SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4usr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 VAL A 265
GLY A 264
LEU A 275
VAL A 170
PHE A 257
 None
 1.31A 1a27A-4usrA:
4.9		 1a27A-4usrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		3 / 3 ALA A 181
VAL A 179
TRP A  47
 None
 0.86A 1av2C-4usrA:
undetectable
1av2D-4usrA:
undetectable		 1av2C-4usrA:
4.39
1av2D-4usrA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 11 GLN A  14
GLY A 130
GLY A 320
ASP A  34
THR A 131
 FAD  A1355 (-3.0A)
FAD  A1355 (-3.3A)
FAD  A1355 (-4.4A)
FAD  A1355 (-2.9A)
None
 1.11A 1jg3A-4usrA:
2.1		 1jg3A-4usrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 11 GLN A  14
GLY A 130
GLY A 320
ASP A  34
THR A 131
 FAD  A1355 (-3.0A)
FAD  A1355 (-3.3A)
FAD  A1355 (-4.4A)
FAD  A1355 (-2.9A)
None
 1.12A 1jg3B-4usrA:
2.8		 1jg3B-4usrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		3 / 3 ALA A 177
VAL A 179
TRP A  47
 None
 0.64A 1nt6A-4usrA:
undetectable		 1nt6A-4usrA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		3 / 3 ALA A 177
VAL A 179
TRP A  47
 None
 0.64A 1nt6B-4usrA:
undetectable		 1nt6B-4usrA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		3 / 3 ALA A 181
VAL A 179
TRP A  47
 None
 0.84A 1w5uC-4usrA:
undetectable
1w5uD-4usrA:
undetectable		 1w5uC-4usrA:
4.39
1w5uD-4usrA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 5 ILE A 137
PRO A 138
PHE A 257
VAL A 170
 None
GOL  A1356 ( 4.9A)
None
None
 1.29A 2hjhB-4usrA:
undetectable		 2hjhB-4usrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 5 ILE A 137
PRO A 138
PHE A 260
VAL A 170
 None
GOL  A1356 ( 4.9A)
None
None
 1.27A 2hjhB-4usrA:
undetectable		 2hjhB-4usrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 TYR A 321
SER A 133
ALA A 287
GLY A  41
TRP A  43
 None
FAD  A1355 ( 4.2A)
FAD  A1355 ( 4.6A)
FAD  A1355 (-3.4A)
FAD  A1355 (-4.0A)
 1.02A 2igtA-4usrA:
undetectable		 2igtA-4usrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 TYR A 321
SER A 133
ALA A 287
GLY A  41
TRP A  43
 None
FAD  A1355 ( 4.2A)
FAD  A1355 ( 4.6A)
FAD  A1355 (-3.4A)
FAD  A1355 (-4.0A)
 1.02A 2igtB-4usrA:
3.2		 2igtB-4usrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		3 / 3 ALA A 177
VAL A 179
TRP A  47
 None
 0.84A 3l8lA-4usrA:
undetectable
3l8lB-4usrA:
undetectable		 3l8lA-4usrA:
4.39
3l8lB-4usrA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 6 GLU A 144
TRP A 280
ARG A 143
GLY A 142
 None
 1.43A 3oxvA-4usrA:
undetectable		 3oxvA-4usrA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 ILE A 126
GLY A  63
PHE A  93
ILE A 333
THR A 336
 None
 1.10A 3pwwA-4usrA:
undetectable		 3pwwA-4usrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 11 THR A 338
ALA A 339
PHE A  22
PHE A 210
ILE A 333
 None
 1.33A 4claA-4usrA:
undetectable		 4claA-4usrA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 11 THR A 338
THR A  18
THR A  19
SER A 329
THR A 331
 None
None
None
None
FAD  A1355 (-4.0A)
 1.46A 4qvyV-4usrA:
undetectable
4qvyb-4usrA:
undetectable		 4qvyV-4usrA:
23.31
4qvyb-4usrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 11 THR A 338
THR A  18
THR A  19
SER A 329
THR A 331
 None
None
None
None
FAD  A1355 (-4.0A)
 1.46A 4qvyH-4usrA:
undetectable
4qvyN-4usrA:
undetectable		 4qvyH-4usrA:
23.31
4qvyN-4usrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 5 ILE A 279
VAL A 179
VAL A 169
THR A 189
 None
 0.75A 4xdtA-4usrA:
undetectable		 4xdtA-4usrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 GLY A  12
GLY A 320
GLY A 130
GLY A  11
ASP A 323
 FAD  A1355 (-4.5A)
FAD  A1355 (-4.4A)
FAD  A1355 (-3.3A)
FAD  A1355 (-3.3A)
None
 0.91A 5kqrA-4usrA:
undetectable		 5kqrA-4usrA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 11 THR A 338
THR A  18
THR A  19
SER A 329
THR A 331
 None
None
None
None
FAD  A1355 (-4.0A)
 1.46A 5l5fV-4usrA:
undetectable
5l5fb-4usrA:
undetectable		 5l5fV-4usrA:
23.31
5l5fb-4usrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 11 THR A 338
THR A  18
THR A  19
SER A 329
THR A 331
 None
None
None
None
FAD  A1355 (-4.0A)
 1.45A 5l5fH-4usrA:
undetectable
5l5fN-4usrA:
undetectable		 5l5fH-4usrA:
23.31
5l5fN-4usrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 THR A 338
THR A  18
THR A  19
SER A 329
GLY A 320
 None
None
None
None
FAD  A1355 (-4.4A)
 1.23A 5l5zV-4usrA:
undetectable
5l5zb-4usrA:
undetectable		 5l5zV-4usrA:
23.31
5l5zb-4usrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 THR A 338
THR A  18
THR A  19
SER A 329
GLY A 320
 None
None
None
None
FAD  A1355 (-4.4A)
 1.23A 5l5zH-4usrA:
undetectable
5l5zN-4usrA:
undetectable		 5l5zH-4usrA:
23.31
5l5zN-4usrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 THR A 338
THR A  18
THR A  19
SER A 329
GLY A 320
 None
None
None
None
FAD  A1355 (-4.4A)
 1.20A 5lf3b-4usrA:
undetectable		 5lf3b-4usrA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 THR A 338
THR A  18
THR A  19
SER A 329
GLY A 320
 None
None
None
None
FAD  A1355 (-4.4A)
 1.21A 5lf3N-4usrA:
undetectable		 5lf3N-4usrA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 THR A 338
THR A  18
THR A  19
SER A 329
GLY A 320
 None
None
None
None
FAD  A1355 (-4.4A)
 1.20A 5lf7H-4usrA:
undetectable
5lf7N-4usrA:
undetectable		 5lf7H-4usrA:
20.99
5lf7N-4usrA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 GLY A  12
GLY A 320
GLY A 130
GLY A  11
ASP A 323
 FAD  A1355 (-4.5A)
FAD  A1355 (-4.4A)
FAD  A1355 (-3.3A)
FAD  A1355 (-3.3A)
None
 0.95A 5m5bA-4usrA:
undetectable		 5m5bA-4usrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 GLY A  12
GLY A 320
GLY A 130
GLY A  11
ASP A 323
 FAD  A1355 (-4.5A)
FAD  A1355 (-4.4A)
FAD  A1355 (-3.3A)
FAD  A1355 (-3.3A)
None
 0.90A 5njvB-4usrA:
undetectable		 5njvB-4usrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 6 GLU A 182
ALA A 181
LEU A 183
TYR A 156
 None
 1.03A 5phhA-4usrA:
undetectable		 5phhA-4usrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		3 / 3 TYR A  91
ALA A  62
TYR A  21
 None
 0.77A 5uunB-4usrA:
undetectable		 5uunB-4usrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		5 / 12 GLY A  12
GLY A 320
GLY A 130
GLY A  11
ASP A 323
 FAD  A1355 (-4.5A)
FAD  A1355 (-4.4A)
FAD  A1355 (-3.3A)
FAD  A1355 (-3.3A)
None
 0.91A 5wz1B-4usrA:
undetectable		 5wz1B-4usrA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 4 GLN A 119
VAL A  99
ARG A 123
ARG A 112
 None
 1.25A 6brdA-4usrA:
12.6		 6brdA-4usrA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 4 ASP A 108
ILE A   4
PRO A   3
LEU A 121
 None
 1.13A 6mkeB-4usrA:
undetectable		 6mkeB-4usrA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4usr MONOOXYGENASE
(Pseudomonas
stutzeri) 		4 / 4 ASP A 108
ILE A   4
PRO A   3
LEU A 121
 None
 1.16A 6mkeA-4usrA:
undetectable		 6mkeA-4usrA:
10.57