-4ursA: 16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_FFOC3293_2 (SERINE HYDROXYMETHYLTRANSFE RASE)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	3 / 3	GLU A 170 TYR A 166 PHE A 124	GLU A 170 ( 0.6A) TYR A 166 ( 1.3A) PHE A 124 ( 1.3A)	0.92A	1eqbD-4ursA: undetectable	1eqbD-4ursA: 16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_FFOD4293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	3 / 3	GLU A 170 TYR A 166 PHE A 124	GLU A 170 ( 0.6A) TYR A 166 ( 1.3A) PHE A 124 ( 1.3A)	0.93A	1eqbC-4ursA: undetectable	1eqbC-4ursA: 16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LIK_A_ADNA699_1 (ADENOSINE KINASE)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	5 / 12	ASP A 143 LEU A 96 GLY A 142 ASN A 134 THR A 94	ASP A 143 ( 0.6A) LEU A 96 ( 0.6A) GLY A 142 ( 0.0A) ASN A 134 ( 0.6A) THR A 94 ( 0.8A)	1.15A	1likA-4ursA: undetectable	1likA-4ursA: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	5 / 12	GLY A 167 ALA A 128 GLY A 129 ASN A 210 MET A 234	GLY A 167 ( 0.0A) ALA A 128 ( 0.0A) GLY A 129 ( 0.0A) ASN A 210 ( 0.6A) MET A 234 ( 0.0A)	1.23A	3v3oA-4ursA: undetectable	3v3oA-4ursA: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IFX_A_ACTA404_0 (THIAMINE BIOSYNTHESIS LIPOPROTEIN APBE)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	4 / 5	SER A 150 LYS A 147 ARG A 165 LEU A 96	SER A 150 ( 0.0A) LYS A 147 ( 0.0A) ARG A 165 ( 0.6A) LEU A 96 ( 0.6A)	1.31A	4ifxA-4ursA: 1.2	4ifxA-4ursA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IG1_A_ACTA504_0 (FAD:PROTEIN FMN TRANSFERASE)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	4 / 5	SER A 150 LYS A 147 ARG A 165 LEU A 96	SER A 150 ( 0.0A) LYS A 147 ( 0.0A) ARG A 165 ( 0.6A) LEU A 96 ( 0.6A)	1.29A	4ig1A-4ursA: undetectable	4ig1A-4ursA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NC3_A_ERMA1202_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	4urs	DIGUANYLATE CYCLASE (Thermotoga maritima)	5 / 12	LEU A 175 VAL A 122 VAL A 157 LEU A 96 VAL A 125	LEU A 175 (-0.5A) VAL A 122 ( 0.6A) VAL A 157 (-0.6A) LEU A 96 ( 0.6A) VAL A 125 ( 0.5A)	1.33A	4nc3A-4ursA: undetectable	4nc3A-4ursA: 18.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EQB_A_FFOA1293_1","SERINE HYDROXYMETHYLTRANSFERASE","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",3,"GLU A 170;TYR A 166;PHE A 124","GLU A 170 ( 0.6A);TYR A 166 ( 1.3A);PHE A 124 ( 1.3A)","0.92A","1eqbB-4ursA:undetectable","1eqbB-4ursA:16.71"],["1EQB_B_FFOB2293_0","SERINE HYDROXYMETHYLTRANSFERASE","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",3,"GLU A 170;TYR A 166;PHE A 124","GLU A 170 ( 0.6A);TYR A 166 ( 1.3A);PHE A 124 ( 1.3A)","0.92A","1eqbA-4ursA:undetectable","1eqbA-4ursA:16.71"],["1EQB_C_FFOC3293_2","SERINE HYDROXYMETHYLTRANSFERASE","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",3,"GLU A 170;TYR A 166;PHE A 124","GLU A 170 ( 0.6A);TYR A 166 ( 1.3A);PHE A 124 ( 1.3A)","0.92A","1eqbD-4ursA:undetectable","1eqbD-4ursA:16.71"],["1EQB_D_FFOD4293_0","SERINE HYDROXYMETHYLTRANSFERASE","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",3,"GLU A 170;TYR A 166;PHE A 124","GLU A 170 ( 0.6A);TYR A 166 ( 1.3A);PHE A 124 ( 1.3A)","0.93A","1eqbC-4ursA:undetectable","1eqbC-4ursA:16.71"],["1LIK_A_ADNA699_1","ADENOSINE KINASE","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",5,"ASP A 143;LEU A  96;GLY A 142;ASN A 134;THR A  94","ASP A 143 ( 0.6A);LEU A  96 ( 0.6A);GLY A 142 ( 0.0A);ASN A 134 ( 0.6A);THR A  94 ( 0.8A)","1.15A","1likA-4ursA:undetectable","1likA-4ursA:20.73"],["3V3O_A_T1CA404_1","TETX2 PROTEIN","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",5,"GLY A 167;ALA A 128;GLY A 129;ASN A 210;MET A 234","GLY A 167 ( 0.0A);ALA A 128 ( 0.0A);GLY A 129 ( 0.0A);ASN A 210 ( 0.6A);MET A 234 ( 0.0A)","1.23A","3v3oA-4ursA:undetectable","3v3oA-4ursA:19.58"],["4IFX_A_ACTA404_0","THIAMINE BIOSYNTHESIS LIPOPROTEIN APBE","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",4,"SER A 150;LYS A 147;ARG A 165;LEU A  96","SER A 150 ( 0.0A);LYS A 147 ( 0.0A);ARG A 165 ( 0.6A);LEU A  96 ( 0.6A)","1.31A","4ifxA-4ursA:1.2","4ifxA-4ursA:19.77"],["4IG1_A_ACTA504_0","FAD:PROTEIN FMN TRANSFERASE","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",4,"SER A 150;LYS A 147;ARG A 165;LEU A  96","SER A 150 ( 0.0A);LYS A 147 ( 0.0A);ARG A 165 ( 0.6A);LEU A  96 ( 0.6A)","1.29A","4ig1A-4ursA:undetectable","4ig1A-4ursA:19.77"],["4NC3_A_ERMA1202_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562","4urs","DIGUANYLATE CYCLASE","Thermotoga maritima",5,"LEU A 175;VAL A 122;VAL A 157;LEU A  96;VAL A 125","LEU A 175 (-0.5A);VAL A 122 ( 0.6A);VAL A 157 (-0.6A);LEU A  96 ( 0.6A);VAL A 125 ( 0.5A)","1.33A","4nc3A-4ursA:undetectable","4nc3A-4ursA:18.93"]]