SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4us5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.96A 1v55C-4us5A:
1.1
1v55J-4us5A:
undetectable		 1v55C-4us5A:
20.29
1v55J-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 ALA A 187
GLY A  74
GLY A  75
SER A 173
LEU A 137
 None
 0.87A 1ya4A-4us5A:
undetectable		 1ya4A-4us5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 4 LEU A 180
PRO A 162
ILE A 105
LEU A 166
 None
 1.03A 1ya4B-4us5A:
undetectable		 1ya4B-4us5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 10 LEU A 133
ARG A 107
LEU A 164
THR A 212
PHE A 206
 NA  A1337 ( 4.7A)
None
None
None
None
 1.20A 1zucA-4us5A:
undetectable		 1zucA-4us5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 LEU A 133
ARG A 107
LEU A 164
THR A 212
PHE A 206
 NA  A1337 ( 4.7A)
None
None
None
None
 1.22A 1zucB-4us5A:
undetectable		 1zucB-4us5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 GLY A  35
SER A   4
ARG A 334
GLU A 305
 None
 0.91A 2c8aB-4us5A:
undetectable		 2c8aB-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 GLY A  35
SER A   4
ARG A 334
GLU A 305
 None
 1.09A 2c8aD-4us5A:
undetectable		 2c8aD-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.97A 2dysP-4us5A:
undetectable
2dysW-4us5A:
undetectable		 2dysP-4us5A:
20.29
2dysW-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.98A 2eijC-4us5A:
undetectable
2eijJ-4us5A:
undetectable		 2eijC-4us5A:
20.29
2eijJ-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.95A 2eikC-4us5A:
undetectable
2eikJ-4us5A:
undetectable		 2eikC-4us5A:
20.29
2eikJ-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.92A 2eimC-4us5A:
undetectable
2eimJ-4us5A:
undetectable		 2eimC-4us5A:
20.29
2eimJ-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.97A 2einC-4us5A:
undetectable
2einJ-4us5A:
undetectable		 2einC-4us5A:
20.29
2einJ-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 6 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.99A 2einP-4us5A:
undetectable
2einW-4us5A:
undetectable		 2einP-4us5A:
20.29
2einW-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		3 / 3 ARG A 323
ASP A 314
ASP A 258
 None
 0.84A 2ejtA-4us5A:
undetectable		 2ejtA-4us5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		3 / 3 ASP A 250
ARG A 244
ARG A 245
 None
 1.10A 2j9dA-4us5A:
undetectable
2j9dC-4us5A:
undetectable		 2j9dA-4us5A:
16.18
2j9dC-4us5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 LEU A  78
LEU A 167
LEU A 166
LEU A 164
GLY A  74
 None
 0.96A 2ouzA-4us5A:
undetectable		 2ouzA-4us5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 6 THR A 238
LEU A 254
VAL A 222
VAL A 309
 None
None
None
NA  A1340 (-3.7A)
 0.90A 2z97A-4us5A:
undetectable		 2z97A-4us5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.98A 3ag2P-4us5A:
undetectable
3ag2W-4us5A:
undetectable		 3ag2P-4us5A:
20.29
3ag2W-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.92A 3ag4P-4us5A:
undetectable
3ag4W-4us5A:
undetectable		 3ag4P-4us5A:
20.29
3ag4W-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.93A 3ln1A-4us5A:
undetectable		 3ln1A-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.93A 3ln1B-4us5A:
undetectable		 3ln1B-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.93A 3ln1C-4us5A:
undetectable		 3ln1C-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.93A 3ln1D-4us5A:
undetectable		 3ln1D-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 GLY A  72
GLY A  74
LEU A 167
GLU A  43
LEU A  93
 None
None
None
NA  A1338 (-3.2A)
None
 1.11A 3vywA-4us5A:
undetectable		 3vywA-4us5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		3 / 3 ARG A 196
ARG A 203
ASP A 299
 None
 0.95A 3wipG-4us5A:
undetectable
3wipH-4us5A:
undetectable		 3wipG-4us5A:
21.26
3wipH-4us5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.92A 3x2qC-4us5A:
undetectable
3x2qJ-4us5A:
undetectable		 3x2qC-4us5A:
20.29
3x2qJ-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 LEU A 140
GLN A 139
LEU A 103
PHE A  90
 None
 0.91A 3x2qP-4us5A:
undetectable
3x2qW-4us5A:
undetectable		 3x2qP-4us5A:
20.29
3x2qW-4us5A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
SER A 220
LEU A 167
ASN A  50
GLN A   8
 NA  A1340 (-3.7A)
None
None
None
NA  A1340 (-3.2A)
 0.97A 4kuoA-4us5A:
undetectable		 4kuoA-4us5A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 6 LEU A 219
PRO A 280
PHE A 277
GLU A 275
 None
 1.20A 5b8iA-4us5A:
undetectable		 5b8iA-4us5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 6 LEU A 331
SER A   4
PHE A  39
GLU A   7
 None
None
None
NA  A1335 (-3.2A)
 1.23A 5b8iA-4us5A:
undetectable		 5b8iA-4us5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.90A 5jw1A-4us5A:
undetectable		 5jw1A-4us5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.94A 5kirA-4us5A:
0.0		 5kirA-4us5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.94A 5kirB-4us5A:
undetectable		 5kirB-4us5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 ILE A 105
LEU A 164
VAL A  76
GLY A  75
GLY A  72
 None
None
NA  A1338 ( 4.4A)
None
None
 1.23A 5nnaD-4us5A:
undetectable		 5nnaD-4us5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		4 / 7 ARG A  38
PHE A  39
ARG A 334
ASP A  32
 EPE  A1341 (-3.0A)
None
None
None
 1.25A 5uxcA-4us5A:
undetectable		 5uxcA-4us5A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4us5 LUCIFERASE-LIKE
MONOOXYGENASE
(Streptomyces
bottropensis) 		5 / 12 HIS A 239
ILE A  48
MET A 246
HIS A 243
TYR A 282
 None
 1.23A 6md4A-4us5A:
undetectable		 6md4A-4us5A:
12.00